• Journal of Haehwa Medicine
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• v.14 no.2
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• pp.71-85
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• 2005

As a long-term goal for the development of new prescriptions for hyperlipidemia, IJWRT was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. IJWRT didn't show the cytotoxicity on Human Fibroblast Cells(hFCs). The body weight of hyperlipidemia-induced rats began to show lower body weight beginning one week after IJWRT treatment compared to non-treated control group animals. Cholesterol levels showed a significant decrease beginning three weeks after IJWRT treatment, compared to hyperlipidemia-induced control group. Total cholesterol levels in IJWRT treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. Glucose levels in IJWRT treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. Triglyceride levels in IJWRT treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. SGOT levels in IJWRT treated animal group were insignificantly decreased compared to the hyperlipidemia-induced control group whereas there was significant change in SGPT levels. HDL-cholesterol levels were significantly increased in IJWRT treated animal group compared to the hyperlipidemia-induced control group. LDL-cholesterol levels were significantly decreased in IJWRT treated animal group compared to the hyperlipidemia-induced control group.

• The Korea Journal of Herbology
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• v.32 no.3
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• pp.9-17
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• 2017

Objectives : Kyeongok-go has the effect of antioxidant, anti-cancer, improving fatigue, and hyperlipidemia, but it is not easy to use in clinical practice becausee of the complicated manufacturing process of heat control and moisture control. The aim of this study was to explore the lipid improvement effect of new manufacturing methods prodeced Kyeongok-go in hyperlipidemia rats. Methods : The SD rats were divided randomly into 8 groups of six animals each : Normal rats (Nor), hyperlipidemia rats (Con), hyperlipidemia rats treated with Spirulina 60 mg/kg(SP60), hyperlipidemia rats treated with Commercial Kyeongok-go 1 g/kg (K0), hyperlipidemia rats treated with Kyeongok-go manufactured by heating mantle 1 g/kg (K1), hyperlipidemia rats treated with ginseng fermentation Kyeongok-go 1 g/kg (KF), hyperlipidemia rats treated with Kyeongok-go with black ginseng 1 g/kg (BK), hyperlipidemia rats treated with black ginseng fermentation Kyeongok-go 1 g/kg (BKF). The experimental group induced hyperlipidemia by eating high cholesterol diet for 8 weeks. Also, we compared Kyeongok-go manufacturing method using the new method compared with traditional method. Results : As a result, the improvement effect of hyperlipemia using the new method showed the similar or better improvement effect compared with the conventional method, and it is considered that the Kyeongok-go manufacturing method using the new method can be substituted for the traditional Kyeongok-go manufacturing method. Conclusion : In conclusion, these results suggest that new manufacturing methods prodeced Kyeongok-go has the potential as a anti-hyperlipidemia material which possess lipid improvement activities.

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.97-107
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• 2004

As a long-term goal for the development of new prescriptions for hyperlipidemia, SGHHT was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. The body weight of hyperlipidemia-induced rats began to show lower body weight beginning one week after SGHHT treatment compared to non-treated control group animals. 2. Cholesterol levels showed a significant decrease beginning three weeks after SGHHT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group.6. SGOT levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group whereas there was no significant change in SGPT levels. 7. HDL-cholesterol levels were significantly increased in SGHHT- treated animal group compared to the hyperlipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in SGHHT-treated animal group compared to the hyperlidemia-induced control group.

• CELLMED
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• v.14 no.3
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• pp.69.1-69.3
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• 2024

Objective: A Case of improvement of hyperlipidemia through the use of OCNT. Methods: A Korean female in her 40s has been suffering from a wide range of symptoms due to hyperlipidemia. Results: Hyperlipidemia was improved following implementation of OCNT. Conclusion: Application of OCNT on hyperlipidemia can be helpful in alleviation of symptoms.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1138-1142
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• 2002

Dansamchunghyul-tang(丹參淸血湯) is a new formula consist of Salviae Miltiorrhizae Radix and some oriental herbs to treatment of hyperlipidemia. In this study, we investigated the effects of the water extract of Dansamchunghyul-tang(DCT) on hyperlipidemia of the rat. We here studied the influence of DCT on hyperlipidemia in Sprague-Dawley rats. The hyperlipidemia was induced by Triton WR-1339 (tyloxapol) intravenous injection at 200mg/kg body weight. After 18 h, blood was collected for the determination of plasma total cholesterol, triglyceride, phospholipid, HDL-cholesterol, and LDL-cholesterol concentrations. In the model of hyperlipidemia induced by triton WR-1339 in rats, DCT showed decreasing effects on total cholesterol, triglyceride, phospholipid level significantly, in a dose-dependent fashion. DCT showed dose-dependent effects on HDL-cholesterol and LDL-cholesterol level insignificantly. In conclusion, DCT showed significant effects on hyperlipidemia, and the present findings indicate that DCT may prove potentially useful for treatment of hyperlipidemia.

