• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5973-5981
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• 2013

At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3117-3122
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• 2016

Background: Health-care research is a neglected discipline in Pakistan and research related to esophageal cancer (ranks 9th in Pakistani males and 5th in females) is no exception in this regard. Particularly, there are no data available to delineate the overall status of esophageal cancer epidemiological studies in Pakistan. This study describes the first ever effort to make a systematic quantification, in an attempt to provide a road-map to all stakeholders for designing appropriate epidemiological, diagnostic and therapeutic strategies. Materials and Methods: International (PubMed, ISI Web of Knowledge) and local (PakMedinet) scientific databases as well as Google search engine were searched using specified keywords to extract relevant publication. Well-defined inclusion criteria were implemented to select publications for final analyses. All data were recorded by at least 3 authors and consensus data were entered into and analyzed for descriptive statistics (such as frequencies, percentages and annual growth rates) using Microsoft Excel and SPSS software. Results: A total of 79 publications fulfilled the inclusion criteria including 20 publications for which full texts were not available. Of the 79 publications, 59 (74.6%) were original/research publications, 5 (6.3%) were case reports, 4 (5.1%) were research communications, 2 (2.5%) were review articles, 1 was (1.2%) correspondence and 8 (10.1%) were undefined categories. Only 13 (<20%) cities of Pakistan contributed towards the 79 publications. On average, only 1.9 relevant publications/year were published from 1976 (year of first publication) to the present. Alarmingly, a decline in the annual growth at -4.1% was recorded in the last six years. Conclusions: Esophageal cancer research is largely unfathomed in Pakistan. Urgent/dramatic steps are required by all concerned to address this common (and under reported) cancer of Pakistan.

• 대한한의학회지
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• 제31권5호
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• pp.1-11
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• 2010

Objectives: This study aimed to evaluate any clinical studies regarding rhinitis published by the Korean Oriental Medical Society and its sub-societies for future rigorous clinical research. Methods: Every article relevant to rhinitis was initially obtained from journals of the Korean Oriental Medical Society and its sub-societies by electronic search at journal web sites or manual searches. Journals were limited to those registered with the Korea Research Foundation. From initial findings, two independent reviewers selected clinical articles and these articles were further analyzed separately by predefined criteria according to prospective and retrospective studies. For prospective studies, quality assessment was also conducted. Results: From 36 initially obtained articles, 17 were finally analyzed. 2 articles were randomized controlled studies, 6 articles were prospective whereas 9 were retrospective. In the prospective articles, there were no randomized controlled trials and the other non-randomized studies had no control group with several problems of quality regarding pre-calculated study size and unbiased assessment. None of the retrospective studies described rhinitis diagnosis objectively and outcome measures were either non-relevant to rhinitis or non-validated. Conclusions: Further well-designed randomized controlled studies for rhinitis are mandatory and more rigorous non-randomized controlled studies should be conducted.

• 유통과학연구
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• 제10권11호
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• pp.89-99
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• 2012

Purpose - Mobile devices, especially mobile terminals capable of telecommunication and wireless connectivity, are leading the advancements in consumer electronics. Digital convergence drives the functions of various devices, such as cellular phones, MP3 players, personal digital assistants, and gaming, into a single device. This trend would continue and applications such as digital audio and video streaming (including personalized content delivery mechanisms) would soon be on a handheld device. As customers want mobile convergence devices, manufacturers are driving new initiatives in the emerging mobile device market. Given the roles played by device design and service content in user satisfaction of a mobile convergence device, this study focuses on identifying and measuring the constructs for the process by which user satisfaction is achieved. This study synthesizes the expectation-disconfirmation paradigm with empirical theories in user satisfaction. Device and service levels are separated, and nine key constructs for user satisfaction of mobile convergence devices are proposed. Insight into this process could help web-based businesses to improve user satisfaction, thus enhancing the effectiveness of e-commerce for sellers and buyers. Research design, data, methodology - This study draws on three users of mobile convergence devices as examples. To test there search model and hypotheses, survey questionnaires were sent to 607 mobile device users. Mobile device users were initially identified from several members, and subjects were randomly drawn. Data from 577 survey responses were finally analyzed. The unit of measurement and analysis in this research study is at a personal level. Results - The measurements for the constructs were developed and tested in a two-phase study. In the first phase, the device and service dimensions were identified, and instruments for measuring them were developed and tested. In the second phase, using the salient dimensions of the device and service as the formulating first-order factors, instruments were developed and empirically tested to measure satisfaction of the device and service. In measuring satisfaction of mobile convergence devices, the critical tasks are to identify the key constructs of such user satisfaction and to develop validated instruments to measure them. Hence, the results of this study have immediate implications for businesses and for research in user satisfaction of mobile convergence devices. Conclusions - This study provides reliable instruments for operationalizing key constructs in the analysis of user satisfaction of mobile convergence devices within the expectation-disconfirmation paradigm. Hence, convergence device makers will be able to examine whether their websites meet their customers' expectations by examining the device aspect of the mobile convergence device customers, and the service aspect expectations and disconfirmation. Moreover, the introduction of expectation and disconfirmation constructs brings the marketing aspect of convergence devices into focus for such retailers, an aspect crucial to the effective design of websites for online businesses. In addition,this study provides the metrics required to initiate future studies on user satisfaction of mobile convergence devices.

