Production of Human Keratinocyte 14 Promoter Driven EC-SOD Transgenic Mice

  • Kim, Sung-Hyun (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College, Department of Animal Science, Graduate School of Konkuk University) ;
  • Lee, Tae-Hoon (Laboratory of Oral Biochemistry, College of Dentistry, Chonnam National University) ;
  • Kim, Kil-Soo (Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Eun-Ju (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
  • Kim, Myoung-Ok (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
  • Park, Jun-Hong (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
  • Cho, Kyoung-In (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
  • Jung, Boo-Kyung (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
  • Kim, Hee-Chul (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
  • Hwang, Sol-Ha (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
  • Lee, Hoon-Taek (Department of Animal Science, Graduate School of Konkuk University) ;
  • Ryoo, Zae-Young (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College)
  • Published : 2004.06.01

Abstract

Superoxide dismutases are key antioxidant enzymes in metabolism of reactive oxygen species. Three different isoforms of SOD exist in mammals. The extracellular SOD (EC-SOD) is the most recently discovered SOD family member. This isoform is a copper- and zinc-containing enzyme like Cu/Zn-SOD and a homotetrameric glycoprotein with a molecular weight of about 165 kDa in mouse. (omitted)

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