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Coumarins from Angelica gigas Roots having Rat Lens Aldose Reductase Activity  

Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University)
Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University)
Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University)
Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
Publication Information
Biomolecules & Therapeutics / v.10, no.2, 2002 , pp. 85-88 More about this Journal
Abstract
Systematic fractionation of Angelica gigas roots led to the isolation of linear coumarins such as decursinol angelate, decursin and nodakenin. These compounds were tested for their effects on rat lens aldose reductase. Nodakenin was demonstrated to exhibit significant inhibition of rat lens aldose reductase activity with $IC_{50}$ value of $7.33\Mu\textrm{M}$.
Keywords
Angelica gigas; Umbelliferae; rat lens aldose reductase activity; coumarin; nodakenin;
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