• Journal of Acupuncture Research
• /
• v.21 no.5
• /
• pp.249-256
• /
• 2004

Objectives : Wilson's disease is an autosomal recessive abnormality in the hepatic excretion of copper that results in toxic accumulation of the metal in liver, brain, and other organs. The purpose of this case study is to show a case with Wilson's disease treated with acupuncture therapy. Methods : We experienced a 17 year old male patient with a Wilson's disease whose main symptoms are neurological symptoms, such as spasticity, quadripleia and dysphagia. The patient was treated with acupuncture therapy for 3 weeks. Results : Spasticity was assessed by the modified Ashworth scale in an every week. 1. Lt. elbow, wrist and ankle joint improved Gr.III to Gr.II. 2. Rt. each joints and Lt. knee joint seemed to improve a little but no grade changed. Conclusions : This study is just one case and the period of acupuncture therapy is short, which make this case study less sufficient to decide the effect of acupuncture therapy. However, in this case study, acupuncture therapy seems somewhat effective to neurological symptoms of Wilson's disease, such as spasticity and quadriplegia. We suggest that oriental medicine should be studied to cure Wilson's disease from now on.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.4 no.2
• /
• pp.199-206
• /
• 2001

Purpose: To review the clinical and laboratory features of patients with Wilson disease at diagnosis. Methods: In this retrospective study, records of all 20 patients, who were diagnosed as having Wilson disease at the Paik hospital in Busan from 1990 to 2000, were reviewed. Results: Out of 20 patients, 12 pateints (60%) have hepatic presentation alone, 2 patients (10%) have neurologic presentation, 4 patients (20%) have hepatic and neuropsychiatric presentation, and one patient (5%) has hematologic presentation at diagnosis. One patient (5%) has neither symptom nor laboratory finding of Wilson disease except very low serum ceruloplasmin level and positive family history. Family screening test revealed 3 cases of Wilson disease. 12 patients were revealed to be combined with liver cirrhosis at diagnosis. Conclusion: Early diagnosis and treatment is very important in patients with Wilson disease. Children or adolescents who manifest symptoms of hepatitis, who has prolonged elevation of liver enzymes, and has family history of hapatitis of unknown origin, with mild hematologic or urinary abnormalities must be suspected to have Wilson disease. Also, in adolescents with extrapyramidal symptoms or other neuropsychiatric symptoms, liver function test should be done.

• Fire Science and Engineering
• /
• v.25 no.3
• /
• pp.113-118
• /
• 2011

The flash point is an important indicator of the flammability of a chemical. The minimum flash point behaviour (MFPB) is exhibited when the flash point of a mixture is below the flash points of the individual components. The identification of this behaviour is critical, because a hazardous situation results from taking the lowest component flash point value as the mixture flash point. In this study, the flash points for the n-butanol + n-decane and n-octane + n-propanol systems which exhibit MFPB, were measured by Tag open-cup apparatus. The experimental data were compared with the alues calculated by the Raoult's law, the van Laar equation and the Wilson equation. The calculated values based on the van Laar and Wilson equations were found to be better than those based on the Raoult's law. It was concluded that the van Laar and Wilson equations were more effective than the Raoult' law at describing the activity coefficients for non-ideal solution such as the n-butanol + n-decane and n-octane + n-propanol systems. The predictive curve of the flash point prediction model based on the Wilson equation described the experimentally-derived data more effectively than was the case when the prediction model was based upon the van Laar equation.

