The Effects of Dietary Protein and Caffeine Consumption Levels on Calcium Phosphorus, Sodium and Potassium Metabolism in the Rats of Different Ages

단백질과 카페인의 섭취수준이 나이가 다른 흰쥐의 칼슘, 인 , 나트륨 및 칼륨 대사에 미치는 영향

  • 여정숙 (숙명여자대학교 식품영양학과) ;
  • 승정자 (숙명여자대학교 식품영양학과)
  • Published : 1994.02.01


This study was designed to investigate the effects of dietary protein and caffeine consumption levels on Ca, P, Na and K metabolism. One hundred twenty rats were divided into twelve groups according to age, protein level and caffeine consumption such as group(120-130g young rat, 250-300g adult rat) , dietary protein group (20% normal protein , 85 low protein) , caffeine consumption group(0, 3.5mg, 7.0mg). Low protein diet containing high caffeine levels caffeine levels increased calcium, phosphorus, sodium and potassium contents of urine and fecal in rats. Young rat has higher level of calcium, phosphorus , sodium and potassium than adult rat. In the serum, calcium contents were not affected by age, dietary protein levels and caffeine consumption . However, phosphorus, sodium and potassium contents of serum in adult rat were higher than young rat. In the liver, potassium decreased with decreasing dietary protein levels. In the kidney, calcium , phosphorus and potassium contents were not different by age group, dietary protein levels and caffeine consumption , but sodium content was significantly reduced in the adult rat.



