Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.175.4-176
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- 2003
Wogonin and Its Analogs
- Jang, Jin-Hee (College of Pharmacy, Kangwon National University) ;
- Sin, Kwan-Seog (College of Pharmacy, Kangwon National University) ;
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Park, Hae-Il
(College of Pharmacy, Kangwon National University)
- Published : 2003.10.01
Abstract
Our long-term research goals involve the SARs study and the synthetic procedure development of wogonin and its analogs. We investigated efficient synthetic pathways of wogonin and its bioisosteres in a large quantity to decipher the structural requirements for anti-inflammatory activities. We plan to serially delete or modify the 5,7-dihydroxyl groups of wogonin to observe the effects of the hydroxyl groups on anti-inflammatory activity. Also we modofied the 8- methoxy group on a ring since it is known to be necessary for biological activity. (omitted)
Keywords