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Ameliorating Effect of the Root Extract from Platycodon grandiflorum on the Ethanol-induced Cognitive Impairment in Mice  

Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Kim, Jung-Sook (Korea Research Institute of Chemical Technology)
Choi, Yeon-Hee (Korea Research Institute of Chemical Technology)
Seo, Jee-Hee (Korea Research Institute of Chemical Technology)
Lee, Jung-Won (Korea Research Institute of Chemical Technology)
Kim, Seong-Kie (Korea Research Institute of Chemical Technology)
Kang, Jong-Seong (College of Pharmacy, Chungnam National University)
Lee, Hyun-Sun (Korea Research Institute of Bioscience & Biotechnology)
Cho, Young-Soo (JangSaeng Doraji Research Institute of Biotechnology, JangSaeng Doraji Co. Ltd.)
Roh, Seong-Hwan (JangSaeng Doraji Research Institute of Biotechnology, JangSaeng Doraji Co. Ltd.)
Jeong, Young-Chul (Division of Food Science, Jinju International University)
Shim, Ki-Hwan (Division of Applied Life Science, Gyeongsang National University)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.3, 2004 , pp. 239-243 More about this Journal
Abstract
The ameliorating effect of the MeOH extract of the root of Platycodon grandiflorum on the ethanol-induced cognitive dysfunction in mice was investigated. The total MeOH extract was devided into two fractions, saponin rich fraction and non-saponin fraction. The mice with repeated administration of the total MeOH extract and those with saponin rich fraction both showed a markedly prolongεd latency time upon the step-through test (passive avoidance performance) performed after acute ethanol intoxication, while those with non-saponin rich fraction did not. The results suggest that the extracts from the root of Platycodon grandiflorum exert a beneficial effect on ethanol-induced memory impairment in mice and also suggest that these effects of the extracts might be ascribed to the saponin constituents.
Keywords
Platycodon grandiflorum; cognitive dysfunction; memory; step-through test; passive avoidance performance;
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