Objective: In the current work, we investigated the cytotoxic and apoptotic effects of Thymoquinone (TQ), an active compound of Nigella sativa (N. sativa) and Cis-platinum, on normal renal epithelial (GP-293) and human renal adenocarcinoma cell lines (ACHN). Methods: GP-293 and ACHN cell lines were cultured in Dulbecco's modified Eagle's medium (DMEM) with 10% Fetal bovine serum (FBS) and 1% penicillin plus streptomycin antibiotic. The MTT assay was used for cellular viability assessment. Viability of cells was observed using inverted light microscope 24, 48 and 72 h after exposure of the cells to various concentrations of TQ (1, 2.5, 5, 10, 50 and $100{\mu}g/ml$) and Cis-platinum (0.5, 1, 1.5, 2, 3, 6 and $12.5{\mu}g/ml$). Moreover, apoptosis was analyzed with a flow-cytometry method. The untreated cells were considered as control group. Results: Morphological changes such as reduced cell number and increased intercellular distance and reduced cell viability in ACHN and GP-293cell lines were observed in both TQ and Cis- platinum groups; however, Cis-platinum had greater effect on ACHN cell line than GP-293 cell line. In addition, GP-293 cell line was more sensitive to TQ compared to ACHN cell line. Furthermore, TQ and Cis-platinum had apoptotic effects on both ACHN and GP-293 cell lines. Conclusion: Our findings demonstrated that TQ and Cis-platinum had cytotoxic and apoptotic effects on both cell lines, However, GP-293 cell line was more sensitive to TQ. Additionally, Cis-platinum was more effective on ACHN cell line than on GP-293 cell line.
The Journal of the Institute of Internet, Broadcasting and Communication
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v.19
no.1
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pp.203-209
/
2019
In this work, a new land-specific resistance measuring device (GM) and a measuring probe (Grounding Rod) are connected to the WENNER quadrant as power-line communication (PLC). In groups of two (P1,P2) probes, five to ten probes are installed in series on the ground at intervals of 1m, 2m, 4m, 8m, and 16m, respectively. If the PLC signal from the GMD is detected by the receiver of the Probe 1 (P1) for measurement, the minute voltage and current for measurement flow from the PSD (power supply) attached to the probe to the ground, and then, through the soil between P1 and P2, enters the Probe 1 (P2). The resistance value is then measured by the principle of voltage drop due to ground resistance. Measure the earth resistance every T seconds up to 1 trillion and store the measured data on the Arduino Server mounted on the main equipment. Stored measurement data can be derived from formulas by Ohm's Law and from inherent resistance (here,). Data obtained in real time will be linked to CDGES programs installed on Main PC, enabling data analysis and real-time monitoring of the ground environment on land. In addition, a three-dimensional display is possible with 3D graph support by identifying seasonal characteristics such as temperature and humidity of land (soils). The limitations of the study will require specific application measures of Test Bed for commercial access to a model that has been developed and operated experimentally.
Kim, Nam Sook;Yoo, Geum Joo;Kim, Kyu Yeon;Lee, Ji Hyun;Park, Sung-Kwan;Baek, Sun Young;Kang, Hoil
Analytical Science and Technology
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v.32
no.2
/
pp.35-47
/
2019
In this study, high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was employed to detect 26 antidiabetic compounds in adulterated dietary supplements using a simple, selective method. The work presented herein may help prevent incidents related to food adulteration and restrict the illegal food market. The best separation was obtained on a Shiseido Capcell Pak(R) C18 MG-II ($2.0mm{\times}100mm$, $3{\mu}m$), which improved the peak shape and MS detection sensitivity of the target compounds. A gradient elution system composed of 0.1 % (v/v) formic acid in distilled water and methanol at a flow rate of 0.3 mL/min for 18 min was utilized. A triple quadrupole mass spectrometer with an electrospray ionization source operated in the positive or negative mode was employed as the detector. The developed method was validated as follows: specificity was confirmed in the multiple reaction monitoring mode using the precursor and product ion pairs. For solid samples, LOD ranged from 0.16 to 20.00 ng/mL and LOQ ranged from 0.50 to 60.00 ng/mL, and for liquid samples, LOD ranged from 0.16 to 20.00 ng/mL and LOQ ranged from 0.50 to 60.00 ng/mL. Satisfactory linearity was obtained from calibration curves, with $R^2$ > 0.99. Both intra and inter-day precision were less than 13.19 %. Accuracies ranged from 80.69 to 118.81 % (intra/inter-day), with a stability of less than 14.88 %. Mean recovery was found to be 80.6-119.0 % and less than 13.4 % RSD. Using the validated method, glibenclamide and pioglitazone were simultaneously determined in one capsule at concentrations of 1.52 and 0.53 mg (per capsule), respectively.
