• Animal cells and systems
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• 제11권2호
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• pp.129-134
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• 2007

The initiation of eukaryotic DNA replication requires assembly of the pre-replicative complex (Pre-RC) through the concerted action of Orc, Cdc6, Cdt1 and Mcm2-7 complex during G1 phase. The pre-RC assembly licenses individual replication origins for the initiation of DNA replication and sufficient number of the pre-RC is essential for proper progression of S phase. However, it is not well known how cells recognize the completion of the pre-RC assembly before G1-S transition. In order to understand the cellular responses to the defects in pre-RC assembly, we depleted the known components of pre-RC proteins using the small interference RNAs in HeLa cells. Although the defects of pre-RC assembly by the depletion of the pre-RC proteins such as Orc2, Cdt1, Mcm2 & Mcm10 did not elicit the activation of Chk1- or Chk2-dependent checkpoint pathways, these cells still showed significant decrease in the cellular level of Cdc25A proteins. These results suggests that a novel checkpoint pathway exist in HeLa cells, which is not dependent upon Chk1 or Chk2 proteins and play essential roles in the cellular responses to the defects in the pre-RC assembly. Also, among those four proteins tested in this study, the depletion of Mcm10 and Cdt1 proteins significantly increased the apoptotic cell death in HeLa cells, suggesting that these proteins not only play roles in the pre-RC assembly, but also are involved in the checkpoint responses to the defects in the pre-RC assembly.

• 디지털융복합연구
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• 제16권4호
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• pp.363-369
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• 2018

본 연구는 마음챙김 훈련이 중등교사의 직무스트레스와 소진, 교사효능감에 주는 영향을 살펴보기 위해 실시하였다. G시 소재 중학교 및 고등학교 현직 교사 24명을 실험집단과 통제집단으로 나누어 훈련 프로그램을 시행하였다. 사전, 사후, 추후 세 시점에서 중등교사의 직무스트레스, 소진, 교사효능감을 측정하여 자료를 분석하였다. 마음챙김 훈련 프로그램의 효과를 검증하기 위해 시점과 집단 간의 상호작용 효과를 혼합변량(Mixed ANOVA)으로 분석하였다. 그 결과, 직무스트레스, 소진, 교사효능감에서 시점과 집단 간에 상호작용 효과가 유의함을 보여주었다. 또한 프로그램 효과의 지속성을 검증하기 위하여 실시 후 1개월 뒤의 효과를 대응표본 t-검정으로 분석한 결과 프로그램 효과가 지속된 것으로 나타났다. 본 연구는 중등교사의 직무스트레스 및 소진을 예방하고 업무를 효율적으로 수행할 수 있는 방법 중의 하나로서 마음챙김 훈련이 유의미함을 밝혔다는데 그 의의가 있다.

• 대한치과보철학회지
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• 제46권3호
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• pp.298-306
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• 2008

STATEMENT OF PROBLEM: Effect of surface treatment of ceramic under loading does not appear to have been investigated. PURPOSE: The aim of this study was to investigate the effect of surface treatment of esthetic ceramic, which is performed to increase the bonding strength, on the fracture stress under controlled cyclic loading condition. MATERIAL AND METHODS: Sixty 1.0 mm-thick specimens were made from Mark II Vitablocs (Vita Zahnfabrik, Germany) and divided into 3 groups: polished (control), sandblasted, and etched. Specimens of each group were bonded to a dentin analog material base including micro-channels to facilitate the flow of water to the bonding interface. Bonded ceramics were cyclically loaded with a flat-end piston in the water (500,000 cycles, 15Hz). Following completion of cyclic loading, specimens were examined for subsurface crack formation and subsequent stress was determined and loaded to next specimen by the staircase method according to the crack existence. RESULTS: There were significant differences of mean fatigue limit in the sandblasted (222.86 ${\pm}$ 23.42 N) and etched group (222.86 ${\pm}$ 14.16 N) when compared to polished group (251.43 ${\pm}$ 10.6 N) (P<.05; Wald-type pair-wise comparison and post hoc Bonferroni test). Of cracked specimens, surface treated group showed longer crack propagation after 24 hours. All failures originated from the radial cracking without cone crack. Fracture resistance of this study was very low and comparable to failure load in the oral cavity. CONCLUSION: Well controlled cyclic loading could induce clinically relevant cracks and fracture resistance of Mark II ceramic was relatively low applicable only to anterior restorations. Surface treatment of inner surface of feldspathic porcelain in the matsicatory area could influence lifetime of restorations.

