Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)

The Korean Society of Animal Reproduction (한국동물번식학회)
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Biological Activities of Tethered Equine Chorionic Gonadotropin (eCG) and Its Deglycosylated Mutants

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  • N.P JarGil ;
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  • 김민수 (한경대학교 생물정보통신전문대학원 동물생명공학과) ;
  • 박종주 (한경대학교 생물정보통신전문대학원 동물생명공학) ;
  • 정윤희 (한경대학교 생물정보통신전문대학원 동물생명공학) ;
  • 이유연 (한경대학교 생물정보통신전문대학원 동물생명공학) ;
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  • 윤종택 (동물생명자원학) ;
  • 민관식 (한경대학교 생물정보통신전문대학원 동물생명공학과)
  • Published : 2004.06.01
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Abstract

Equine chorionic gonadotropin (eCG), which consists of highly glycosylated α- and β-subunits, is a unique member of the gonadotropin family because it elicits response characteristics of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in other species than the horse. To determine whether α and β subunits can be synthesized as a single polypeptide chain (tethered-eCG) and also display biological activity, the tethered-eCG molecule was constructed and transfected into Chinese hamster ovary (CHO-K1) cells. (omitted)

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