Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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General Pharmacology of KI-60606

KI-60606의 일반약리작용시험

  • 김은주 (대전광역시 유성구 장동 100 한국화학연구원 부설 안전성평가연구소) ;
  • 김현진 (대전광역시 유성구 장동 100 한국화학연구원 부설 안전성평가연구소) ;
  • 김동연 (경기도 용인시 기흥읍 보라리 359 일양약품주식회사 중앙연구소)
  • Published : 2002.06.01
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Abstract

In this study general pharmacological profiles of KI-60606 on the central nervous system, the cardiovascular system and the other organs were investigated. The dosages given were 0,5, 10 and 25 mg/kg and drugs were administered intravenously. The animals used for this study were mice, rats, cats and guinea pigs. KI-60606 showed no effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced hypnosis time, body temperature, analgesic activity, anticonvulsant activity and contraction of nictitating membrane in cats. Furthermore KI-60606 showed no effects on blood pressure, heart rate, LVP (left ventricular peak systolic pressure), LVEDP (left ventricular end diastolic pressure), LVDP (left ventricular developing pressure), DP(double product), CFR(coronary flow rate), smooth muscle contraction using guinea pig ileum and gastric secretion at all dosage tested except the increase of gastrointestinal transport and urinary $K^+$ excretion.

Keywords

References

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