Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Genotoxic Effects of Volatile Organic Compounds in Water

물속 휘발성 유기화합물이 염색체 돌연변이에 미치는 영향

  • Jung Kyu Saeng (Graduate School of Public Health, Kyungpook National University) ;
  • Lee Chae Yang (Department of Occupational & Environmental Medicine, Kumi CHA Medical Center, College of Medicine Pochon CHA University) ;
  • Shin Heuyn Kil (School of Bioscience and Food Technology, Handong University) ;
  • Lee Ki Nam (Department of The 3rd Medicine. Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jeung Jae Yeal (Department of The 3rd Medicine. Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Jong Young (Department of Preventive Medicine. School of Medicine, Kyungpook National University)
  • 정규생 (경북대학교 대학원 보건학과) ;
  • 이채용 (포천중문의과대학 구미차병원 산업의학과) ;
  • 신현길 (한동대학교 생물식품공학부) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과) ;
  • 정재열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이종영 (경북대학교 의과대학 예방의학교실)
  • Published : 2002.10.01
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Abstract

For determination of the genotoxicity of VOCs(Volatile Organic Compounds) in water, in vitro Comet assay was performed using 3T3 cells. The selected 5 VOCs; Trichloroethylene(TCE), Tetrachloroethylene(PCE), Carbontetrachloride (CteC), Dichloromethane(DCM) and Chlorofrom(Chl) and mixed solvent(Mix), are the test items for drinking water quality. Author analyzed the genotoxicity of these solvents through their tail length (TL) values. Mix, PCE, Chl, TCE in order had cytotoxicity at the highest concentration, and CCl₄ and DCM had no cytotoxic effect. TCE, CCl₄, Chl, PCE, Mix, DCM had genotoxicity, Chl, PCE, Mix had both cytotoxicity and genotoxicity simultaneously, Cytotoxic effect of mixed organic solvents, compared with that of single component, at each concentration, was influenced by the synergistic effect of the interaction of each organic component.

Keywords

References

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