• Genomics & Informatics
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• v.11 no.1
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• pp.46-51
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• 2013

Normal-karyotype acute myeloid leukemia (NK-AML) is a highly malignant and cytogenetically heterogeneous hematologic cancer. We searched for somatic mutations from 10 pairs of tumor and normal cells by using a highly efficient and reliable analysis workflow for whole-exome sequencing data and performed association tests between the NK-AML and somatic mutations. We identified 21 nonsynonymous single nucleotide variants (SNVs) located in a coding region of 18 genes. Among them, the SNVs of three leukemia-related genes (MUC4, CNTNAP2, and GNAS) reported in previous studies were replicated in this study. We conducted stepwise genetic risk score (GRS) models composed of the NK-AML susceptible variants and evaluated the prediction accuracy of each GRS model by computing the area under the receiver operating characteristic curve (AUC). The GRS model that was composed of five SNVs (rs75156964, rs56213454, rs6604516, rs10888338, and rs2443878) showed 100% prediction accuracy, and the combined effect of the three reported genes was validated in the current study (AUC, 0.98; 95% confidence interval, 0.92 to 1.00). Further study with large sample sizes is warranted to validate the combined effect of these somatic point mutations, and the discovery of novel markers may provide an opportunity to develop novel diagnostic and therapeutic targets for NK-AML.

• 한국공간정보시스템학회:학술대회논문집
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• 1999.06a
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• pp.193-200
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• 1999

The major purpose of this study was to design a external metadata which fit domestic demands of the digital maps. For designing a standard external metadata reflecting the current trends of the international organizations on standardization, a prelimenary study was made mainly concentrating on the analysis of the standards of the developed countries. For better assessing domestic needs, all the metadata related material of the National Geography Institute were collected and classified based on the NGI's workflow. The external metadata draft was made considering the results from the analysis of the existing NGI material and the draft was also cited some major cores from the ISO standards. Continuous efforts should be made in the future to update the metadata draft based on the opinions from domestic users and the technical trends of the international organizations on standardization.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.78-78
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• 2006

Gene expression analysis can be performed by one-color (intensity-based) or two-color (ratio-based) microarray platforms depending on the specific applications and needs of the researcher. The traditional two-color approach is well founded from a historical and scientific standpoint, and the one-color approach, when paired with high quality microarrays and a robust workflow, offers additional flexibility in experimental design. Two of the major requirements of any microarray platform are system reproducibility, which provides the means for high confidence experiments and accurate comparison across multiple samples; and high sensitivity, for the detection of significant gene expression changes, including small fold changes across multiple gene sets. Each of these requirements is fulfilled by the Agilent One-color Gene Expression Platform as illustrated by the data included in this study. As a result, researchers have the ability to take advantage of the enhanced performance and sensitivity of Agilent's 60-mer oligonucleotide microarrays, and experience the first commercial microarray platform compatible with both one- and two-color detection.

• Journal of Information Technology Services
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• v.20 no.4
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• pp.113-128
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• 2021

In the rapidly developing 4th industrial revolution. RPA is increasing in use at home and abroad due to its advantages of simplifying workflow and providing flexibility and scalability at the same time. Thus, this paper conducted an empirical study on companies using RPA to determine which factors affect the intention to use the services provided by RPA systems. As system characteristics, exogenous variables were selected as information quality, system quality, and service quality of the information system success model. The endogenous variables were selected as the system acceptance factors for the performance and effort expectancy of the integrated technology acceptance model, and the perceived economic values and functional values were additionally selected. For the purpose of this study, a structured questionnaire was used for empirical analysis and the proposed hypothesis was verified through the path analysis of structural equations. As a result of the study, there was no significant relationship between service quality and effort expectancy, between service quality and economic value, and it was verified that the relationship between other factors was positively significant.

• The Journal of the Korean dental association
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• v.57 no.2
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• pp.100-104
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• 2019

Orthognathic surgery is designed to correct problems of the jaw and face and restore facial harmony. The limitations of orthognathic surgery occur at all steps of the surgical workflow: preoperative planning, simulation, and operation. Many studies have shown the accuracy and advantages of 3 dimensional computer-assisted program for orthognathic surgery. The purpose of this paper is to introduce the accuracy of the maxillary repositioning in patients who underwent orthognathic surgery using a 3 dimensional computer assisted surgery program. The reliability of computer guided orthognathic surgery using splint and surgical guide need to be improved further. The 3 dimensional computer assisted analysis seems to be more precise to interpret than two-dimensional analysis. High-precision planning of orthognathic surgery has predictable results. Three-dimensional computer assisted orthognathic surgery has the following advantages : planned surgical movement is possible, splints guide with CAD/CAM technology; and increase predictable results .Computer assisted simulation surgery ensures accuracy during surgery, thereby facilitating predictable results. It may provide solution that enables surgeon to perform planned surgery more accurately.

