• Bulletin of the Korean Chemical Society
• /
• 제29권5호
• /
• pp.959-962
• /
• 2008

We have performed FlexX docking experiments to predict the best docking poses of 5-androst-16-en-3-ol or 5-androst-16-en-3-one to Boar salivary lipocalin (SAL). Since no steroids were found inside of the binding pocket of the X-ray structure of 1GM6, we tried to find docking structures after opening the pocket using the random tweak option implemented in SYBYL. This operation allowed the ligand to enter the pocket. The best poses generated from FlexX were different from the structures reported earlier, which calculated docking poses by manual docking followed by minimization. Analysis of docking poses allowed us to identify pharmacophores. From this information, virtual screening experiments using UNITY were performed. Among six candidates, 3-(3,7-dimethyloct-6-enylamino)propane-1,2-diol (Leadquest code name: 5755) was chosen for further development. Future work will involve synthesis of some derivatives of 5755 and biological experiments if any derivatives can control the biostimulation and improve reproductive efficiency in pigs.

• 복식
• /
• 제61권9호
• /
• pp.97-113
• /
• 2011

To develop the work clothes for the employees in the mechatronics industry in South Korea, a questionnaire survey on many aspects of the work clothes such as type, color, detailed design and function preference of the subject employees has been carried out in the study. The results throughout the survey highlighted certain functions such as extensibility, thermal and air permeability of importance for the work clothing performance. To improve the discomfort caused by some work motions (i.e. squatting down, ascending/descending the stairs, raising arms), more allowances were given to the measurements (i.e. body rise + 2cm and crotch depth + 1cm for squatting down pose; thigh circumference + 1cm and knee circumference + 1cm for ascending/ descending the stairs pose; chest circumference + 5~6cm and jumper length to the level of hip circumference line for raising arms pose) for work clothes patternmaking. The evaluation of the two types of spring/summer and winter work clothes' clothing comfort and wearer mobility suggested certain points to improve the clothing performance (e.g. ventilation slits on the back pleats, arm pits and collar band of the spring/summer suit using net material and lining for the winter suit using quilted thermal materials) and wearer mobility (e.g. pants hem buckles for the easy work motion), which also enabled to fulfill the workers' work clothes design preference.

• Safety and Health at Work
• /
• 제11권2호
• /
• pp.241-243
• /
• 2020

Coronavirus disease 2019 poses an occupational health risk to health-care workers. Several thousand health-care workers have already been infected, mainly in China. Preventing intra-hospital transmission of the communicable disease is therefore a priority. Based on the Systems Engineering Initiative for Patient Safety model, the strategies and measures to protect health-care workers in an acute tertiary hospital are described along the domains of work task, technologies and tools, work environmental factors, and organizational conditions. The principle of zero occupational infection remains an achievable goal that all health-care systems need to strive for in the face of a potential pandemic.

• 한국지하수토양환경학회:학술대회논문집
• /
• 한국지하수토양환경학회 2003년도 총회 및 춘계학술발표회
• /
• pp.430-433
• /
• 2003

Nitrogen pollution in urban and rural groundwater is a common problem and poses a major threat to drinking water supplies based on groundwater. In this work, the kinetics of nitrification-denitrification coupled reactions are modeled and new reaction modules for the RT3D code describing the fate and transport of nitrogen species, dissolved oxygen, dissolved organic carbon, and biomass are developed and tested. The proposed nitrogen transformations and transport model showed very good match with the results of other public codes.

• Biomolecules & Therapeutics
• /
• 제19권1호
• /
• pp.109-117
• /
• 2011

In this work, we have investigated the effect of polyoxyethylene alkyl ester nonionic surfactants on percutaneous permeation enhancement of a model drug, ketoprofen. We also investigated the mechanism involved in the enhancement using impedance and solubility measurement. Three groups of nonionic surfactants with different ethylene oxide content were studied. The permeation results showed that all surfactants enhanced the percutaneous absorption, irrespective of the molecular weight. The permeation results from PEG-45 monostearate (PEGMS45) were rather unexpected. Impedance and solubility results indicate that the mechanism involved in the enhancement of permeation by PEG-10 monooleate (PEGMO10) and PEGMS45 is rather different. The results from PEGMS45 suggest that it could be a potential candidate as a skin penetration enhancer with high molecular weight, which may poses less skin irritation and systemic side effect than the smaller surfactant molecules. Overall, this work provided some useful information on percutaneous transport enhancement and the mechanistic insights involved in skin permeation for these nonionic surfactants.

