Hypoglycemic Effect of GE974 isolated from Gyrophora esculenta in Normal and Diabetic mice

석이에서 분리한 GE974의 혈당상승억제효과

GE974, isolated from Gyrophora esculenta, showed significant inhibitory effect on several ${\alpha}-glucosidases$ in vitro in previous study. In the present study, GE974 showed significant inhibitory effect on blood glucose elevation in mice loaded with maltose, sucrose, starch and lactose. Also, it exhibited similar effect in alloxan and streptozotocin induced diabetic mice, and genetic diabetic mice(db/db mice) loaded with maltose in dose dependent manner. These results suggest that GE974 may possess hypoglycemic effect that inhibit competitively ${\alpha}-glucosidase$ activities.