Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

Coumarins from Angelica gigas Roots having Rat Lens Aldose Reductase Activity

  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
  • Published : 2002.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Systematic fractionation of Angelica gigas roots led to the isolation of linear coumarins such as decursinol angelate, decursin and nodakenin. These compounds were tested for their effects on rat lens aldose reductase. Nodakenin was demonstrated to exhibit significant inhibition of rat lens aldose reductase activity with $IC_{50}$ value of $7.33\Mu\textrm{M}$.

Keywords

References

  1. Ahn, K S., Sim, W S. and Kim, I H. (1996). Decursin: a cyto-toxic agent and protein kinase C activator from the root of Angelica gisas. Planta Med. 62, 7-9 https://doi.org/10.1055/s-2006-957785
  2. Ahn, K-S., Sim, W-S., Lee, I-K., Seu, Y-B. and Kim, I-H. (1997). Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 63, 360-361
  3. Alda, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M. and Mitsuhashi, H. (1990). Isoli-qumtigenin: A new aldose reductase inhibitor from Glycyr-rhizae radix. Planta Med. 57, 254-258
  4. Beyer-Mears, A. and Cruz, E. (1985). Reversal of diabetic cat-aract by sorbinil, an aldose reductase inhibitor. Diabetes 34, 15-21 https://doi.org/10.2337/diabetes.34.1.15
  5. Brubaker, A. N., Ruiter, J. D. and Whitmer, W. L. (1986). Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones. J. Med. Chem. 29, 1094-1099 https://doi.org/10.1021/jm00156a031
  6. Hayman, S. and Kinoshita, J. H. (1965). Isolation and proper-ties of lens aldose reductase. J. Biol. Chem. 240, 877-882
  7. Inagaki, K., Miwa, I. and Okuda, J. (1982). Affnity purifica-tion and glucose specificity of aldose reductase from bovine lens. Arch. Biochem. Biophys. 216, 337-344 https://doi.org/10.1016/0003-9861(82)90219-3
  8. Kang, S. Y., Lee, K. Y., Sung, S. H., Park, M. J. and Kim, Y. C. (2001), Coumarins isolated from Angelica gigas inhibit acetyl cholinesterase: structure-activity relationships. J. Nat. Prod. 64, 683-685 https://doi.org/10.1021/np000441w
  9. Kim, H-S., Park, J-S., Park, H-J. and Chi, H-J. (1980). A study of the effects of the root components of AngeIica gigas Nakai on voluntary activity in mice. Kor. J. Pharma-cogn. 11, 11-14
  10. Kinoshita, J. H. and Nishimura, C. (1988). The involvement of aldose reductase in diabetic complications. Diabetes/Metab-oIism Rev. 4, 323-337 https://doi.org/10.1002/dmr.5610040403
  11. Konoshima, M., Chi, H-J. and Hata, K. (1968). Coumarins from the root of Angelica sisas Nakai. Chem. Pharm. BuII. 16,1139-1140 https://doi.org/10.1248/cpb.16.1139
  12. Lee, S., Kang, S. S. and Shin, K. H. (2002). Coumarins and a pyrimidine trom the roots of AngeIica eigas. Nat. Prod. Sci. (Accepted for publication)
  13. Moon, C-K., Lee, S-C., Yun, Y-R, Ha, B-J, and Yook, C-S. (1988). Effects of some coumarin derivatives on the bovine lens aldose reductase activily. Arch. Pharm. Res. 11, 308-311 https://doi.org/10.1007/BF02857767
  14. Pachaly, P., Treitner, A. and Sin, K. S. (1996). Neue Cumar-inglykoside aus Angelica gigas. Pharmazie 51, 57-61
  15. Raskin, P. aiid Rosentstock, J. (1987). Aldose reductase inhib-itors and diabetic complications. Am. J. Med. 83, 298-306 https://doi.org/10.1016/0002-9343(87)90702-9
  16. Ryu, K. S., Hong, N. D., Kim, N. J. and Kong, Y. Y. (1990). Studies on the coumarin constituents of the root of AngeI-ica gigas Nakai Isolation of decursinol angelate and assay of decursinol angelate and decursin. Kor. J. Pharmacogn. 21, 64-68
  17. Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K. and Hashimoto, Y. (1984). Inhibition of lens aldose reductase by flavonoids. Phy-tochemistry 23, 1885-1888
  18. Shin, K. H., Chung, M. S., Chae, Y. J., Yoon, K. Y. and Cho, T. S. (1993). A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64, 130-133
  19. Shin, K. H., Kang, S. S., Kim, H. J. and Shin, S. W. (1994). Isolation of an aldose reductase inhibitor from the fruits of Vitex rotundifolia. Phytomed. 1, 145-147 https://doi.org/10.1016/S0944-7113(11)80033-4
  20. Shin, K. H., Kang, S. S., Seo, E. A. and Shin, S. W. (1995). Isolation of aldose reductase inhibitors from the flowers of Chrysanthemum boreale. Arch. Pharm. Res- 18, 65-68 https://doi.org/10.1007/BF02979135
  21. Terashima, H., Hama, K., Yamamoto, R., Tsuboshima, M., Kikkawa, R., Hatanaka, J. and Shigeta, Y. (1984). Effects of a new aldose reductase inhibitor on various tissues in vitro. J. Pharm. Exp. Ther. 229, 226-230
  22. Yook, C. S. (1990). 'Coloured medicinal plants of Korea', Academy Book Co., Seoul, p. 390