Browse > Article

Water Extract from Cornis Fructus Regulates Melanogenesis in B16/F10 Melanoma  

Yang Hyun Ok (Department of BCosmetics, Wonkwang Health Science College)
Choi Won Young (Department of Herbal Rresources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Jeon Byung Hun (Department of Pathology, College of Oriental Medicine Wonkwang University)
Baek Seung Hwa (Department of Herbal Rresources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Chun Hyun Ja (Department of Herbal Rresources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.4, 2002 , pp. 818-822 More about this Journal
Abstract
Fruits of Cornus Officinalis have been used as an astrinent, tonic and haemostatic in chinese medicine, contain a large amount of hydrolyzable tannins. The main aim of the present study was to examine the effect of Corni Fructus on melanogenesis. Cells were cultured in the presence of water extracts from Corni Fructus for 48 h, and there were estimated total melanin content as a final product and activity of tyrosinase, a key enzyme, in melanogenesis. Water extract from Corni Fructus increased the melanin content and tyrosinase activity in a dose-dependent mammer. Especially, It was observed that 100 μg/ml only water extract stimulated melanin secretion in B16/F10 melanoma cells by 130% at 48 h treatment and activity of tyrosinase increased by 160% in presence of same concentration.
Keywords
Cornis Fructus; Melanogenesis; Tyrosinase;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Rapid colorimetric assay for the cellular growth and survival : application to proliferation and cytotoxic assay. /
[ Mosmann T. ] / J. Immun. Methods
2 /
[ 정진섭;신민교 ] / 도해 생약대사전
3 /
[ 장삼문;최정;김종완;박병윤;박선동 ] / 한약자원식물학
4 /
[ 전통의학연구소 ] / 본초약재 도감
5 /
[ 김창민(외) ] / 중약대사전
6 /
[ 김재길(외) ] / 동양전통약물 원색도감
7 Chemical compositions of Corni Fructus and separating properties of its flesh by drying. /
[ Lee, Y. C.;Kim, Y. E.;Lee, B. Y.; Kim, C. J. ] / Kor. J. Food Sci. Technol.
8 Isolation of inhibitory components on tyrosinase activity from the bark of Pawonia moutan. /
[ Lee, S.H.;Park, J.S.;Kim, S.Y.;Kim, J.J.;Chung, S.R. ] / J. Pharm. Soc. Kor.
9 Antimicrobial and Antioxidative activities of fructus extracts. /
[ Seo, K. I.;Lee, S. W.; Yang, K. H. ] / Kor. J. Postharvest Sci. Tec.
10 Pharmacological studies on Ether fraction of Corni Fructus. /
[ Lee, E. B.;Choi, B. C.; Cho, T. S. ] / J. Pharm. Soc. Kor.
11 The isolation of inhibitory constituents on melanin polymer formation from the leaves of Cercis chinensis. /
[ Lee, S.H.;Kim, S.Y.;Kim, J.J.;Jang, T.S.; Chung, S.R ] / Kor. J. Phamacogn.
12 The screening of the inhibitory compounds on tyrosinase activity from the natural product. /
[ Lee, S.H.;Park, J.S.;Kim, S.Y.;Kim, J.J.; Chung, S.R. ] / J. Pharm. Soc. Kor.
13 Effect of tyrosinase inhibitors on the melanogenesis og gold fish. /
[ Han, D.S.;Jung, S.W.;Kim, S.J.;Kim, S.H.;Ahn, B.H. ] / Kor. J. Food Sci. Technol.
14 Melanogenesis of stem cell factor in depigmented patch of vitiligo. /
[ Ro, S.W.;Seong, S.J.;Kim, M.N.;Hong, C.K.;Ro, B.I. ] / Kor. J. Invest. Dermatol.
15 Effect of the aqueous extract of Epimedium koreanum Nakai on melanin formation in B16 mouse melanoma cell line. /
[ Chun H. J.;Mun Y. J.;Kim J. H.;Kim I. K.;Jeon B. H.;Woo W. H. ] / J. Pharm. Soc. Korea
16 Inhibitory effects on retinoic acid and melanization of B16 melanoma cell by Epimedium koreanum Nakai and a-MSH. /
[ Chun H. J.;Kim I. K.;Woo W. H. ] / J. Kor. Chem. Soc.
17 Inhibitory effects of Atractylodies Rhizoma alba on melanin biosynthesis /
[ Chun, H. J.;Choi, E. Y.;Yoon, S. C.;Nam, H. W.;Woo, W. H. ] / J. Pharm. Soc. Korea
18 Regulation of melanin synthesis of B16 mouse melanoma cells by 1 a-25-dihydroxyvitamin D3 and retinoic acid. /
[ Hosoi J.;Abe E.;Suda T.;Kuroki T. ] / Cancer Res.
19 Mechanisms and melanogenesis inhibition by tumor necrosis factor-a in B16/F10 mouse melanoma cells. /
[ Matinez-Esparza M. ] / Eur. J. Biochem.
20 Biosynthesis and function of fungal melanin. /
[ Bell, A.A.;Weeler, M.H. ] / Ann. Rev. phytophathol.   ScienceOn
21 Biochemical control of melanogenesis and melanosomal organi-zation. /
[ Hearing V. J. ] / Soc. Invest. Dermatol.   ScienceOn
22 Biology of melanocytes. /
[ Jimbow K;Queredo Jr WC;Prota G;Fitzpatric TB.;Freedberg IM;Eisen AZ;Wolff KW(et al)(Eds.) ] / Dermatology in genera medicine
23 The effect of arbumin, medimim C and Pinellia ternata extract on the pigmentary system. /
[ Doh, K. S.;Yoon, J. S.;Park, S. G.;Cho, W. G.;Jang, M. S.;Suh, K. S.;Kim, S. T. ] / Kor. J. Invest. Dermatol.
24 Screening of the tyrosinase inhibitors from marine algae and medicinal plants. /
[ Choi, B.W.;Lee, B.H.;Kang, K.J.;Lee, E.S.;Lee, N.H. ] / Kor J. Phamcogn.
25 /
[ 강원형;이은소;전세정;이맹로;전우현 ] / 대한피부과학회 초록집
26 Study on the constituents of Cornus Offinalis Sieb. et Zucc. /
[ Endo, T.;Taguchi, H. ] / Yakugaku Zasshi
27 Constituents of the fruits of Cornus Officinalis. /
[ Yang, T. H.;Liu, S. H.; Sun, M.H. ] / Taiwan Yao Hsueh Tsa Chih