• 감성과학
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• 제10권4호
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• pp.613-622
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• 2007

최근 사운드 디자인은 기업에서 제품에서부터 마케팅, 웹에 이르기까지 기업이미지를 고려한 기억에 남을 만한 경험의 멜로디를 디자인하여 사용하고 있고, 생활환경이나 공공시설 등 여러 분야에서도 사운드가 각 분야의 아이덴티티 확립에 필요한 요소로 사용되고 있다. 지방자치단체시대를 맞이하여 각 지자체에서는 지역 활성화를 위한 지역 아이덴티티의 확립에 지역의 정체성 확보와 지역의 잠재력, 자원을 활용한 지역개발에 많은 관심을 기울이고 있다. 또한 도시이미지 제고를 위해 지역이미지통합사업(CIP) 등 적극적인 사업을 추진하고 있다. 그러나 이러한 일련의 사업들은 시각적인 측면에 치우치거나 인식의 부족으로 인하여 아이덴티티 구축에 한계가 있다. 소리의 고장인 전주에 소리에 관련된 축제와 대회가 많이 개최되고 있으나, 정작 소리에 대한 아이덴티티가 없는 상황이다. 따라서 전주만의 특색 있는 소리의 조건을 제시하고 이를 통해 지역이미지 활성화를 위한 아이덴티티 구축에 필요한 요소로서 활용될 수 있도록 자료를 제공하는 것이 본 연구의 목적이다. 본 연구에서는 지역 의 소리 이미지를 찾기 위한 소리 샘플은 지역민이 가장 선호하는 자연의 소리 중 한국의 아름다운 소리100을 사용하였다. 이중 선호 샘플을 추출하여 각 샘플에 대한 형용사이미지를 설문을 통해 요인 분석을 하였다. 분석 결과 전주지역의 특색 있는 소리이미지 요인으로는 조화, 강약, 대비, 문화성을 고려한 밝고, 경쾌하며, 편안한 소리 이미지를 도출할 수 있었다. 이는 지역이미지 활성화를 위한 아이덴티티 구축에 필요한 요소로서 활용될 수 있도록 자료를 제공하는 데 있다.

• 한방재활의학과학회지
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• 제30권1호
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• pp.79-93
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• 2020

Objectives While sciatic neuropathy is one of the common symptoms which have the lifetime incidence of 13~40%, still there is no consensus about the standardized and the most effective conservative treatment. In addition, the importance of systematic review and meta-analysis of preclinical are growing as they could suggest possible effective treatment strategy for future studies. Therefore, we conducted systematic review and meta-analysis to estimate analgesic effect of acupuncture on sciatica in rat models. Methods Systematic search was conducted for all controlled comparative preclinical trials which assessed analgesic effect of acupuncture in sciatica rat models. Database of PubMed, EMBASE, Web of Science, CNKI and 6 Korean databases were used. The primary outcome was pain, which is evaluated by stimulus behavior tests in rat models. We assessed the methodological quality with Systematic Review Centre for Laboratory Animal Experimentation's risk of bias tool. RevMan 5.3 was used for meta-analysis and subgroup analysis was conducted according to treatment site, acupuncture point, treatment period and frequency used in electroacupuncture. Results 14 studies were finally included following our inclusion criteria. The data from meta-analysis indicated that the acupuncture significantly improved the result values of behavior tests for pain evaluation, compared to no-treatment control group in animal models (standardized mean difference=4.43, 95% confidence interval 3.16 to 5.69, Z=6.84, p<0.00001; χ²=68.02, p<0.00001; I²=82%). The results of subgroup analysis indicate that acupuncture treatment of unilateral site, distal acupoints, longer treatment period and applying 2/100 Hz frequency in electroacupuncture could be more effective. Conclusions Systematic review and meta-analysis of animal studies are getting important for the future clinical studies and the improvement of heatlh care. Therefore the results of the study would provide evidence and better design for the forthcoming studies.