Proceedings of the Korean Institute of Information and Commucation Sciences Conference
/
2014.10a
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pp.320-323
/
2014
Today is going with the advancement of intelligent transportation systems and traffic environment and helping to provide safe and convenient service through a mobile device work with the popularization of the vehicle black box. The traffic flow by a variety of causes is constantly changing, it is often unable to prepare the driver, depending on external factors can not be controlled by the power of the public, leading to a major accident. The system needs to pass the real-time weather data in the inter-operator to prevent this. The proposed detection algorithm weather information delivered real-time weather information for this paper. The weather condition is detected by using the contrast between the histogram of the motion of the wiper and the clear day algorithm. In general, the wiper is worked in extreme weather conditions that will have a value different contrast due to rain or snow. Situation was considered clear, snowy conditions, such as using it on a rainy situation. First, designated as ROI (Region Of Interest) of the minimum area that can be detected in order to reduce the amount of calculation for the wiper, the wiper, which was detected through the operation of the threshold Thresholding the brightness of the vehicle wiper. In addition, we distinguish the value of each meteorological situation by using contrast. Results was obtained to 80% for the snow conditions, a rainy situation.
Journal of the Korea Organic Resources Recycling Association
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v.28
no.4
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pp.43-52
/
2020
As the membrane gas separation technology grows, various models were developed by numerous researchers to describe the separation process. In this work, the counter-current model was compared thoroughly with experimental data. Experimentally, hollow fiber membrane using CA module was prepared for the separation of biogas. The pure gas permeation properties of membrane module for methane, nitrogen, oxygen, and carbon dioxide were measured. The permeance of CO2 and CH4 were 25.82 GPU and 0.65 GPU, respectively. The high CO2/CH4 selectivity of 39.7 was obtained. the separation test for three different simulated mixed gases were carried out after pure gas test, and the gas concentration of the permeate at various stage-cut were measured from CA membrane module. Results showed that the experimental data agreed with the numerical simulation. A mathematical model has implemented in this study for the separation of biogas using a membrane module. The finite difference method (FDM) is applied to calculate the membrane biogas separation behaviors. Futhermore, the counter-current model can be considered as a convenient model for biogas separation process.
Park, Jihwan;Chung, Suwan;Lee, Seojoon;Song, Jinwoo;Kwon, Soonwook
Korean Journal of Construction Engineering and Management
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v.22
no.1
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pp.72-80
/
2021
Based on the previous year's statistics, 37% of buildings in South Korea are aged over 30 years. As the number of the aging buildings increases, so does the need for maintenance. Building maintenance involves a significant number of works; the work of 'maintenance manager' accounting for the largest part. Currently, the maintenance history record is mostly in drawing or handwritten form which makes reviewing the data highly time consuming. Therefore, to improve the convenience of maintenance works and optimize historical data management, the existing maintenance process was analyzed. Problems were derived and a smart device-based automation model was established. In order to establish a smart device-based automation model, ① general flow of facility management process was analyzed and related articles were reviewed, ② current maintenance process was optimized, ③ functional block diagram of BIM Data, COBie Data, IoT, and AR-based automated maintenance management model was created, ④ a smart device-based automated maintenance management model was constructed, ⑤ finally, the above system was verified by testing the aforementioned model in the field site, evaluating the time required for the maintenance process and reviewing maintenance history data against the current one.
