Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지

Effects of Feeding the Mixture of Linseed and Sunflower Seed Oil on the Lipid Components of Serum in Dietary Hyperlipidemic Rats

아마인유와 해바라기 종자유의 혼합급이가 식이성 고지혈증 흰쥐의 혈청 지질 성분에 미치는 영향

  • 최운정 (서강전문대학 식품영양학과) ;
  • 김한수 (경상대학교 식품영양학과) ;
  • 강정옥 (동의대학교 식품영양학과) ;
  • 김성희 (경상대학교 식품영양학과) ;
  • 서인숙 (경상대학교 식품영양학과) ;
  • 정승용 (도의대학교 식품영양학과)
  • Published : 1994.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was carried out to investigate the effect of the feeding mixture of linseed oil, rich in n-3 PUFA and the sunflower seed oil, rich in n-6 PUFA on the lipid metabolism in the dietary hyperlipidemic rats. After male Sprague-Dawley rats were induced hyperlipidemia by feeding the diet containing lard, butter and cholesterol for 3 weeks, then they were fed with the diet containing lard 3.0 % and butter 12.0% for control, the mixture in different proportion of both linseed oil and sunflower seed oil and antihyperlipidemic drugs for 2 weeks. Analysis of the lipid component of the serum showed following results. Concentration of total cholesterol in serum was significantly lower in the other groups except group 2 (lard 3.0 % + olive oil 12.0%) than in the control group , especially in groups 3 (cholestyramine 2.0%) and 5 (lard 3.0% + linseed oil 12.0%). HDL-C and the ratio of HDL-C to total cholesterol concentration were higher in groups 1, 3, 5 and 9 (lard 3.0% + sunflower seed oil 12.0%) , while the atherosclerotic index was low in groups3, 5. Concentrations of free cholesterol and choesteryl ester in serum were significantly lower in the other groups except group 2 than in the control group, especially lower in grop 5. Concentration of LDL was significantly higher in group 2 while it was remarkably lower in groups 3 and 5, while those of triglyceride in groups in 3 and 4 (lipraroid) were significantly higher than in the control groups. From the data on concentration of total choelsterol , HDL-cholesterol, LDL, phospholipid and triglyceride in serum, the results suggested that the feeding mixed with 3.0% lard and 12.0% linseed oil or 2.0% cholestyramine were most effective for the improvement of the serum lipids.

