The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Artemisiae Capillaris Fructus on Experimental Liver Damage by $CCl_4$

인진호(茵蔯蒿)의 열수 및 메탄올, 에테르, 부탄올 추출물이 $CCl_4$유발에 의한 간독성(肝毒性) 억제(抑制)에 미치는 영향

  • Lee, Chea-Jung (Dept. of Oriental Medicine, Dongguk University) ;
  • Kim, Hyoung-Hwan (Dept. of Oriental Medicine, Dongguk University) ;
  • Kim, Cheol-Ho (Dept. of Oriental Medicine, Biochemistry and molecular biology, Dongguk University) ;
  • Kim, Jong-Dae (동국대학교 한의과대학 내과학교실)
  • 이채중 (동국대학교 한의과대학 내과학교실) ;
  • 김형환 (동국대학교 한의과대학 내과학교실) ;
  • 김철호 (동국대학교 한의과대학 생화학교실) ;
  • 김종대 (Dept. of Oriental Medicine, Dongguk University)
  • Published : 2000.08.30
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Abstract

Objective : To investigate the effects of Artemisiae Capillaris Fructus on liver injury induced $CCl_4$. Method : Carbon tetrachloride-induced hepatic injury in $CCl_4$,-treated rats caused changes in the glutamic oxaloacetic transaminase(GOT), glutamic pyruvic transaminase(GPT) and alkaline phosphatase(ALP) activities in the serum. Result : The Methanol extract of the Artemisiae Capillaris Fructus was found to protect the rats against such changes significantly. Protective activities were shown to be present in ether-soluble and buthanol-soluble fractions prepared from the above methanol extract. Conclusion : we have examined the detoxyfying effect, one of several medicinal effects of Artemisiae Capillaris Fructus. on liver disorder experimentally induced by $CCl_4$. as an animal model of liver disorder.

Keywords

References

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