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2006년도 가을 학술발표논문집 Vol.33 No.2 (D)
• /
• pp.135-139
• /
• 2006

Today's social networking services have tens of millions of users, and are growing fast. Their sheer size poses a significant challenge in capturing and analyzing their topological characteristics. Snowball sampling is a popular method to crawl and sample network topologies, but requires a high sampling ratio for accurate estimation of certain metrics. In this work, we evaluate how close topological characteristics of snowball sampled networks are to the complete network. Instead of using a synthetically generated topology, we use the complete topology of Cyworld ilchon network. The goal of this work is to determine sampling ratios for accurate estimation of key topological characteristics, such as the degree distribution, the degree correlation, the assortativity, and the clustering coefficient.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
• /
• pp.186-188
• /
• 2003

Rail Route Alignment in hilly terrain is a difficult task to implement as several natural constraints poses threat to the safety and stability of the alignment. The conventional methods followed to find out the final location survey or the feasibility analysis for alignment is time taking consuming. Some times, due to inaccessibility of the terrain it becomes impossible to carry out such works. The construction works in hilly terrain, which are associated with the proposed alignment, are not same as carried out in plane areas due to a vast contrast between the two areas. Different geological structures such as faults, thrusts, synclines and anticlines are a big problem to carry out normal construction practices. Thus for a safe and stable railway route in the unstable hilly areas, it is required to carry out the feasibility analysis of the proposed alignment to assist the policy makers for a successful implementation of the alignment. In the present work Remote Sensing and GIS has been successfully used to carry out geological feasibility and slope stability analysis for rail route alignment work.

• International Journal of Computer Science & Network Security
• /
• 제21권3호
• /
• pp.48-54
• /
• 2021

Security is an important issue for wireless communications and poses many challenges. Most security schemes have been applied to the upper layers of communications networks. Since in a typical wireless communication, transmission of data is over the air, third party receiver(s) may have easy access to the transmitted data. This work examines a new security technique at the physical layer for the sake of enhancing the protection of wireless communications against eavesdroppers. We examine the issue of secret communication through Rayleigh fading channel in the presence of an eavesdropper in which the transmitter knows the channel state information of both the main and eavesdropper channel. Then, we analyze the capacity of the main channel and eavesdropper channel we also analyze for the symbol error rate of the main channel, and the outage probability is obtained for the main transmission. This work elucidate that the proposed security technique can safely complement other Security approaches implemented in the upper layers of the communication network. Lastly, we implement the results in Mat lab

• 디지털융복합연구
• /
• 제15권12호
• /
• pp.489-494
• /
• 2017

게임 애니메이션은 영상 애니메이션과 제작 과정에서 많은 차이가 있지만, 컴퓨터에서 작업하는 애니메이팅 방식은 크게 다르지 않다. 게임 애니메이션 제작에서도 영상 애니메이션에서의 원칙과 원리가 강조되어 제작되기 때문이다. 본 연구에서는 게임 애니메이션 제작 시 캐릭터의 포즈작업에 있어 여러 가지 고려해야 할 사항들 중, 동작의 방향과 에너지의 흐름을 알 수 있는 Line of Action에 대하여 고찰하고자 한다. Line of Action은 드로잉의 기초 이론으로 시작하여 셀 애니메이션부터 3d 애니메이션까지 포즈 작업에 있어 바이블의 역할을 하고 있다. 이러한 Line of Action이 게임 캐릭터의 포즈 작업에서 어떻게 적용되는지 알아보고자 선행연구를 통하여 이론적 배경을 살펴본 후, 3d 온라인 게임 '오버워치'의 영웅 캐릭터들의 포즈(pose)를 수집하고 직접 라인을 그려 포즈를 분석하였다. 그 결과 단순하고 명확한 동선을 가진 캐릭터들의 포즈가 캐릭터의 특징을 잘 표현하고 전달이 명확한 것을 알 수 있었다. 이 연구를 통하여 게임 애니메이션 제작에서 캐릭터 포즈의 표현 기법에 대하여 고찰하고자 하였으며, 실무에서 게임애니메이터들에게 중요한 참고자료가 되기를 기대한다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제16권6호
• /
• pp.1818-1832
• /
• 2022

Violence in the Internet era poses a new challenge to the current counter-riot work, and according to research and analysis, most of the violent incidents occurring are related to the dissemination of violence images. The use of the popular deep learning neural network to automatically analyze the massive amount of images on the Internet has become one of the important tools in the current counter-violence work. This paper focuses on the use of transfer learning techniques and the introduction of an attention mechanism to the residual network (ResNet) model for the classification and identification of violence images. Firstly, the feature elements of the violence images are identified and a targeted dataset is constructed; secondly, due to the small number of positive samples of violence images, pre-training and attention mechanisms are introduced to suggest improvements to the traditional residual network; finally, the improved model is trained and tested on the constructed dedicated dataset. The research results show that the improved network model can quickly and accurately identify violence images with an average accuracy rate of 92.20%, thus effectively reducing the cost of manual identification and providing decision support for combating rebel organization activities.