Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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A Study on the Effects of Sopunghwalhyeoltang-gamibang on the Inhibition of Arthritis Induced by Collagen on the Mouse

소풍활혈탕가미방이 Collagen으로 수발된 생쥐의 관절염 억제에 관한 연구

  • Gwak Jung Mun (Department of Oriental Rehabilitation. College of Oriental Medicine, Daejeon University) ;
  • Oh Min Suck (Department of Oriental Rehabilitation. College of Oriental Medicine, Daejeon University) ;
  • Park Jong Ho (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Kim Dong Hee (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
  • 곽중문 (대전대학교 한의과대학 재활의학교실) ;
  • 오민석 (대전대학교 한의과대학 재활의학교실) ;
  • 박종오 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2002.08.01
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Abstract

This study was carried out to know the effects of sopunghwalhyeoltang-gamibang(hereinafter referred to SPHHT) on the inhibition of arthritis induced by collagen on the mouse. Various experimental were performed in vivo (in DBA/1 J mice which are experimental model of arthritis induced by collagen) to analyse the immunomodulatory effects of SPHHT. The results were obtained as follows: 1. The cytotoxicity against mLFC was not measured in all concentration. 2. The arthritis index, incidence, hind paw edema, delayed-type hypersensitivity reaction, spleen weight were reduced in SPHHT treated group. 3. The expression of CD3 ε +/CD4+, CD3 ε +/CD8+ and CD19+ in peripheral blood mononuclear were reduced in SPHHT treated group. 4. The production of pro-inflammatory cytokines such as IL-6 and TNF-α were significantly reduced in SPHHT treated group. 5. The formation of new bones and synivium were stimulated in SPHHT treated group. Comparison of the results for this study showed that Sopung-hwalhyeoltang-gamibang had immunomodulatory effects. So we expect that Sopunghwalhyeoltang-gamibang should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

Keywords

References

  1. 면역학 서울대학교의과대학
  2. 痺證 權宰植(外4人)
  3. 診療要鑑 金定濟
  4. 增補韓方臨床40年 朴柄昆
  5. 常見病症辨症診治槪要 白洪龍
  6. 沈氏尊生書 沈金鰲
  7. 東醫寶鑑 許浚
  8. 證脈方藥合編 黃度淵
  9. 원광대학교대학원 학위논문 疏風活血湯이 家兎의 腎臟 기능에 미치는 영향 尹用甲
  10. 원광대학교대학원 疏風活血湯 전탕액이 XO/HX에 의해 손상된 배양 脊髓感覺神經細胞에 미치는 영향 楊慶錫
  11. 경희대학교대학원 학위논문 歷節風에 응용되는 疏風活血湯의 소염, 진통, 해열 효과에 관한 연구 남영
  12. 원광대학교대학원 학위논문 鍼灸刺戟 및 疏風活血湯加味方 투여가 류마티스성 관절염 환자의 혈액에 미치는 영향 안선준
  13. 本草學 전국한의과대학 본초학교수(공편)
  14. 한방병원처방집 대전대학교한방병원
  15. J. Immunological method. v.208 Optimization of the sulforhodamine B(SRB) Colormetric assay Papazissi, K.;geromichalos, D.;Dimitriadis, K.;Kortssaris, H.
  16. Clin Immunol.Immunopathol. v.86 Taxol involution of collagen-induced arthritis: ultrastructural correlation of synovitis and neovascularization. Arsenault, A. L.;Lhotak, S.;Hunter,W.L.;Banquerigo, M.L.;Brahn, E.
  17. Bio. Pharm. Bull. v.20 no.11 Arthritis index Yuko
  18. The journal of Immunology v.144 no.10 An antigen-specific DTH-initiating cell clone. Functional, phenotypical, and partial molecular characterization W.R. Herzog;I. Millet;N.R. Ferreri,;R. Ramabhadran;J. Schreurs; P.W. Askense
  19. 대한의학협회지 v.35 no.10 류머티스 관절염의 병인 김호연
  20. Cecil Textbook of Medicine James, B.;Wyngaarden
  21. 黃帝內經素問譯解 楊維傑(編著)
  22. 금궤요략방론 張仲景
  23. 諸病源候論 巢元方
  24. 外臺秘要方 王燾
  25. 三因方 v.3 陳無擇
  26. 경희대학교대학원 학위논문 농도에 따른 加味疏風活血湯 水鍼이 흰쥐의 Adjuvant 관절염에 미치는 영향 김정진
  27. 경희대학교대학원 학위논문 加味疏風活血湯 水鍼이 Adjuvant 관절염에 미치는 영향 송언석
  28. Clin Immunol Immunopathol v.73 no.1 Collagen-induced arthritis as a model of rheumatoid arthritis Durie, F.H.;Fava, R.A.;Noelle, R.J.
  29. Clin Exp Immunol v.89 no.2 Acceleration of onset of collagen-induced arthritis by intra-articular injection of tumour necrosis factor or transforming growth factor-beta Cooper, W.O.;Fava, R.A.;Gates, C.A.;Cremer, M.A.;Townes, A.S.
  30. Arthritis Rheum v.32 no.2 Enhanced production of interleukin-6 in mice with type II collagen-induced arthritis Takai, Y.;Seki, N.;Senoh, H.;Yokota, T.;Lee, F.;Hamaoka, T.; Fujiwara, H.
  31. J Immunol 1 v.161 no.3 Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor Kageyama, Y.;Koide, Y.;Yoshida, A.;Uchijima, M.;Arai, T.;Miyamoto, S.;Ozeki, T.;Hiyoshi, M,;Kushida, K.; Inoue, T.
  32. Eur J Immunol v.29 no.7 Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis Butler, DM.;Malfait, AM.;Maini, RN.;Brennan, FM.; Feldmann, M.
  33. 면역의 의미론 황상익(역)
  34. 신면역학입문 오찬호(역)
  35. Arthritis Rheum v.42 no.8 Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice Sasai, M.;Saeki, Y.;Ohshima, S.;Nishioka, K.;Mima, T.;Tanaka, T.;Katada, Y.;Yoshizaki, K.;Suemura, M.; Kishimoto, T.