Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antimicrobial Activities of Sesquiterpene Lactones Isolated from the Flower of Chrysanthemum coronarium L.

쑥갓의 꽃에서 분리한 sesquiterpene lactones의 항균활성

  • Ha, Tae-Jung (Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Han, Hyo-Shim (School of Natural Science, Sunchon National University) ;
  • Jang, Ki-Chang (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Jang, Dae-Sik (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Cho, Dong-Young (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Yang, Min-Suk (Institute of Agriculture and Life Sciences,Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Lee, Kyung-Dong (Institute of Agriculture and Life Science, Gyeongsang National University)
  • 하태정 (경상대학교 농업생명과학원) ;
  • 한효심 (순천대학교 자연과학대학) ;
  • 장기창 (경상대학교 응용생명과학원) ;
  • 장대식 (경상대학교 응용생명과학원) ;
  • 조동령 (경상대학교 응용생명과학원) ;
  • 양민석 (경상대학교 농업생명과학원,응용생명과학원) ;
  • 이경동 (경상대학교 농업생명과학원)
  • Published : 2003.08.30
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Abstract

Thirteen sesquiterpene lactones isolated from the flower of Chrysanthemum coronarium L., which has been widely cultivated in Korea as a vegetable for a long time, were investigated their antimicrobial activities against eight bacteria and five phytopathogenic fungi. The antimicrobial activities of dihydrochrysanolide (6) and 1-epi-dihydrochrysanolide (7) showed strong activities against all the bacteria such as Bacillus subtilis, Bacillus cereus, Staphylococcus aureus and Vibrio parahaemolyticus. Especially, Staphylococcus aureus was investigated that have very strong antibacterial activity to $1.56\;{\mu}g{\cdot}disc^{-1}$, respectively. Also, most of sesquiterpene lactones, which have ${\alpha}-methylene-{\gamma}-butyrolactone$ group, were exhibited strong activity to Gram(+) bacteria than Gram(-) bacteria. In the antifungal test, Rhizoctonia solani and Phytophthora capsici known as phytopathogenic fungi have exhibited all extensive activity about compounds that have ${\alpha}-methylene-{\gamma}-butyrolactone$ group.

쑥갓(Chrysanthemum coronapium L.)의 꽃에서 분리한 13개의 sesequiterpene lactone들에 대한 생리활성 실험의 일환으로, 세균 8종과 곰팡이 5종을 이용하여 항미생물 활성을 검토하였다. 그 결과, 항세균 실험에서 Gram 양성균인 Bacillus subtilis, Bacillus cereus, Staphylococcus aureus 균들과 Gram 음성균인 Vibrio parahaemolyticus균이 쑥갓에서 분리된 13종의 화합물들에 대하여 광범위한 활성을 나타내었으며, 이들 중에 dihydrochrysanolide 유도체가 Staphylococcus aureus균에서 $3.1\;{\mu}g{\cdot}disc^{-1}$이하의 강한 항세균 활성을 보였다. 항진균 실험에서는 ${\alpha}-methylene-{\gamma}-butyrolactone$ group을 가진 화합물들이 Rhizoctonia solani와 Phytophthora capsici에 대해 강한 항진균 활성이 조사되었다.

Keywords

References

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