• The Journal of Korean Physical Therapy
• /
• 제5권1호
• /
• pp.17-24
• /
• 1993

The purpose of this study was to find out what changes in weight bearing in the both upper extremities occurred in response to Asymmetrical Tonic Neck Reflex by rotation of head in the quadruped position. The subjects for the study were 80 children (44 male, 44 female) who were neurologically normal. They were divided into two groups $6\~7$ year olds and $8\~9$ year olds. Paired t-test was applied as a atatistical method at the 0.01 level of significance. The results of this study are as follows; 1. In the neutral position of head, there was mort weight bearing on the left hand than the right in both of the two groups(p<0.01). 2. When the head was rotated to the right or left passively, there was more weight bearing on the hand of side to which the face was rotated(p<0.01). 3. When the head was rotated to the right or left actively, there us also more weight bearing on the hand of side to which the face was rotated(p<0.01). Therefore, it is possible to un Asymmetrical Tonic Neck Reflex to increase body weight for muscle strengthening in children with weakened muscles of the upper extremities. further studies are required for confirmation of these findings.

• 한국식생활문화학회지
• /
• 제18권4호
• /
• pp.396-405
• /
• 2003

The purpose of this study was to investigate the changes of obesity and depression level of obese children on body weight control program. The body weight control program included nutrition education, psychotherapy and exercise for weekly session during 9 months. The results from this study were as follows. A total of 27 obese children participated in this study. The average age of children was 11.7 years, 70% of children had regular exercise. Average exercise time was 1.2 hours and watching television time was 1.8 hours. Children's serum composition were within normal ranges. Rohrer index(RI) was significantly decreased to 163 from 167(p<0.001) and BMI was significantly decreased to 23.9 from 24.5(p<0.01) after body weight control program. There was not significant difference in depression score after body weight control program and there was not significant correlation between obesity and depression level. The response tendency of depression items indicated obese children had negative depression feelings and couldn't have hopeful mind to the future. But there were significant increase(p<0.05) in depression and hopeful mind in factor analysis. The suggestion and limitations of this study were discussed. These results suggest that body weight control program including nutrition education, exercise and psychotherapy may be effective for helping obese children.

• 한국환경보건학회:학술대회논문집
• /
• 한국환경보건학회 2004년도 International Conference Global Environmental Problems and their Health Consequences
• /
• pp.185-187
• /
• 2004

The co-administration of BPA and BBP induced slow weight gain compared with single administration in dams. Also, such mixture induced low neonatal body weights in next generation. The dams treated with BPA and BBP showed significant organ weight changes in liver, spleen exposed during lactational periods. But the dams exposed during lactational periods showed significant organ weight changes not only in liver, spleen but also in kidney, uterus and ovary. The F1 female rats exposed during lactation periods showed significant organ weight changes in liver, spleen, ovary. The F1 male rats showed significant organ weight changes in liver, kidney, epididymis, vesicular glands, prostate. However no clear synergistic effects of BPA and BBP could be found. Estrogen receptor ${\alpha}$ expression by BPA and BBP in the uterus(dam, F1 female) and testis(F1 male) were studied. There was no significant different $ER{\alpha}$ expression pattern between control and treated groups. But $ER{\alpha}$ expression were increased in F1 male testis and female uterus. F1 male showed distinct $ER{\alpha}$ expression, especially in the group of lactational combined exposure. Synergistic $ER{\alpha}$ expression was found by combined treatment of BPA and BBP.

• Toxicological Research
• /
• 제22권2호
• /
• pp.117-126
• /
• 2006

This study was conducted to obtain the acute information of the oral dose toxicity of lyophilized water extract of Picrorrhiza Rhizoma (PR) - dried underground stem of Picrorrhiza kurroa, having various pharmacological effects, in male and female mice. In order to calculate 50% lethal dose ($LD_{50}$), approximate lethal dose and target organs, test article was administered once by oral gavage to male and female ICR mice at 2000, 1000, 500 and 250 mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing with organ weight and histopathology of 12 types of principle organs. As the results, we could not find any mortality, clinical signs, changes in the body weight and gross findings except for hair loss, a significantly (p<0.05) increase of body weight gains in 2000mg/kg of PR extracts-dosing male group and some sporadic gross findings. In addition, no meaningful changes on the organ weight and histopathology of 12 types of principle organs were detected in the present study except for significantly (p<0.05) but dose independent changes on thymus, spleen and popliteal lymph nodes weights, and some sporadic accidental histopathological findings. The results obtained in this study suggest that the PR extract is non-toxic in mice and is therefore likely to be safe for clinical use. The $LD_{50}$ and approximate lethal dose of PR extracts in both female and male mice were considered as over 2000 mg/kg.

