Proceedings of the PSK Conference (대한약학회:학술대회논문집)
The Pharmaceutical Society of Korea
- 기타
Domain
- Health Sciences > Development of Pharmaceutical
2005.11a
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Yeo, Marie;Kim, Dong-Kyu;Park, Hee-Jin;Oh, Tae-Young;Kim, Jang-Hee;Lee, Jeong-Sang;Surh, Young-Joon;Hahm, Ki-Baik 126
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Dulak, Jozef;Jozkowicz, Alicja;Golab, Jakub;Was, Halina;Nowis, Dominika;Stoklosa, Tomasz;Loboda, Agnieszka;Jazwa, Agnieszka 131
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Jeon, Eun-Joo;Lee, Kwang-Youl;Choi, Nam-Sook;Lee, Mi-Hye;Kim, Hyun-Nam;Jin, Yun-Hye;Ryoo, Hyun-Mo;Choi, Je-Yong;Bae, Suk-Chul 219
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Bacteria of Shigella spp. are responsible for shigellosis in humans, a disease characterized by destruction of the colonic epithelium that is induced by the inflammatory response elicited by invasive bacteria. They use a type III secretion system injecting effector proteins into host cells to induce their entry into epithelial cells and triggers apoptosis in macrophages. We present evidence that the effector OspG is a protein kinase that binds various ubiquitinylated ubiquitin-conjugating enzymes (E2s) and blocks degradation of phospho-
$I{\kappa}B{\alpha}$ induced upon entry of bacteria into epithelial cells. Transfection experiments confirmed that OspG interferes with the$NF-{\kappa}B$ activation patway by preventing phospho-$I{\kappa}B{\alpha}$ degradation, suggesting that OspG inactivates a component of the$SCF^{{\beta}-TrCP}$ ubiquitin ligase complex (E3) involved in phospho-$I{\kappa}B{\alpha}$ ubiquitination. Upon infection of ileal loops in rabbits, the ospG mutant induced a stronger inflammatory response compared with the wild-type strain, indicating that OspG down-regulates the host innate response induced by invasive bacteria. -
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