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Screening of Antifungal Natural Products with Inhibitory Effects on (1,3)$\beta$-glucan Synthase  

Chun Hyun Ja (Department of Chemistry, Wonkwang University)
Kim Young Sun (Department of Chemistry, Wonkwang University)
Lee Young Hang (Department of Chemistry, Wonkwang University)
Kwak Geu Byum (Advanced Materials Chonbuk National University)
kwon Suk young (Medicinal Resources Research Center of Wonkwang University)
Kwon Tae Oh (Medicinal Resources Research Center of Wonkwang University)
Chai Geu Yun (Medicinal Resources Research Center of Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.6, 2003 , pp. 1509-1513 More about this Journal
Abstract
Antifungal activities of the extracts from 26 medicinal plants were investigated utilizing paper-disk diffusion method and (1,3)β-glucan synthase inhibitory assay. (1,3)β-glucan synthase is considered as valuable target in the development of antifungal agents. Among the screened extracts, the ethyl acetate extract of Equisetum arvense, the ethyl acetate extract of Polygonum aviculare, the butanol extract of Crataegus pinnatifida and the n-hexane extract of Saussurea lappa showed significant antifungal activities on Candida albacans in both disk diffusion and enzyme assays.
Keywords
(1 ,3)β-glucan synthase; Candida albacans; Antifungal activity;
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