• Korean Journal of Acupuncture
• /
• 제27권3호
• /
• pp.47-56
• /
• 2010

Objectives : The moxibustion is the method using the heat stimulation done by attached and burned a moxa on a healing point or acupuncture point with chemical stimulation of a resin made from burning them. The purpose of this study is to find the physical and thermal characteristics of moxibustion in order to standardize the moxa therapy method. Methods : In this study, the thermal changes were observed by means of a testo 845 device, which is an infra-red thermometer to measure the thermal changes. Results & Conclusions : 1. The thermal changes on the external surface of moxibustion did not depend on the weight of the moxa; the external surface temperature was about $500^{\circ}C$. 2. The central thermal changes depend on the weight of moxa; the central temperatures ranged from $500^{\circ}C$ to $700^{\circ}C$. 3. The burning duration of moxibustion depend on the weight of moxa but that of external surface temperature did not depend on the weight of moxa in high degree : about $400^{\circ}C$. 4. The integral values of central and external temperature curves were proportional to the weight of moxa; that is central temperature curves were higher than that of external.

• Nutrition Research and Practice
• /
• 제17권6호
• /
• pp.1238-1254
• /
• 2023

BACKGROUND/OBJECTIVES: Weight loss via a mobile application (App) or a paper-based diary (Paper) may confer favorable metabolic and anthropometric changes. SUBJECTS/METHODS: A randomized parallel trial was conducted among 57 adults whose body mass indices (BMIs) were 25 kg/m² or greater. Participants randomly assigned to either the App group (n = 30) or the Paper group (n = 27) were advised to record their foods and supplements through App or Paper during the 12-week intervention period. Relative changes of anthropometries and biomarker levels were compared between the 2 intervention groups. Untargeted metabolic profiling was identified to discriminate metabolic profiles. RESULTS: Out of the 57 participants, 54 participants completed the trial. Changes in body weight and BMI were not significantly different between the 2 groups (P = 0.11). However, body fat and low-density lipoprotein (LDL)-cholesterol levels increased in the App group but decreased in the Paper group, and the difference was statistically significant (P = 0.03 for body fat and 0.02 for LDL-cholesterol). In the metabolomics analysis, decreases in methylglyoxal and (S)-malate in pyruvate metabolism and phosphatidylcholine (lecithin) in linoleic acid metabolism from pre- to post-intervention were observed in the Paper group. CONCLUSIONS: In the 12-week randomized parallel trial of weight loss through a App or a Paper, we found no significant difference in change in BMI or weight between the App and Paper groups, but improvement in body fatness and LDL-cholesterol levels only in the Paper group under the circumstances with minimal contact by dietitians or health care providers.

• 대한한방소아과학회지
• /
• 제23권1호
• /
• pp.141-158
• /
• 2009

Objectives The purpose of this study is to find out the effect of KyungOcGogamibang(KOGE) on the growth of rats. Methods First of all, we divided male Sprague-Dawley rats into 4 groups(KOGE1, KOGE2, KOGE3 and control group). Then KOGE1, KOGE2 and KOGE3 groups were administered with KOGE water extracts once a day at a dosage of 250, 500, 1,000mg/kg respectively for 3 weeks. The control group was administered with normal saline in the same manner. We measured the rat's body weight, amount of body weight increased, length of femur, serum GH, serum IGF-Ⅰ, serum TSH and serum testosterone after each week of administration. Results 1. There were significant changes of the rat's body weight, the length of the femur, the level of GH, IGF-Ⅰand TSH in KOGE1 groups. 2. There were significant changes of the rat's body weight, the length of the femur, the level of IGF-Ⅰand TSH in KOGE2 groups. 3. There were significant changes of the rat's body weight, the length of the femur, the level of IGF-Ⅰand TSH in KOGE3 groups. Conclusions According to the results above, rat in KOGE group have been increased their body weight, length of femur, serum GH, serum IGF-1 compared to the control group. This study shows that groups of KOGE have an effect on promoting the growth, thus it is expected to treat growth problems for children.