Due to population growth and industrial development, the amount of industrial waste is increasing every year. In particular, in a thermal power plant using finely divided coal, a large amount of coal ash is generated after combustion of the coal. Among them, fly ash is recycled as a raw material for cement production and concrete admixture, but about 20% is not utilized and is landfilled. Due to the continuous reclamation of such a large amount of coal ash, it is required to find a correct treatment and recycling plan for the coal ash due to problems of saturation of the landfill site and environmental damage such as soil and water pollution. In recent years, the use of a fluid embankment material that can exhibit an appropriate strength without requiring a compaction operation is increasing. The fluid embankment material is a stable treated soil formed by mixing solidifying materials such as water and cement with soil, which is the main material, and has high fluidity before hardening, so compaction work is not required. In addition, after hardening, it is used for backfilling or filling in places where compaction is difficult because higher strength and earth pressure reduction effect can be obtained compared to general soil. In this study, the possibility of use of fluidized soil using high water content cohesive soil and coal ash is considered. And it is intended to examine the flow characteristics, strength, and bearing capacity characteristics of the material, and to investigate the effect of reducing the earth pressure when applied to an underground burial.
The Journal of the Convergence on Culture Technology
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v.7
no.1
/
pp.92-98
/
2021
Modern society needs constantly the rationality and the efficiency, and this flow of the time has become the paradigm of the whole society. This paradigm has a large influence on the architectural design and industry. Modern technology represented by the development of digital instrument and Information Technology through internet has created and developed two big trend, Parametric Design and BIM(Building information Modeling) in the architectural design and industry. These technologies, though created for different reasons, have a lot of influence on the architectural design and industry for a common purpose such as efficiency and rationality across the boundaries. In this context, this research will be embodied through the example about how parametric design should be made in the beginning of pre-design phase for BIM application. This research aims to consider the design process of Walt Diseny Consert Hall, the work of Frank O. Ghery, a deconstructivism architect, and to embody the shape of National Nederlanden Building in Prague, the Czech Republic, using parametric design tool in pre-design phase. This research later aims to be used as the basic data that can be applied to the entire architectural industry from a planning and a detailed design to a construction for the ultimate BIM application beyond the range of parametric design in pre-design phase. Later, the plan using the parametric design algorithm and BIM application in construction document phase will be conducted.
Journal of the Korea Society of Computer and Information
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v.25
no.12
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pp.279-291
/
2020
It has already been a few years since the word Fintech in Korea started to attract attention. These days, they believed that Fintech was just a boom, but these days it is recognized as a catalyst for financial transformation. Large venture companies are also launching demonstration experiments by creating new organizations that can respond to Fintech. It feels like a big tide is coming to the cautious and conservative financial industry. Finance is made up of digital information. Fintech is an evolutionary process in which finance, expressed by digital information, is transformed into information technology (IT) and human economic activities are reorganized. It is FinTech. You won't be able to understand the real effects of Fintech by sticking to individual applications like remittance payments or household account book services. Fintech is an innovation that changes the structure of economic activity itself. In fact, it is from now on that a big impact will come. In other words, now is the time when we are thinking of a dream that we have not yet dreamed of. In this paper, I will examine how fintech originated, spread to Korea, and how it intends to change Korea's finance in the future. Financial institutions have used the fruits of information technology advances in the direction of pursuing stability and stability, without major changes in the way they work. However, the movement of Fintech that started in Silicon Valley in the United States shows that the fruit can be used in other directions. The fruit of technological progress is expected to expand year by year in the future. It is a request of the times to use it to improve user convenience and to pursue innovation that is beneficial to society. We expect the flow of Fintech to accelerate innovation in the Korean financial industry.
Journal of Korean Tunnelling and Underground Space Association
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v.24
no.2
/
pp.129-151
/
2022
In the current work, a series of three-dimensional finite element analyses have been carried out to understand the behaviour of piles when the adjacent tunnelling passes underneath grouped piles with a reinforced pile cap. In the current study, the numerical analysis studied the computed results regarding the ground reinforcement condition between the tunnel and pile foundation. In addition, several key issues, such as the pile settlements, the axial pile forces, the shear stresses and the relative displacements have been thoroughly analysed, and the IoT platform based preliminary design guidelines were also presented. The pile head settlements of the nearest pile from the tunnel without the ground reinforcement increased by about 70% compared to the farthest pile from the tunnel with the maximum level of reinforcement. The quality management factor data of the piles were provided as API (Application Programming Interface) of various forms by the collection and refinement. Hence it has been shown that it would be important to provide the appropriate API by defining the each of data flow process when the data were created. The behaviour of the grouped piles with the pile cap, depending on the amount of ground reinforcement, has been extensively analysed, and the IoT platform regarding the quality management of piles has been suggested.
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