Korean Journal of Veterinary Pathology (한국수의병리학회지)
- Volume 1 Issue 1
- /
- Pages.7-12
- /
- 1997
- /
- 1226-766X(pISSN)
Regeneration of Immune System after Syngeneic Bone Marrow Transplantation in Irradiated Mice: II. B Lymphocyte Regeneration and Antibody Production
마우스 동계골수이식 후 면역체계의 재생: II. B림프구의 재생 및 항체산생
-
Kim, Sung-Ho
(College of Veterinary Medicine, Chonnam National University)
;
- Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
- Lee, Song-Eun (College of Veterinary Medicine, Chonnam National University) ;
- Kim, Soon-Tae (Kyungpook Veterinary Service Laboratory) ;
-
Jo, Sung-Kee
(Korea Atomic Energy Research Institute)
;
-
Hyun, Byung-Hwa
(Korea Research Institute of Bioscience and Biotechnology)
;
- Ryu, Si-Yun (College of Veterinary Medicine, Chungnam National University) ;
- Daynes, Raymond A. (School of Medicine, University of Utah)
-
김성호
(전남대 수의과대학)
;
- 오헌 (전남대 수의과대학) ;
- 이송은 (전남대 수의과대학) ;
- 김순태 (경상북도 가축위생시험소) ;
-
조성기
(한국원자력연구소)
;
-
현병화
(생명공학연구소)
;
- 류시윤 (충남대학교 수의과대학) ;
- Published : 1997.04.01
Abstract
Lethally irradited C3H/HeN mice were transplanted with syngeneic bone marrow. The B cell regeneration levels of spontaneous serum Ig, fecal igA and specific ig to diphtheria toxoid were determined at various time points. The number of B220+ cells reached normal range at 4 weeks after bone marrow transplantation(BMT) in spleen and lymph node. The B cell number of spleen returned to normal relatively soon than in the lymph node. Within 5 to 7 weeks after BMT, the transplanted mice contained nearly normal levels of spontaneous serum IgA, IgG2b and fecal IgA, but 2 fold lower levels of serum IgG2a, IgM and IgG3. Especially IgG3 levels were within low-normal range throughout the study. One to two weeks after immunization the predominant anti-diphtheria toxoid subtype was IgM. The levels of specific serum Ig were very low and after booster immunization at week 6, the short-lasting increase of Ig production was notd.