Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of High Molecular Weight Fractions of Aloe spp. on Alcohol Metabolism

Aloe속 식물의 고분자물질 분획이 알콜대사에 미치는 효과

  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
  • Chung, Ha-Sook (Natural Products Research Institute, Seoul National University) ;
  • Lim, Soon-Sung (Natural Products Research Institute, Seoul National University) ;
  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Shim, Chang-Sub (R & D Center, Kim Jeong Moon Aloe Co., LTD.) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
  • 한용남 (서울대학교 천연물과학연구소) ;
  • 정하숙 (서울대학교 천연물과학연구소) ;
  • 임순성 (서울대학교 천연물과학연구소) ;
  • 이상현 (서울대학교 천연물과학연구소) ;
  • 심창섭 ((주) 김정문알로에 중앙연구소) ;
  • 신국현 (서울대학교 천연물과학연구소)
  • Published : 1998.06.30
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Abstract

For the purpose of evaluating protective components against alcohol-induced toxicity, the active components enhancing alcohol metabolism was pursued from water soluble fraction by ethanol precipitation and DEAE-cellulose chromatographic technique. As a result, various high molecular weight fractions from Aloe vera and Aloe arborescens, on a single oral administration in rats were found to cause a significant decrease in the blood ethanol concentration as well as enhancement of liver cytosolic ADH and ALDH activities and among which, a strong acidic high molecular weight fraction was demonstrated to exhibit the most potent enhancing activity on ethanol metabolism.

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