Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Screening of Antifungal Natural Products with Inhibitory Effects on (1,3)$\beta$-glucan Synthase

(1,3)$\beta$-Glucansynthase효소 억제 활성을 가진 천연물의 검색

  • Chun Hyun Ja (Department of Chemistry, Wonkwang University) ;
  • Kim Young Sun (Department of Chemistry, Wonkwang University) ;
  • Lee Young Hang (Department of Chemistry, Wonkwang University) ;
  • Kwak Geu Byum (Advanced Materials Chonbuk National University) ;
  • kwon Suk young (Medicinal Resources Research Center of Wonkwang University) ;
  • Kwon Tae Oh (Medicinal Resources Research Center of Wonkwang University) ;
  • Chai Geu Yun (Medicinal Resources Research Center of Wonkwang University)
  • 천현자 (원광대학교 자연과학대학 화학과) ;
  • 김영순 (원광대학교 자연과학대학 화학과) ;
  • 이영행 (원광대학교 자연과학대학 화학과) ;
  • 곽규범 (전북대학교 신소재 공학부) ;
  • 권석용 (원광대학교 의약자원연구센터) ;
  • 권태오 (원광대학교 의약자원연구센터) ;
  • 채규윤 (원광대학교 의약자원연구센터)
  • Published : 2003.12.01
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Abstract

Antifungal activities of the extracts from 26 medicinal plants were investigated utilizing paper-disk diffusion method and (1,3)β-glucan synthase inhibitory assay. (1,3)β-glucan synthase is considered as valuable target in the development of antifungal agents. Among the screened extracts, the ethyl acetate extract of Equisetum arvense, the ethyl acetate extract of Polygonum aviculare, the butanol extract of Crataegus pinnatifida and the n-hexane extract of Saussurea lappa showed significant antifungal activities on Candida albacans in both disk diffusion and enzyme assays.

Keywords

References

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