• 한국건설관리학회논문집
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• 제11권2호
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• pp.137-146
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• 2010

최근 건설 프로젝트는 대형화, 복잡화, 고층화 그리고 발주방식의 다앙화에 따라 사업 초기단계부터 설계, 입찰, 계약, 시공 유지관리의 모든 과정을 연계하는 업무의 통합관리가 중요시되고 있다. 특히, 설계와 시공단계의 시공성 분석은 프로젝트의 목표와 성능의 극대화에 필수적인 주요 업무로 인식되고 있다. 하지만, 국내 건설실무에서의 현행 시공성 분석 업무는 2D 도면과 문서를 기반으로 수행되고 있으며, 프로젝트 단계별로 분석되어야 할 업무수행 범위, 방법과 절차가 체계적이지 못하고 또한 실무자의 경험적 지식에 의존하여 생성되는 분석정보의 일관성의 유지와 축적 및 활용이 어렵고, 효율적인 업무 수행을 위한 적절한 기술이나 기법의 활용이 미비한 실정이다. 이에 븐 연구는 현재 국내 건설 산업에서 수행되고 있는 시공성 분석의 업무내용을 규명하고, 그 실무적 한계를 파악하여, 최근 전 세계적으로 건설프로젝트에 활발히 도입 및 활용되고 있는 BIM의 개념과 기술의 시공성 업무에의 적용성을 분석하였고, 현행 시공성 분석 실무에의 적용 기대효과를 제시하였다.

• 대한치과교정학회지
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• 제48권2호
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• pp.113-124
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• 2018

The purpose of this case report was to introduce the concept of orthodontic and orthopedic treatment for a growing patient with Tessier number 0 cleft. A 5-year-old boy patient with Tessier number 0 cleft presented congenitally missing maxillary central incisors (MXCI), a bony defect at the premaxilla, a constricted maxillary arch, an anterior openbite, and maxillary hypoplasia. His treatment was divided into three stages: management of the bony defect at the premaxilla and the congenitally missing MXCIs using a fan-type expansion plate, iliac bone grafting, and eruption guidance of the maxillary lateral incisors into the graft area for substitution of MXCIs; management of the maxillary hypoplasia using sequential facemask therapy with conventional and skeletal anchorage; and management of the remaining occlusal problems using fixed orthodontic treatment. The total treatment duration was 15 years and 10 months. Class I canine and Class II molar relationships and normal overbite and overjet were achieved at the end of treatment. Although the long-term use of facemask therapy resulted in significant protraction of the retrusive maxilla, the patient exhibited Class III profile because of continued mandibular growth. However, the treatment result was well maintained after 2 years of retention. The findings from this case suggest that interdisciplinary and customized approaches are mandatory for successful management of maxillary hypoplasia, bony defect, and dental problems in Tessier number 0 cleft. Moreover, considering the potential of orthognathic surgery or distraction osteogenesis, meticulous monitoring of mandibular growth until growth completion is important.

• 한국인터넷방송통신학회논문지
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• 제18권1호
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• pp.15-21
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• 2018

데이터센터 네트워크의 자원을 효율적으로 활용하여 플로우들의 지연시간을 줄이기 위해서는 플로우 단위의 스케줄링보다는 패킷단위의 스케줄링이 적합하다. 따라서 최근에는 데이터센터 네트워크의 다중경로를 활용하여 패킷단위로 스케줄링을 수행하는 방식이 많이 제안되었다. 그러나 이로 인해 발생하는 순서 바뀐 패킷들이 표준 TCP 성능에 미치는 부정적인 영향을 줄이기 위해, 대부분의 방식들은 TCP 아래 계층에서 순서를 다시 맞추는 등의 보완방안을 필요로 한다. 본 논문에서는 데이터센터 네트워크의 대표적인 전송계층 프로토콜인 DCTCP가 다중경로상의 패킷단위 분산과 함께 사용될 때 어떤 성능을 보이는지 모의실험을 통해 조사한다. 모의실험 결과는 DCTCP가 큐의 길이를 짧게 유지할 수 있지만 혼잡신호에 따라 혼잡윈도우를 줄이는 방식 때문에 오히려 공평성 등의 측면에서는 기존 TCP보다도 낮은 성능을 가짐을 보여준다.