• The Journal of Internal Korean Medicine
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• v.29 no.3
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• pp.703-715
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• 2008

This experiments was performed to determine the effects of Gangzitongmaekeum(降脂通脈飮 : GTE) on antioxidation activity and hyperlipidemia induced by hypercholesterolemic diet in mice. The results obtained were as follows : 1. GTE showed a safety in cytotoxicity and toxicity of human fibroblast cells and liver. 2. GTE showed DPPH scavenging activity, superoxide dismutase (SOD)-like activity and inhibitory effect on reactive oxygen species (ROS). 3. GTE treated mice showed body and liver weight decrease, compared to the hyperlipidemia-induced control group. 4. GTE decreased total cholesterol and LDL cholesterol levels significantly, but HDL cholesterol levels not significantly. 5. GTE decreased triglyceride levels significantly. 6. Glucose levels in GTE treated mice significantly decreased compared to the hyperlipidemia-induced control group. 7. Albumin levels in GTE treated mice were similar with the hyperlipidemia-induced control group. 8. The lipophagy in liver compared with the control group tended to be decreased in GTE treated mice. In the change of aorta, the cell was regular and boundary of vessel wall was clear, compared to the hyperlipidemia-induced control group. 9. TBARS levels in GTE treated mice significantly decreased compared to the hyperlipidemia-induced control group. 10. The change of SOD and catalase activity significantly increased compared to the hyperlipidemia-induced control group. 11. ACAT mRNA level and HMG-CoA reductase mRNA levels in GTE treated mice significantly decreased compared to the hyperlipidemia-induced control group. Conclusion : These results suggest that Gangzitongmaekeum is effective in antioxidation activity and dietary hyperlipidemia-induced mice.

• Physical Therapy Rehabilitation Science
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• v.7 no.2
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• pp.88-93
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• 2018

Objective: Elevated cholesterol levels contribute to changes of the arterial endothelial permeability. Hyperlipidemia promotes atherosclerosis and is associated with an increased risk of stroke incidence. The purpose of this study was to investigate the effects of having a history of hyperlipidemia prior to a stroke incidence on postural balance, anticipatory dynamic postural control, gait endurance and gait performance in individuals with hemiparetic stroke. Design: Cross-sectional study. Methods: Fifty-two adults who were diagnosed with stroke 6 months ago or more were enrolled in this study. They were divided into two different groups according to hyperlipidemia history before stroke. All participants were assessed with the Activities-specific into Balance Confidence (ABC) scale, Berg Balance scale (BBS), Dynamic Gait Index (DGI), Timed Up and Go test (TUG), and the 6-minute walk test (6MWT). An independent t-test was used to analyze the difference between the hyperlipidemia group and non-hyperlipidemia group. Results: After analysis, the BBS, TUG, and 6MWT scores were significantly different between the hyperlipidemia and non-hyperlipidemia group, but not the ABC and DGI scores. Conclusions: The results of this study show that having a history of hyperlipidemia before stroke affects static and dynamic postural balance performance, anticipatory dynamic postural balance, and gait endurance in individuals with chronic hemiparetic stroke. Based on the results of this study, we also suggest treatment for hyperlipidemia should be implemented throughout the therapeutic interventions, such as pharmacological or exercise programs, in order to restore the physical function of stroke survivors.

• Journal of Society of Preventive Korean Medicine
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• v.6 no.2
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• pp.95-103
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• 2002

In order to study the effect of Luffae fasciculus vascularis(絲瓜絡) on hyperlipidemia, experimental study was performed on Hyperlipidemia induced by Triton WR-1339. Also the level of Total cholesterol, Triglyceride, HDL-cholesterol, Phospholipid and LDL-cholesterol were measured. The results are summarized as follow: In the model of hyperlipidemia Rats induced by Triton WR-1339, luffae fasciculus vascularis(絲瓜絡) had significantly decreasing effects on total cholesterol, triglyceride, phospholipid, LDL-cholesterol in serum and increasing effects on HDL-cholesterol level in serum but were not significant. These results show that Luffae fasciculus vascularis(絲瓜絡) has significantly inhibitory effects on hyperlipidemia and that it could be clinically applied for hyperlipidemia.

• CELLMED
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• v.13 no.9
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• pp.33.1-33.4
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• 2023

Objective: A case report on the Improvement of Hyperlipidemia Patients Using Ortho-Cellular Nutrition Therapy (OCNT). Methods: A Korean woman in her 50s was diagnosed with hyperlipidemia, and she has had a very high level of LDL-cholesterol. Results: After performing OCNT, the LDL-cholesterol level decreased from 208 mg/dL to 109 mg/dL. Conclusion: The application of OCNT to patients with hyperlipidemia can help reduce their LDL-cholesterol levels and relieve symptoms.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.9-14
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• 2010

The purpose of this study was to review the direction of Korean medicine treatment in hyperlipidemia, focusing on Korean herbal medicine and to suggest sources for drug development in treatment of hyperlipidemia. We searched 115 articles which had been published from 1997 to 2009 in journals in Korean Oriental Medical Society and its sub-societies. Those articles were selected from the search engine of web site of each journal with the key words 'hyperlipidemia'. Excluding 21 articles in no relation to herbs, we finally reviewed 94 articles. There are many studies of 'hyperlipidemia' in Korean Medicine. Analyzing the articles, we found that the medicinal effects of the herbs used in recent studies and patents coincides with treatment of hyperlipidemia in Korean medicine. Although many herbs in articles is granted patent, it doesn't proceeds to develop herbal drug. It requires to study in treatment of hyperlipidemia in Korean medicine and then to develop herbal drug.