Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.175.3-175.3
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- 2003
Synthesis of 2-phenyl-1,8-naphthyridin-4-ones
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Im, Cha-Euk
(Chung-ang University, College of Pharmacy)
;
- Park, Sang-Min (Chung-ang University, College of Pharmacy) ;
- Kim, Yong-Hyun (Chung-ang University, College of Pharmacy) ;
- Chung, Mi-Ryang (Chung-ang University, College of Pharmacy) ;
- Yim, Chul-Bu (Chung-ang University, College of Pharmacy)
- Published : 2003.10.01
Abstract
2-Phenyl-1, 8-naphthyridin-4-ones had been synthesized for their cytotoxic activity. Substituted acetophenone was treated with NaH and diethyl carbonate to give ethyl benzoylacetates, which was reacted with substituted 2-aminopyridine and PPA to yield 2-phenylpyridopyrimidine-4-ones. These compounds was heated at
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