Water Extract from Cornis Fructus Regulates Melanogenesis in B16/F10 Melanoma

산수유 물추출물이 B16/F10 Melanoma세포주의 멜라닌 생성에 미치는 영향

  • Yang Hyun Ok (Department of BCosmetics, Wonkwang Health Science College) ;
  • Choi Won Young (Department of Herbal Rresources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine Wonkwang University) ;
  • Baek Seung Hwa (Department of Herbal Rresources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Chun Hyun Ja (Department of Herbal Rresources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 양현옥 (원광보건대학 미용피부관리과) ;
  • 최원형 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 천현자 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2002.08.01

Abstract

Fruits of Cornus Officinalis have been used as an astrinent, tonic and haemostatic in chinese medicine, contain a large amount of hydrolyzable tannins. The main aim of the present study was to examine the effect of Corni Fructus on melanogenesis. Cells were cultured in the presence of water extracts from Corni Fructus for 48 h, and there were estimated total melanin content as a final product and activity of tyrosinase, a key enzyme, in melanogenesis. Water extract from Corni Fructus increased the melanin content and tyrosinase activity in a dose-dependent mammer. Especially, It was observed that 100 μg/ml only water extract stimulated melanin secretion in B16/F10 melanoma cells by 130% at 48 h treatment and activity of tyrosinase increased by 160% in presence of same concentration.

Keywords

References

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