• Journal of Genetic Medicine
• /
• v.8 no.1
• /
• pp.53-57
• /
• 2011

Purpose: Wilson disease is an autosomal recessive disorder which causes excessive copper accumulation in the hepatic region. So far, ATP7B gene is the only disease-causing gene of Wilson disease known to date. However, ATP7B mutations have not been found in ~15% of the patients. This study was performed to identify any causative gene in Wilson disease patients without an ATP7B mutation in either allele. Materials and Methods: The sequence of the coding regions and exon-intron boundaries of the five ATP7B-interacting genes, ATOX1, COMMD1, GLRX, DCTN4, and ZBTB16, were analyzed in the 12 patients with Wilson disease. Results: Three nonsynonymous variants including c.1084A>G (p.Thr362Ala) in the exon 12 of the DCTN4 gene were identified in the patients examined. Among these, only p.Thr362Ala was predicted as possibly damaging protein function by in silico analysis. Examination of allele frequency of c.1084A>G (p.Thr362Ala) variant in the 176 patients with Wilson disease and in the 414 normal subjects revealed that the variant was more prevalent in the Wilson disease patients (odds ratio [OR]=3.14, 95% confidence interval=1.36-7.22, P=0.0094). Conclusion: Our result suggests that c.1084A>G (p.Thr362Ala) in the ATP7B-interacting DCTN4 gene may be associated with the pathogenesis of Wilson disease.

• Journal of the Korean Institute of Gas
• /
• v.14 no.5
• /
• pp.19-25
• /
• 2010

The flash points for the systems, o-xylene+n-pentanol and m-xylene+n-hexanol, were measured by using Tag open-cup tester(ASTM D1310-86). The experimental data were compared with the values calculated by the Raoult's law and the optimization method using van Laar and Wilson equations. The calculated values based on the optimization method were found to be better than those based on the Raoult's law. The predictive curve of the flash point prediction model based on the van Laar equation described the experimentally-derived data more effectively than was the case when the prediction model was based upon the Wilson equation.

• International Journal of Safety
• /
• v.10 no.1
• /
• pp.5-9
• /
• 2011

Two popular activity coefficient models, Wilson and NRTL equations have been used to correlate the published flash point data on the n-propanol + propionic acid and n-butanol + propionic acid systems through the optimization method. The results of these correlation were compared with the results calculated by Raoult's law. The optimization method were found to be better than those based on the Raoult's law. The optimization method based on the Wilson equation described the published data more effectively than was the case when the optimization method was based upon the NRTL equation.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• v.1 no.1
• /
• pp.105-125
• /
• 1997

In this paper we consider multigrid algorithms for solving elasticity problems by using Wilson's nonconforming finite element method. We consider two types of intergrid transfer operators which is needed to define the multigrid algorithm and prove convergence of $\mathcal{W}$-cycle mutigrid algorithm and uniform condition number estimates for the variable $\mathcal{V}$-cycle multigrid preconditioner.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
• /
• v.10 no.4
• /
• pp.423-430
• /
• 1998

Single phase heat transfer coefficients were measured for turbulent water flow in a micro-fin tube by using Wilson plot technique. An experiment for counterflow heat exchange between the micro-fin tube and its outer annulus passage was performed. The annulus side heat transfer resistance was varied and the overall heat transfer coefficients were measured. The single-phase heat transfer coefficients in a micro-fin tube were obtained by Wilson plot technique. Nusselt numbers based on the real heat transfer area and the nominal area were about 35% and 50% larger than those for smooth tube respectively Also, single-phase heat transfer correlations based on real heat transfer area and nominal area have been proposed for a micro-fin tube.

• Proceedings of the Korea Contents Association Conference
• /
• 2009.05a
• /
• pp.584-586
• /
• 2009

Dualized program for building Public Administration scholarship in Korea has been, in a sense, a result of theoretical tension between the two positions, politics/administration dualism vs. politics/administration monism. The program has maintained its integrity by its dependence on a foundational question, "Is administration a different field of action from politics?" Korean community for the study of public administration has maintained its oneness by internally asking this question even though the two external philosophical positions were relatively indubitable. Strating from the well-known changes in the community, this brief outline for the future full exegesis tries to read carefully one point shown in the second chapter of one of the most seminal proposals for foundation of modern Public Administration, one paragrahp in the second chapter of "The Study of Administration" by Woodrow Wilson. What was the contemporary meaning of Wilson's classic distinction made in 1887? Keeping this research question in our mind, we will attempt to prepare for the full understanding of a kind of internal distinction Wilson explicitly draws between the constitutional and the administrative.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.9 no.1
• /
• pp.108-113
• /
• 2006

In case of Wilson's disease complicated with hemolytic anemia and fulminant hepatic failure; plasma exchange or liver transplantation should be considered. We report an 11 year-old male with fulminant Wilson's disease who developed hemolytic crisis. He was recovered by exchange transfusion after 6 times of plasma exchange.