Keywords

References

  1. Lancet v.2 Dietary regulation of cholesterol metabolism Wood,P.D.S.;Shioda,R.;Kinsell,L.W.
  2. J. Clin. Invest. v.48 Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition Connor,W.E.;Witiak,D.T.;Stone,D.B.;Armstrong,M.L.
  3. Arch. Int. Med. v.105 Lowering of serum lipid concentrations Goldsmith,G.A.;Hamilton,J.G.;Miller,O.N.
  4. Lancet v.1 Effect of certain dietary oil on bile acid secretion and serum cholesterol Lewis,B.
  5. J. Clin. Invest. v.49 The effects of unsaturated dietary fats on absorption, excretion, synthesis and distribution of cholesterol in man Grundy,S.M.;Ahrens,E.H.
  6. J. Clin. Invest. v.44 Sterol balance in man as plasma cholesterol concentrations are altered by exchanges of dietary fats Spritz,N.;Ahrens,E.H.;Grundy,S.
  7. Am. J. Clin. Nutr. v.42 Why do polyun-saturated fatty acids lower serum cholesterol? Beynen,A.C.;Katan,M.B.
  8. Atherosclerosis v.20 Reduction of serum triglyceride levels by polyunsaturated fat Lewis,B.;Chait,A.;Onitiri,A.;Nicoll,A.;Robaya,E.
  9. Am. J. Clin. Nutr. v.34 The effect of low cholesterol, high polyunsaturated fat and low fat diets on plasma lipid and lipoprotein cholesterol levels in normal and hypercholesterolemic subjects Schaefer,E.J.;Levy,R.I.;Ernst,N.D.;Vansant,D.F.;Brewer,H.B.
  10. N. Engl. J. Med. v.290 Phospholipids in biology and medicine Jackson,R.L.;Gotto,A.M.
  11. Atherosclerosis v.49 Changes in very low density lipoproteins with diet fat modification Weisweiler,P.;Drosner,M.;Janetscheck,P.;Schwandt,P.
  12. Atherosclerosis v.20 Reduction of serum triglyceride levels by polyunsaturated fat Chait,A.;Onitiri,A.;Nicoll,A.;Rabaya,E.;Davies,J.;Lewis,B.
  13. 한국영양학회지 v.15 no.1 고불포화지방식이가 흰쥐의 plasma high density lipoprotein cholesterol량과 혈청 및 조직 내의 지방성분에 미치는 영향 박현서;최경희
  14. 한국영양식량학회지 v.15 no.1 식이지방의 P/S 비율이 흰쥐의 혈장 및 조직의 지질함량에 미치는 영향 김명희;임현숙;오승호
  15. Am. J. Clin. Nutr. v.30 Treatment of hypercholesterolemia Grundy,S.M.
  16. Atherosclersis v.41 Experimental atherosclerosis in rabbits fed cholesterol free diets Kritchevsky,K.;Tepper,S.A.;Bises,G.;Klurfeld,D.M.
  17. J. Lipid Res. v.21 Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man Shepherd,J.;Packard,C.J.;Grundy,S.M.;Yeshrun,D.;Gotto,A.;Taunton,O.D.
  18. Oil Chemistry v.30 no.10 Metabolism of the lipoproteins and lipids Itakura,H.
  19. J. Nutr. v.73 Effect of various oil and fats on serum cholesterol in experimental hypercholesterolemic rats Nicolaysen,R.;Regard,R.
  20. J. Nutr. v.119 The interrelated effects of n-6/n-3 and polyunsaturated/saturated ratios of dietary fats on the regulation of lipid metabolism in rats Lee,J.H.;Fukumoto,M.;Nishida,H.;Ikeda,I.;Sugano,M.
  21. Metabolism v.32 The comparative reduction of the plasma lipids and lipoproteins by dietary polyunsaturated fats Harris,W.S.;Connor,W.E.;McMurry,M.P.
  22. Jpn. J. Home Economic v.40 no.2 Changes of lipid metabolism in the plasma, liver, testes and epididymal adipose tissues of rats fed on oils being different in mixing proportion of corn oil and lard Takita,T.;Nakamura,K.;Suzuki,K.;Yamanash,N.;Innami,S.
  23. J. Jpn. Soc. Nutr. Food Sci. v.45 Effect of n-3/n-6 polyunsaturated fatty acid ratios on lipid metabolism in rats fed on hypercholesterolemic diets Takita,T.;Nakamura,K.;Suzuki,K.;Yamanashi,N.;Innami,S.
  24. 경상대학교 대학원 박사학위 청구논문 n-3 및 n-6계 다불포화 지방산의 함유 수준을 달리한 혼합유지의 급이가 흰쥐의 지질대사에 미치는 영향 김한수
  25. J. Lipid Res. v.10 The interaction of cholesterol absorption and cholesterol synthesis in man Grundy,S.M.;Davignon,J.
  26. Am. J. Clin. Nutr. v.44 Dietary and other correlates of changes in total and low density lipoprotein cholesterol in hypercholesterolemic men Glueck,C.J.;Gordon,D.J.;Nelson,J.J.;Davis,C.E.;Tyroler,H.A.
  27. Am. J. Physiol. v.250 Intestinal interaction of bile acids, phospholipid, dietary fibers and cholestyramine Gallaher,D.;Schneeman,B.O.
  28. J. Jpn. Soc. Nutr. Food Sci. v.42 Effect of different combinations of fish oil and corn oil in the diets on lipid metabolism in rats Takita,T.;Hayakawa,T.;Nakamura,K.;Fukutomi,A.;Innami,S.
  29. Am. J. Clin. Nutr. v.44 Controlled evaluation of fat intake in the Mediterranean diet Sirtori,C.R.;Tremoli,E.;Gatti,E.
  30. J. Jpn. Soc. Nutr. Food Sci. v.38 Effects of polyunsaturated fatty acid concentrates on lipids in the serum and liver of rats Kuroda,K.;Kobatake,Y.;Kubota,M.;Nishide,E.;Innami,S.
  31. 경상대학교 대학원 박사학위 청구논문 어유 및 종자유의 급이가 식이성 고중성지방혈증 흰쥐의 혈청, 뇌 및 간조직의 지질조성에 미치는 영향 정효숙
  32. J. Clin. Invest. v.59 no.14 Metabolism of cholesterol-rich chylomicrons Fielding,C.J.
  33. Biochem. Biophys. Acta v.531 The activity of an esterified cholesterol transferring factor in human and rat serum Barter,P.J.;Lally,J.I.
  34. Biochem. Biophys. Acta v.360 Regulation of cellular sterol flux and synthesis by human serum lipoproteins Bates,S.R.;Rothblat,G.H.
  35. 한국영양학회지 v.24 no.3 사람에서 식이지방의 불포화지방산과 불포화도가 혈장 지질조성에 미치는 영향 김채종;박현서
  36. J. Nutr. v.117 Lipoprotein lipase, lipoproteins and tissue lipids in rats fed fish oil or cocount oil Haug,A.;Hostmark,A.T.
  37. 검사 성적의 임상적 활용 김기홍(역편)
  38. Jpn. J. Nutr. v.45 no.6 Influence of phospholipid concentrates with different fatty acid patterns Kuroda,K.;Kobatake,Y.;Nishide,E.;Yamaguchi,M.
  39. Nutr. J. Sci. Vitaminol. v.29 Dietary effect of ω-3 type polyunsaturated fatty acid serum and liver level in rats Kobatake,Y.;Hiraha,F.;Innami,S.;Nishida,E.
  40. 日本營養食糧學會誌 v.41 no.4 高コレステロ-ル血症ラットの脂質代謝に及ぼすn-3, n-6およびn-9系各脂肪酸含有油脂投與の影響 鄭承鏞;瀧田聖親;中村カホル;早川享志;福富麻子;西卿光彦;印南敏
  41. J. Nutr. v.120 Effect of dietary fat source on lipoprotein composition and plasma lipid concentrations in pigs Faidley,T.D.;Luhman,C.M.;Galloway,S.T.;Foley,M.K.;Beitz,D.C.
  42. Semin. Thromb. Hemost. v.14 Effects of ω-3 fatty acids in hypertriglyceridemic states Connor,W.E.
  43. J. Clin. Invest. v.74 Suppression by diets rich in fish oil of very low density lipoprotein production in man Nestel,P.J.;Connor,W.E.;Reardon,M.F.;Connor,S.;Wong,S.;Boston,R.