Korean Journal of Veterinary Pathology (한국수의병리학회지)
- Volume 1 Issue 1
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- Pages.13-25
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- 1997
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- 1226-766X(pISSN)
A Study of aticarcinogenic effects of dimethyl disulfide and diallyl disulfide in a rat multi-organ carcinogenesis model
다장기 발암모델을 이용한 dimethyl disulfide와 diallyl disulfide의 항발암효과
- Kang, Boo-Hyon (Korea Research Institute of Chemical Technology, Screening & Toxicology Research Center) ;
- Son, Hwa-Young (Korea Research Institute of Chemical Technology, Screening & Toxicology Research Center) ;
- Ha, Chang-Su (Korea Research Institute of Chemical Technology, Screening & Toxicology Research Center) ;
- Rho, Jung-Koo (Korea Research Institute of Chemical Technology, Screening & Toxicology Research Center)
- 강부현 (한국화학연구소, 스크리닝-안전성연구센터) ;
- 손화영 (한국화학연구소, 스크리닝-안전성연구센터) ;
- 하창수 (한국화학연구소, 스크리닝-안전성연구센터) ;
- 노정구 (한국화학연구소, 스크리닝-안전성연구센터)
- Published : 1997.04.01
Abstract
The anticarcinogenic effects of dimethyl disulfide(DMDS, methyl disulfide)and diallyl disulfide(DADA, allyl disulfide) were studied in a 28 weeks rat multi-organ carcinogenesis model. neoplastic and preneoplastic lesions were observed in the liver kidney thyroid gland esophagus duodenum colon, rectum and adrenal gland. Tesults showed that neoplastic lesions in the kidney liver and thyroid gland were inhibited by DADS but those in the liver and colon were enhanced by DMDS when compared to positive control group. incidence of neoplastic lesions in the other organs were not changed by DMDS or DADS exposure. While GST-p positive foci in the liver were increased by DMDS, DADS had no effect. There was no significant histopathological lesion in DMDS or DADS treated group without pretreatment with carcinogens.