• Geomechanics and Engineering
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• v.24 no.3
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• pp.281-293
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• 2021

Uncertainties in geomechanical input parameters which mainly related to inappropriate data acquisition and estimation due to lack of sufficient calibration information, have led wellbore instability not yet to be fully understood or addressed. This paper demonstrates a workflow of employing Quantitative Risk Assessment technique, considering these uncertainties in terms of rock properties, pore pressure and in-situ stresses to makes it possible to survey not just the likelihood of accomplishing a desired level of wellbore stability at a specific mud pressure, but also the influence of the uncertainty in each input parameter on the wellbore stability. This probabilistic methodology in conjunction with Monte Carlo numerical modeling techniques was applied to a case study of a well. The response surfaces analysis provides a measure of the effects of uncertainties in each input parameter on the predicted mud pressure from three widely used failure criteria, thereby provides a key measurement for data acquisition in the future wells to reduce the uncertainty. The results pointed out that the mud pressure is tremendously sensitive to UCS and SHmax which emphasize the significance of reliable determinations of these two parameters for safe drilling. On the other hand, the predicted safe mud window from Mogi-Coulomb is the widest while the Hoek-Brown is the narrowest and comparing the anticipated collapse failures from the failure criteria and breakouts observations from caliper data, indicates that Hoek-Brown overestimate the minimum mud weight to avoid breakouts while Mogi-Coulomb criterion give better forecast according to real observations.

• Journal of KIISE:Software and Applications
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• v.31 no.10
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• pp.1276-1285
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• 2004

A web-based model for implementation of mobile compliance analysis system for software contents is proposed. It is said that the content is compliant if the content can be executed properly in mobile environment. The mobile compliance analysis of contents is very important because contents can't be serviced if they arc not proper for mobile environment. The categories of mobile compliance analysis for software contents are proposed. The model of this paper uses the Factory Method pattern and the Facade pattern. The workflow of the s${\gamma}$stem is described through collaborations of classes in the model. As a case study, core Java APIs for implementation of the model arc represented and the mobile compliance analysis system for HDML contents has been built. The model is flexible so that it is easy to add new modules or remove some modules for contents analysis. Although the model is based on the JSP and Java beans, it can be expanded to support any other programming technique such as EJB.

• Journal of Crop Science and Biotechnology
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• v.11 no.2
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• pp.91-100
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• 2008

Melting curve analysis of fluorescently labeled DNA fragments is used extensively for genotyping single nucleotide polymorphism(SNP). Here, we evaluated a SNP genotyping method by melting curve analysis with the two probe chemistries in a 384-well plate format on a Roche LightCycler 480. The HybProbe chemistry is based on the fluorescence resonance energy transfer(FRET) and the SimpleProbe chemistry uses a terminal self-quenching fluorophore. We evaluated FRET HybProbes and SimpleProbes for two SNP sites closely linked to two quantitative trait loci(QTL) for southern root-knot nematode resistance. These probes were used to genotype the two parents and 94 $F_2$ plants from the cross of PI 96354$\times$Bossier. The SNP genotypes of all samples determined by the LightCycler software agreed with previously determined SSR genotypes and the SNP genotypes determined on a Luminex 100 flow cytometry instrument. Multiplexed HybProbes for the two SNPs showed a 98.4% success rate and 100% concordance between repeats two of the same 96 DNA samples. Also, we developed a HybProbe assay for the Rcs3 gene conditioning broad resistance to the frogeye leaf spot(FLS) disease. The LightCycler 480 provides rapid PCR on 384-well plate and allows simultaneous amplification and analysis in approximately 2 hours without any additional steps after amplification. This allowed for a reduction of the potential contamination of PCR products, simplicity, and enablement of a streamlined workflow. The melting curve analysis on the LightCycler 480 provided high-throughput and rapid SNP genotyping and appears highly effective for marker-assisted selection in soybean.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.36 no.4
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• pp.259-264
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• 2023

In this study, we devised a parametric analysis workflow for efficiently analyzing the material properties of 3D woven materials. The parametric model uses wire spacing in the woven materials as a design parameter; we generated 2,500 numerical models with various combinations of these design parameters. Using MATLAB and ANSYS software, we obtained various material properties, such as bulk modulus, thermal conductivity, and fluid permeability of the woven materials, through a parametric batch analysis. We then used this large dataset of material properties to perform a regression analysis to validate the relationship between design variables and material properties, as well as the accuracy of numerical analysis. Furthermore, we constructed an artificial neural network capable of predicting the material properties of 3D woven materials on the basis of the obtained material database. The trained network can accurately estimate the material properties of the woven materials with arbitrary design parameters, without the need for numerical analyses.

• Journal of Digital Convergence
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• v.15 no.8
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• pp.145-160
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• 2017

This paper aims to investigate the effects of Smart-Work IT resources on job performance. The survey was conducted amongst the business workers who are currently engaged in domestic major companies as well as small businesses, and analyzed based on the frequency, factor and reliability. Using PROCESS Macro, we conducted an analysis of the relationship between the IT resources and job performance, treating collective intelligence as a mediating parameter. The results of the study are as follows. First, the IT resources of the companies were found to have a meaningful effect on job performance. Second, the IT resources were found to have no effect on employee productivity except through their effect on the collective intelligence. Finally, while openness and cooperation were found to be the aspects of collective intelligence which mediated between IT resources and workflow improvement, participation, openness and cooperation were found to be the aspects of collective intelligence which mediated between IT resources and workflow coordination, In the future, it is necessary to compare quantitatively the financial performance of Smart-Work adopters and others in the same industry or to compare the financial performance before and after introducing Smart-Work dynamically within the same company.