Toxicological Research

  • 제15권1호
  • /
  • Pages.1-8
  • /
  • 1999
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

미나리 추출물이 마우스의 장기내 수은 축적에 미치는 영향

Effects of Oenanthe javanica Extracts on Mercury Accumulation in Organs of the Mouse

  • 조현욱 (순천대학교 자연대 생물학과) ;
  • 김명훈 (광주보건전문대학 물리치료과) ;
  • 황규영 (순천대학교 자연대 생물학과) ;
  • 민병운 (광양대학 임상병리학과) ;
  • 박종철 (순천대학교 자연대 한약자원학과) ;
  • 김종홍 (순천대학교 자연대 생물학과)
  • 발행 : 1999.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was performed to investigate the antitoxic effect of Oenanthe javanica extracts on orally administered mercury compound. Adult male ICR mice were exposed to methylmercuric chloride (CH3HgCl)through drinking water. The control, mercury treated and Oenanthe javanica treated groups not showed significant differences in mean body and organ weights of mice. The distribution of mercury in the cerebellum, kidney, liver and spleen of the mouse were examined according to a histochemical mathod. Grains of mercury traces were located in the purkinje cell and granular layers of the cerebellum and cortex of kidney respectively. Lesser staining of the grains was seen in the collecting tubules of medulla. in the liver, mercury accumulations were present primarily in the hepatocytes around portal area containing interlobular bile duct, artery and portal vein. Also grains of mercury traces were accumulated in the white pulp of the spleen. In the group of Oenanthe javanica extracts, staining intensity of mercury was decreased in the Purkinje cell layer of cerebellum and in the portal area of liver respectively. Staining patterns in kidney and spleen of extracts group were similar to that of only mercury treated group.

키워드

참고문헌

  1. Pharmacol. Toxicol. v.64 Methymercury uptake caross bovine brain capillary endothelialcells in vitro. Thr role of amino acids Aschner, M.;Clarkson, T.W.
  2. Environ. Res. v.14 Neurotoxic effects of mercury-areview Chang, L.W.
  3. J. Histochemistry v.17 Autometallographic localization of synaptic vesicular zinc and lysosmal gold, silver and mercury Danscher, G.;Montagnese, C.
  4. Histochemical J. v.18 Differentiation of hitochemically visualized mercury and silver Danscher, G.;Rungby, J.
  5. Biosci. Biotechnol. Biochem. v.59 A new phenylpropanoid glucoside and other constituents of Oenanthe javanica Fujita, T.;Kadoya, Y.;Aota, H.;Nakayama, M.
  6. Acand. J. Immunol. v.41 In-terleukin-4 gene expression in mercury-induced autoimmunity Gillespie, K.M.;Qasim, F.J.;Tibbatts, L.M.;Thiru, S.;Oliveira, D.B.;Mathieson, P.W.
  7. Biochem. Pharmacol. v.34 Effect of combind administration of thiol compounds and methylmercury chloride on mercury distubution in rats Hirayama, K.L.
  8. Immunology v.90 Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-response and ashift of the interleukin profile Hu, H.;Abedi-Velugerdi, M.;Moller, G.
  9. FASEB J. v.8 Adverse immunilogical effects adn autoimmunity induced by dental amalgam and alloy in mice Hultman, P.;Johansson, U.;Turley, S.J.;Lindh, U.;Enestrom, S.;Pollard, K.M.
  10. Chung Kuo Chung Yao Tsa Chih. v.15 Antiarrhythmic effect of Oenanthe javanica DC injection Ji, G.;Yao, X.;Zang, Z.;Huang, Z.
  11. J. Nutr. v.116 Lead toxicity in chicks: Interaction with dietary methionine and choline Latta, D.M.;Donaldson, W.F.
  12. In vitro Cell. Dev. Biol. v.26 Rat primary hepatocyte culture are good model for examining metallothinoein-induced tolerance to cadmium toxicity Liu, J.;Kershaw, W.C.;Klaassen, C.D.
  13. J. Immunol. v.136 Autoimmunity induced by HgCl₂ in Brown-Norway rats. II.Monoclonal antibodies sharing specificities and idiotypes with mouse natural monoclonal antibodies Lymberi, P.;Hirsch, F.;Kuhn, J.;ternynck, T.;Druet, P.;Avrameas, S.
  14. Biometals v.9 Mercury distribution and renal metallothionein induction after subchronic oral exposure in rats Morcillo, M.A.;Santamaria, J.
  15. J. Histochem. Cytochem. v.37 Silver enhancement of tissue mercury: Demonstration if mercury in autometallographic silver grains from rat kidneys Nφrgaard, J.O.R.;Mφller-Madsen, B.;Hertel, N.;Danscher, G.
  16. Experientia v.23 The protective effects of small amounts of selenite n sublimate in-toxication Parizek, J.;Ostadalova, I.
  17. Plannta Medica v.61 Isorhamnetin sulphate from the leaves and stems of Oenanthe javanica in Korea Park, J.C.;Young, H.S.;Yu, Y.B.;Lee, J.H.
  18. Planta Medica v.62 Protective effect of Oenanthe javanica on the hepatic lipid peroxidation in bromobenzene-treated rats and its bioactive component Park, J.C.;Yu, Y.B.;Lee, J.H.;Hattori, M.;Lee, C.K.;Choi, J.W.
  19. Virchows Archiv B Cell Pathol. v.61 Autometallographic detection of mercury in rat spinal cord after treatment with organic mercury Schiφnning, J.D.;Mφller-Madsen, B.
  20. Toxicol. Appl. Pharmacol. v.62 Effects if coad-ministered low- molecular weight thiol compounds on short-term distribution of methylercury in the rat Thomas, D.J.;Smith, C.J.
  21. Toxicol. Pathol. v.20 Histopathological effects in Poecilia reticulata (guppy) exposed to methyl mercury chloride Wester, P.W.;Canton, H.H.
  22. 한국독성학회지 v.12 한국산 생약으로부터 해독물질의 개발 (제 8보)-금은화 메탄올 분획이 흰쥐 장기내 카드뮴 축적과 metalllothionein 생성에 미치는 여향 김영옥;이종섭;박경옥;한두석;유일수;곽정숙;백승화
  23. 영남대학교 석사학위논문 미나리 추출물이 사염화탄소에 의한 간 손상에 미치는 영향 박용수
  24. 고려대학교 박사학위논문 마늘이 백서의 수은중독에 미치는 영향에 관한 연구 박재순
  25. 한국생약학회지 v.24 미나리의 steroid 및 flavonid 박종철;유영법;이종호
  26. 한국식품영양과학회지 v.26 식용 및 약용식물 추출물과 화합물이 흰쥐의 간장조직에서 과산화지질 생성에 미치는 영향 박종철;정신교;이종호;허종문;최명락;송상호;최종원
  27. 한국독성학회지 v.12 한국산 생약으로 부터 해독물질의 개발_제 6보)-금은화 메탄올 분획의 흰쥐 비장내 카드뮴 축적에 미치는 영향 백승화;김현주;김영옥;곽정숙;이종섭;박경옥;한두석;유일수
  28. 한국독성화학회지 v.12 카드뮴 중독에 대한 산두근 추출액의 해독효과에 관한 연구 이종섭;박경옥;이정미
  29. 한국독성학회지 v.13 오토메탈로그라피에 의한 마우스의 신장, 간장, 비장 및 소뇌에 축적된 수은의 검출 조현욱;김명훈;황규영;이성태