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Isolation and Identification of Terpenoids from the Leaf of Chrysanthemum coronarium L.  

Ha, Tae-Joung (Institute of Agriculture and Life Science and Division of Applied Life Science, Gyeongsang National University)
Lee, Byong-Won (Division of Applied Life Science, Gyeongsang National University)
Lee, Jong-Rok (Division of Applied Life Science, Gyeongsang National University)
Lee, Jun (Division of Applied Life Science, Gyeongsang National University)
Hwang, Sun-Woo (Division of Applied Life Science, Gyeongsang National University)
Cho, Dong-Young (Division of Applied Life Science, Gyeongsang National University)
Nam, Sang-Hae (Department of Food Processing, Jinju National University)
Yang, Min-Suk (Institute of Agriculture and Life Science and Division of Applied Life Science, Gyeongsang National University)
Lee, Kyung-Dong (Institute of Agriculture and Life Science and Division of Applied Life Science, Gyeongsang National University)
Publication Information
Applied Biological Chemistry / v.46, no.1, 2003 , pp. 55-59 More about this Journal
Abstract
Three terpenoids were isolated from the leaves of Chrysanthemum coronarium L. by silica gel chromatography and recrystalization. The structure of compounds 1, 2, and 3, using various spectroscopic data, were identified as to be terpenoid derivatives of dihydrotulipinolide, loliolide, and $5{\alpha},8{\alpha}-peroxyergosterol$, respectively. The presence of these 3 is the first time reported in this plant. The cytotoxic activity of $5{\alpha},8{\alpha}-peroxyergosterol$ showed strong activities against human cancer cell lines such as A549, PC-3, and HCT 116.
Keywords
Chrysanthemum coronarium L.; terpenoid; cytotoxicity;
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