Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Isolation and Identification of Terpenoids from the Leaf of Chrysanthemum coronarium L.

쑥갓 잎에서 터펜노이드계 화합물의 분리 및 동정

  • Ha, Tae-Joung (Institute of Agriculture and Life Science and Division of Applied Life Science, Gyeongsang National University) ;
  • Lee, Byong-Won (Division of Applied Life Science, Gyeongsang National University) ;
  • Lee, Jong-Rok (Division of Applied Life Science, Gyeongsang National University) ;
  • Lee, Jun (Division of Applied Life Science, Gyeongsang National University) ;
  • Hwang, Sun-Woo (Division of Applied Life Science, Gyeongsang National University) ;
  • Cho, Dong-Young (Division of Applied Life Science, Gyeongsang National University) ;
  • Nam, Sang-Hae (Department of Food Processing, Jinju National University) ;
  • Yang, Min-Suk (Institute of Agriculture and Life Science and Division of Applied Life Science, Gyeongsang National University) ;
  • Lee, Kyung-Dong (Institute of Agriculture and Life Science and Division of Applied Life Science, Gyeongsang National University)
  • 하태정 (경상대학교 농업생명과학원,경상대학교 응용생명과학원) ;
  • 이병원 (경상대학교 응용생명과학원) ;
  • 이종록 (경상대학교 응용생명과학원) ;
  • 이준 (경상대학교 응용생명과학원) ;
  • 황선우 (경상대학교 응용생명과학원) ;
  • 조동령 (경상대학교 응용생명과학원) ;
  • 남상해 (진주산업대학교 식품가공학과) ;
  • 양민석 (경상대학교 농업생명과학원,경상대학교 응용생명과학원) ;
  • 이경동 (경상대학교 농업생명과학원,경상대학교 응용생명과학원)
  • Published : 2003.02.28
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Abstract

Three terpenoids were isolated from the leaves of Chrysanthemum coronarium L. by silica gel chromatography and recrystalization. The structure of compounds 1, 2, and 3, using various spectroscopic data, were identified as to be terpenoid derivatives of dihydrotulipinolide, loliolide, and $5{\alpha},8{\alpha}-peroxyergosterol$, respectively. The presence of these 3 is the first time reported in this plant. The cytotoxic activity of $5{\alpha},8{\alpha}-peroxyergosterol$ showed strong activities against human cancer cell lines such as A549, PC-3, and HCT 116.

쑥갓(Chrysanthemum coronarium L.) 잎으로부터 생리활성 성분을 가진 3풀의 화합물을 분리하여 다양한 spectral data를 종합한 결과, 화합물 1, 2, 3은 terpenoid의 일종인 monoterpene lactone, sesequiterpene lactone과 sterol 화합물인 것으로 밝혀졌으며, 이들은 각각 dihydrotulipinolide, loliolide, $5{\alpha},8{\alpha}-peroxyergosterol$로 동정되었다. 이 화합물들은 쑥갓에서 처음으로 분리-보고되는 화합물이다. 분리된 화합물들의 세포독성을 측정한 결과, 화합물 3은 3종의 인체암 세포주에 대하여 비교적 강한 활성을 나타내었다.

Keywords

References

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