  1. 한국영양학회지 v.5 no.4 우리나라 식품소비 변화에 관한 고찰 채범석;신영무
  2. 도시가계연보 경제기획원 조사통계국
  3. 산업생산연보 경제기획원 조사통계국
  4. Nutrition update in caffeine and health Weininger,J.;Briggs,G.M.;Nightingale,S.L.;Flamn,W.G.
  5. Nutr. Rev. v.36 Caffeine-its identity, dietary sources, intake and biological effects Grahm,D.M.
  6. Central nervous system stimulants : The xanthines : The pharmacological basis of therapeutics(5th ed.) Ritchie,J.M.
  7. Clin. Pharmacol. Therap. v.11 Comparative stimulant and diuretic actions of caffeine and theobaomine in man Dorfman,L.J.;Jarvik,M.E.
  8. J. A. M. A. v.71 Physiologic and pyshchotropic effects of caffeine on man Stephenson,P.E.
  9. J. Food Safety v.4 The pharmacology and toxicology of caffeine Lachance,M.P.
  10. Pharmacol. Rev. v.14 Enhancement of human performance by caffeine and the amphetamins Weiss,B.;Laties,V.G.
  11. Psychopharmacology v.40 The effects of age and illumination on the dose-response curres for three stimulants Kallman,W.M.;Issacs,W.
  12. Fed. Proc. v.33 Spontaneous locomotor activity charges evoked by caffeine in mice Hirsh,K.R.;Pinzone,M.G.;Forde,J.H.
  13. Drill's pharmacology in medicine(4th ed.) The xanthines Truitl,E.B.
  14. Am. J. Clin. Nutr. v.33 Caffeine and coffee-their influence on metabolic rate substrate utilization in normal weight and obese individuals Acheson,K.J.;Markiewicz,B.Z.;Anantharaman,K.;Jequier,E.
  15. Arch. Intern. Med. v.19 The effect of caffeine heart production Means,J.H.;Aub,J.C.;Dubois,E.F.
  16. Am. J. Clin. Nutr. v.34 A simple apparatus for comparative measurements of energy expenditure in human subjects : The thermic effect of caffeine Hollands,M.A.;Arch,J.R.S.;Cawthorne,M.A.
  17. N. Engl. J. Med. v.298 Effect of caffeine on plasma renin activity, catecholamines and blood pressure Robertson,D.;Frolich,J.C.;Carr,R.K.;Watson,J.T.;Hollifield,J.W.;Shand,D.G.;Oates,J.A.
  18. J. Clin. Invest. v.16 A clinical study of the action of 10 commonly used drugs on cardiac output, work and size, on respiration on metabolic rate and on the electrocardiogram Stars,I.
  19. Am. J. Med. v.73 Effect of coffe and cigarette smoking on the blood pressure on untreated and diuretic-treated hypertensive patients Freestone,S.;Ramsay,L.E.
  20. Am. J. Cardiol. v.56 Circulatory effects of coffee in relation to the pharmacokinetics of caffeine Smits,P.;Thien,T.;Larr,A.
  21. Fed. Proc. v.40 Effect of acute oral caffeine treatment on spleen and thymus of male rats Ross,V.C.;Friedman,L.;Gaines,D.W.;Keys,J.E.
  22. Am. J. Physiol. v.141 The effect of caffeine upon gastric secretion in the dog, cat and man Roth,J.A.;Ivy,A.C.
  23. J. A. M. A. v.126 Caffeine and peptic ulcer Roth,J.A.;Ivy,A.C.;Atkinson,A.
  24. Scand. J. Gastroenterol. v.6 Caffeine-stimulated acid and pepsin secretion : Dose-response studies Debas,H.T.;Cohen,M.M.;Holubitsky,I.B.;Harrison,R.C.
  25. Can. J. Physiol. Pharmacol. v.43 The chronic oral toxicity of caffeine Boyd,E.;Dolman,M.;Knight,L.;Scheppard,E.
  26. J. Nutr. v.116 Influence of injected caffeine on the metabolism of calcium and the retention and excretion of sodium, phosphorus, magnesium, zinc and copper in rats Yeh,J.K.;Aloia,J.F.;Semla,H.M.;Chen,S.Y.
  27. Nutr. Res. v.8 Acute effects of dietary caffeine and sucrose on urinary mineral excretion of healthy adolescents Massey,L.K.;Hollingbery,P.W.
  28. Nutr. Res. v.4 The effect of dietary caffeine on urinary excretion of calcium, magnesium, sodium and potassium in health young females Massey,L.K.;Wise,K.L.
  29. J. Nutr. v.117 Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat Whiting,S.J.;Whitney,H.L.
  30. Am. J. Clin. Nutr. v.42 The relationship between diet and bone mineral content of multiple skeletal sites in elderly japaneses-American men and women living in Hawaii Yano,K.;Heilbrun,L.K.;Wasnich,R.D.;Hankin,J.H.;Vogel,J.M.
  31. J. Nutr. v.116 Coffee intake during pregnancy and lactation in rats : Maternal and pup hematological parameters and liver iron, zinc and copper concentration Munoz,L.;Keen,C.L.;Lonnerdal,B.;Dewey,K.
  32. Clin. Res. v.25 Maturation of caffeine desposition in infancy Aranda,J.V.;Collinge,J.M.;Zimman,R.;Trippenback,T.;Jain,R.
  33. Clin. Pharmacol. Ther. v.25 Caffeine metabolism in the newborn Aldrige,A.;Aranda,J.V.;Neins,A.H.
  34. J. Am Dietet. Assoc. v.86 Beverages in the diets of American teenagers Guenther,P.M.
  35. J. Nutr. v.107 American Institute of Nutrition : Report of the American Institute of Nutrition : Ad Hoc committee on Standards for nutritional studies
  36. 식품분석 신효선
  37. J. Biol. Chem. v.158 On the calorimetric determination of creatinine by the Jaffe reaction Bonsnes,R.W.;Taussky,H.H.
  38. 식품과 영양 v.17 no.1 식품의 무기성분 분석 임정남
  39. Br. J. Nutr. v.39 The hypercholesterolemic effect of caffeine in rats fed on diets with and without supplementary cholesterol Fears,R.
  40. J. Pharmacol. Exptl. Therap. v.22 Drugs and basal metabolism Boothby,W.M.;Rowntree,L.G.
  41. 서울여자대학교대학원 석사학위논문 Coffee의 첨가가 흰쥐의 HDL-cholesterol 및 체내 지방대사에 미치는 영향 김미자
  42. J. Nutr. v.97 Influence of caffeine containing beverages on the growth, food utilization and plasma lipids of the rat Naismith,D.J.;Akinjanju,P.A.;Yudkin,J.
  43. 영남대학교대학원 석사학위논문 Caffeine첨가 사료가 백쥐의 혈청 및 간장성분에 미치는 영향 안태영
  44. 성신여자대학교대학원 석사학위논문 지방 수준을 달리한 식이에 카페인의 첨가가 흰쥐의 체내 지방대사에 미치는 영향 배현숙
  45. 이화여자대학교대학원 석사학위논문 단백질의 종류를 달리한 식이에 첨가한 coffee와 methionine이 흰쥐의 단백질과 지방대사에 미치는 영향 김영심
  46. Nutr. Res. v.5 Effect of dietary caffeine on urinary excretion of calcium, magnesium, phosphorus, sodium, potassium, chloride and zinc in healthy males Massey,L.K.;Berg,T.A.
  47. J. Nutr. v.110 Studies on the mechanism of protein-induced hypercalciuria in older men and women Schuette,S.A.;Zemel,M.B.;Linkswiler,H.M.
  48. J. Nutr. v.110 The role of sulfate in the calciuria of high protein diets in adult rats Whiting,S.J.;Draper,H.H.
  49. 한국영양학회지 v.19 no.1 단백질 종류가 체내 칼슘대사에 미치는 영향에 관한 연구 피재은;백희영
  50. 이화여자대학교대학원 석사학위논문 Coffee를 지방의 수준과 종류를 달리한 식이에 첨가 하였을때 흰쥐의 지방대사에 미치는 영향 정조인
  51. J. Lab. Clin. Med. v.99 Effects of nitrogen, phosphorus and caffeine on calcium balance in women Heaney,R.;Recker,R.R.
  52. Modern nutrition in health and disease(6th ed.) Avioli,L.V.
  53. Modern nutrition in health and disease(6th ed.) Li,T.K.;Vallee,B.L.
  54. Modern nutrition in health and disease(6th ed.) Water, electrolytes and acid-base balance Randall,H.T.
  55. Toxicol. Lett. v.7 Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man Latini,R.;Bonati,M.;Marzi,E.;Garattini,S.
  56. J. Nutr. v.104 Effect of protein intake on calcium balance of young men given 500mg calcium daily Anand,C.R.;Linkswiller,H.M.
  57. Am. J. Clin. Nutr. v.31 Effect of a high protein(meat) intake on calcium metabolism in man Spencer,H.;Kramer,L.;Osis,D.;Norris,C.
  58. 숙명여자대학교대학원 박사학위논문 단백질 섭취수준이 인체내 칼슘, 인, 마그네슘 대사에 미치는 영향에 관한 연구 김순경
  59. J. Nutr. v.105 Effect of a high protein intake on calcium metabolism in rat Bell,R.R.;Engelmann,D.T.;Sie,T.;Draper,H.H.
  60. Am. J. Clin. Nutr. v.27 Studies in calcium metabolism : The calciuretic effect of dietary protein Margen,S.;Chu,J.Y.;Kaufman,N.A.;Callaway,D.H.
  61. 상명여자사범대학대학원 석사학위논문 고 지방식이에 첨가한 Caffeine 음료가 흰쥐의 체내 지방대사에 미치는 영향 이경숙
  62. 성심여자대학교대학원 석사학위논문 단백질 급원과 식이내 Mg 함량이 흰쥐의 체내 Ca 및 Mg, P 대사에 미치는 영항 조미혜