• 한국의상디자인학회지
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• 제16권3호
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• pp.135-149
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• 2014

Fur clothing as fashion items is expanding into casual & ladies's wear market as well as fur market. The interest of fur fashion is rising. So this study compares and analyzes the merchandising process of textile clothing also it of fur clothing by merchandising steps. Fur clothing has so many change factors at time of purchase by scarcity of raw material, price fluctuation, exchange rate and others. Therefore it is primarily about securing of raw material. As soon as plan of product is finished, the purchase of fur raw material has to be started while progress of design products for commercializing the fur clothing. The design of fur clothing is consist of material design, color design and shape design. And It makes a new trend & market as we are developing new & various treatments. The some of imported materials are transferred to the factory for being treated first dressing, fabric treatments and dyeing processing according to the design. The first treated materials are transferred to the sewing factory again for secondary treatments and finally inspected and shipped. During secondary treatments the fur has gone through various manufacturing process for using like fabric materials and it takes long time because almost work is running manually. Unlike fabric clothing, fur clothing's manufacturing method is complicated and various from material process to shape process as per feature. Therefore the merchandising with fur cannot make mass production also needs detail craftsmanship depending by expert's skills. On this wise the fur clothing takes long time to the completion thus it has been risky and costly.

• Tuberculosis and Respiratory Diseases
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• 제73권6호
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• pp.325-330
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• 2012

High-dose-rate endobronchial brachytherapy (HDREB) have been used as the treatment of early endobronchial cancer, as well as for palliation of advanced cancer. However, fatal hemoptysis can occur after HDREB at the rate of 7~32%. We report a case of massive hemoptysis due to radiation bronchitis developed after HDREB. A 67-year-old man was treated with HDREB for early endobronchial cancer on the left upper lobe bronchus. He complained of persistent cough from 4 weeks after completion of HDREB. Radiation bronchitis was observed on the bronchoscopy at 34 weeks, and it was progressed from mucosal swelling and exudate formation to necrosis and ulceration without local relapse. In addition, he died of massive hemoptysis after 15 months. The patient had no sign or radiologic evidences to predict the hemoptysis. This case implies that HDREB directly contributes to an occurrence of a fatal hemoptysis, and follow-up bronchoscopy is important to predict a progression of radiation bronchitis and fatal hemoptysis.

• Journal of Korean Biological Nursing Science
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• 제17권3호
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• pp.228-235
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• 2015

Purpose: Although the prevalence rate of chronic diseases is rapidly increasing due to an unhealthy diet in Korea, nurses may not have enough nutritional knowledge to educate their patients. This study investigated the level of nurses' nutritional knowledge for chronic diseases as well as for strokes, and the needs for nurses' nutritional education. Methods: This research is a descriptive research conducted from April to August of 2014, on 242 nurses who work with stroke patients, in two tertiary general hospitals in the city of Seoul, South Korea. Results: The average nutritional knowledge score of our subjects was $19.9{\pm}2.51$ (range 12-24). The correct response rate was 83% which was higher than expected. However, many nurses (31-66%) answered incorrectly on items such as 'Drinking low-fat milk is better than whole milk', and 'Seasoning with a large amount of soy sauce instead of salt can reduce sodium consumption'. We also found that nurses who received continuing education regarding nutrition scored higher than those who did not (p=.020). There was no correlation between nutritional knowledge and the need for nutritional education (r=.034, p=.601). Conclusion: The level of nutritional knowledge of the nurses was relatively low and irrelevant to the completion of nutrition courses during university or duration of experience. Rather, the relevance was higher when the nurse received nutrition-related training after graduating from university. Our results imply that continuous nutritional education is necessary for hospital nurses.

• 한국학교수학회논문집
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• 제5권1호
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• pp.135-145
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• 2002

Technical high school aims at educating students to acquire fundamental skill and technology required for being competent technicians, to be creative in adjusting themselves to the changing industrial society, and to do self-realization and find their ways toward the future on their own. To attain that goal and maximize learning effect, mathematics education is very important as prerequisite learning for technical subjects, as most technical courses in technical high school are basically based on mathematics. The purpose of this study was to discuss how mathematics education could be successfully linked to technical courses in an attempt to make it function properly as prerequisite learning for major subjects and facilitate students' technical learning. For that purpose, what problems the mathematics components of major subjects and the curriculum had was examined and the way to offer better education was presented. And there are some suggestions regarding mathematics education: First, technical mathematics should be newly inserted into technical high school curricula to help students learn major subjects in more efficient way. Second, most technical high schools are expected to just require tenth graders to complete a 10-stage mathematics course. In that case, they might find difficulties in learning major subjects when they are in their 11st and 12th grade. The curriculum should be designed to have 11st and 12th graders take mathematics education. Third, many students find a job after graduation, but the growing number of students go on to university to receive more education in the same field. Accordingly, there is a need to enlarge continuous progress plan, rather than completion-type one, to make students well-grounded technically. And mathematics should be taught in more classes as prerequisite subject for major courses. Fourth, mathematics elements necessary for each major subject should be outlined and announced to schools so that they could reorganize mathematics and major courses appropriately.