Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.176.1-176.1
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- 2003
Developing a pharmacophore model for nonpeptide bradykinin antagonists
- Park, Hae-Young (Ewha Womans University) ;
- Choi, Su-Young (KIST) ;
- Lee, Su-Jin (Biochemical Reserch Center) ;
- Koh, Hune-Yeong (Biochemical Reserch Center) ;
- Pae, Ae-Nim (Biochemical Reserch Center)
- Published : 2003.10.01
Abstract
Bradykinin is an autocoid related to acute and chronic pain and inflammation. The non-peptide bradykinin antagonists are of interest as novel anti-inflammatory therapeutics. To understand the structural basis for the bradykinin antagonistic activity and to guide the design of more potent compounds we analysed the three dimensional pharmacophore model. Seven active compounds very recently reported such as FR 167344, FR 173657, LF 160687, and bradyzide were used as our pharmacophore model analysis. (omitted)
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