• Journal of Nutrition and Health
• /
• 제27권10호
• /
• pp.1048-1057
• /
• 1994

Nonobese NIDDM patients were studied were studied with respect to changes in visceral protein status, serum glucose and lipids and insulin secretion capacity before and after intake of enteral formula. Patients with renal or hepatic disease, gastrectomy, malabsorption, weight gain over past 6 months and poorly controlled blood glucose level were excluded. Eighteen patients served as case and administered, in addition of their usual diet, 400ml of enteral formula for 8 weeks. Another 18 patients participated in controls and had usual food intake for 8 weeks. In the begining, the levels of fasting and postprandial glucose, glycated hemoglobin, triglyceride, HDL, LDL, total cholesterol, albumin, total protein and transferrin and glucose response area on oral glucose tolerance test were not different between two groups. The response areas of insulin, C-peptide and free fatty acid and serum IGF-1 level were higher in the case than in the control group. Energy intake of patients given enteral formula exceeded their estimated energy requirements(108%) and they consumed a mean of 112g protein per day. Patients given enteral formula showed an increase in body weight(4.4%), serum transferrin(10%), IGF-1(13%) and triglyceride(34%) while controls showed no changes in those parameters at 8 weeks compared to initial values. There were no significant changes after 8 weeks in the levels of glucose, glycated hemoglobin, HDL, LDL, total cholesterol, total protein and albumin and response areas of glucose, insulin, C-peptide and free fatty acid in both groups compared to initial values. This study suggests that nutrition supplement with enteral formula can increase body weight and visceral protein status in nonobese NIDDM patients without changes in blood glucose. However, excessive calorie intake could temporarily increase serum triglyceride. In addition, this study indicates that serum transferrin and IGF-1 are more sensitive indicators to changes of protein intake than serum albumin and total protein.

• Toxicological Research
• /
• 제28권2호
• /
• pp.99-102
• /
• 2012

Bee venom (Apis mellifera L. BV) has been used as a cosmetic ingredient for anti-ageing, anti-inflammatory and antibacterial functions. The aim of this study was to evaluate the acute toxicity after a single dermal administration of BV, BV was administered to 2 groups of Sprague-Dawley (SD) male and female rats (5 animals/group) at doses of 0 and 1,500 mg/kg body weight (BW). Mortality, clinical signs, body weight changes and gross findings were continually monitored for 15 days following the single dose. There were no unscheduled deaths in any groups during the study period. No BV related clinical signs and body weight changes were observed in any groups during the study period. There were no abnormal gross findings at necropsy on day 15 after the treatment. On the basis of the above results, it was concluded that there were no treatment-related effect on mortality, clinical signs, body weight changes and gross findings in SD rats treated with a single dermal dose of BV at dose of 1,500 mg/kg BW. Therefore, the approximate lethal dose of BV was considered to be over 1,500 mg/kg/day for both sexes of rats. BV may provide a developmental basis for a cosmetic ingredient or external application for topical uses.

• Toxicological Research
• /
• 제24권1호
• /
• pp.79-86
• /
• 2008

This study was conducted to obtain information of the oral dose toxicity of low molecular fucoidan (LMF) in male and female mice. In order to calculate 50% lethal dose ($LD_{50}$) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250, 125 and 0 (vehicle control) mg/kg (body wt.). The mortality and the changes on body weight, clinical signs, gross observation and organ weight and histopathology of principle organs were monitored 14 days after LMF treatment. We could not find any mortalities, clinical signs, body weight changes and gross findings. In addition, significant changes in the organ weight and histopathology of principal organs were not observed except for some sporadic findings. The results obtained in this study suggest that LMF may not be toxic in mice and may be therefore safe for clinical use. The $LD_{50}$ and approximate LD in mice after single oral dose of LMF were considered over 2000 mg/kg in both female and male mice.