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Antimicrobial Activities of Sesquiterpene Lactones Isolated from the Flower of Chrysanthemum coronarium L.  

Ha, Tae-Jung (Institute of Agriculture and Life Science, Gyeongsang National University)
Han, Hyo-Shim (School of Natural Science, Sunchon National University)
Jang, Ki-Chang (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Jang, Dae-Sik (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Cho, Dong-Young (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Yang, Min-Suk (Institute of Agriculture and Life Sciences,Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
Lee, Kyung-Dong (Institute of Agriculture and Life Science, Gyeongsang National University)
Publication Information
Applied Biological Chemistry / v.46, no.3, 2003 , pp. 235-239 More about this Journal
Abstract
Thirteen sesquiterpene lactones isolated from the flower of Chrysanthemum coronarium L., which has been widely cultivated in Korea as a vegetable for a long time, were investigated their antimicrobial activities against eight bacteria and five phytopathogenic fungi. The antimicrobial activities of dihydrochrysanolide (6) and 1-epi-dihydrochrysanolide (7) showed strong activities against all the bacteria such as Bacillus subtilis, Bacillus cereus, Staphylococcus aureus and Vibrio parahaemolyticus. Especially, Staphylococcus aureus was investigated that have very strong antibacterial activity to $1.56\;{\mu}g{\cdot}disc^{-1}$, respectively. Also, most of sesquiterpene lactones, which have ${\alpha}-methylene-{\gamma}-butyrolactone$ group, were exhibited strong activity to Gram(+) bacteria than Gram(-) bacteria. In the antifungal test, Rhizoctonia solani and Phytophthora capsici known as phytopathogenic fungi have exhibited all extensive activity about compounds that have ${\alpha}-methylene-{\gamma}-butyrolactone$ group.
Keywords
Chrysanthemum coronarium L.; sesquiterpene lactone; antimicrobial activity;
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