• The Korean Journal of Pain
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• 제22권2호
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• pp.141-145
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• 2009

Background: There is no assessment of internet sites that carry information on chronic pain disease. So we assessed the quality of information about postherpetic neuralgia available on Korean internet sites. Methods: The keywords 'postherpetic neuralgia', 'herpes zoster, neuropathic pain', 'herpes zoster, pain', 'herpes zoster' were searched in Korean on four search engines in Korea between the 1st to the 15th of May, 2009. We evaluated the outcome on two factors; the aspect of the contents which is subdivided into two categories, the content and authorship, and the technical aspect including web design, and efficiency. Results: A total of 26 internet sites were found. Among these sites, 6 (23%) informed by anesthesiologist. The average score of the 26 internet sites was only $37.4{\pm}20.1$ out of a total of 100. A mean score of the contents was $13.3{\pm}8.3$ out of 40 points, the authorship was $10.0{\pm}6.7$ out of 20 points, the design was $9.2{\pm}5.3$ out of 20 points, the efficiency was $6.8{\pm}4.3$ out of 20 points. When comparing the score between anesthesiologist and non-anesthesiologist, the contents was $18.7{\pm}7.4$ vs. $11.7{\pm}7.9$, the authorship was $13.4{\pm}4.7$ vs. $9.0{\pm}6.8$, the design was $12.5{\pm}4.2$ vs. $8.3{\pm}5.2$ and the efficiency was $6.8{\pm}4.5$ vs. $4.3{\pm}4.0$ (P < 0.05). Conclusions: There is a need for more accurate information about postherpetic neuralgia on the Korean internet by anesthesiologists.

• 한국지능시스템학회논문지
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• 제24권1호
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• pp.7-15
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• 2014

영상검색은 컴퓨터 비전과 데이터 마이닝 분야의 주요한 주제 중 하나이다. 현재 상용화된 영상 검색 시스템이 놀라운 성능을 보여주고 있음에도 불구하고, 폭발적으로 증가하는 웹상의 영상정보를 효율적으로 검색하기 위하여, 영상 검색 기술의 성능향상이 꾸준히 요구되고 있다. 재순위화는, 이런 요구를 만족시키기 위한 방법 중 하나로서, 영상 검색 시스템이 도출한 초기 결과를, 독자적인 알고리즘을 통해 연관도를 한 번 더 계산하고, 그에 따라 검색 결과의 성능을 향상시키는 방법이다. 지금까지 제안된 많은 재순위화 알고리즘이, 영상 검색 시스템이 영상의 시각적 정보를 사용하지 않는다는 가정하에 개발되어 왔지만, 현재 Google 과 Baidu 등 많은 상업적 영상 검색 시스템이 영상의 시각적 패턴에 대한 정보를 사용하기 시작함에 따라 이러한 가정이 어긋나고 있다. 또한, 영상 검색 시스템들이 독자적인 환경에서 개발되었기 때문에, 다수의 영상 검색 시스템의 협력으로 성능을 향상시킬 수 있을 것이라 예측되는 상황에도 불구하고, 이에 대한 연구가 부족했다. 본 논문에서는 이 두 가지 문제를 해결하기 위하여, 두 영상 검색 시스템이 사용하는 시각적 특징을 바탕으로, 두 시스템의 상보적인 정보를 이용하는 방법에 대하여 제안한다. 성능에 대한 평가는 가상 모형에서 이루어졌으며, 제안된 방법을 통하여 성능향상이 가능하다는 것을 보여준다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권4호
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• pp.278-305
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• 2016

Objective: The aim of this systematic literature review is to analyze the psychosocial interventions for children and adolescents after disasters. Methods: We conducted a review of the extant research literature from 1991 to 2015 via a comprehensive search of the MEDLINE, EMBASE, Cochrane CENTRAL, PubMed and PsyclNFO databases. The keywords employed in this research included: 'child', 'adolescent', 'youth', 'disaster', 'posttraumatic', 'psychosocial', 'therapy' and 'intervention'. The researchers followed the PRISMA guidelines. A total of 850 articles were screened for their eligibility and fifty-nine were found to meet the study criteria. The final data analysis was performed based on the disaster type, study design, type of intervention, sample size, age, school grade, number of sessions, setting of intervention delivery, providers, approach and parent involvement. Results: Countries worldwide have experienced various kinds of disasters, including earthquakes, hurricanes, vessel accidents, tornados, tsunamis, volcanic eruptions, war, fire, terrorism, and traffic accidents. The types of psychosocial intervention that were conducted after these disasters included: psychological first aid, psychological debriefing, psychoeducation, trauma focused cognitive behavior therapy, eye movement desensitization reprocessing, prolonged exposure therapy, group play therapy and arts therapy, project interventions, school-based interventions and web-based interventions. Conclusion: The findings of the systematic literature review suggest that an appropriate psychosocial intervention could be utilized as evidence-based mental health treatment for children and adolescents after disasters.

• 전자공학회논문지
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• 제50권5호
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• pp.25-38
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• 2013

미래의 무선 시스템은 사용자가 이동하며 생활하는 것을 지원해야 한다. 이동성은 매우 다른 특성을 가진 여러 개의 중첩 네트워크의 사용을 통해 제공 될 것이다. 이러한 네트워크는 오늘날의 인기 있는 데스크탑 서비스인 웹 브라우징, 쌍방향 멀티미디어 및 모바일 화상회의 등의 원활한 제공을 지원해야 한다. 따라서 이러한 모바일 시스템 설계의 주요 과제 중 하나는 서비스 품질(QoS) 보장이 될 것이며 이것은 애플리케이션이 다양한 네트워킹 인프라 아래에서 요구하는 것에 따라 보장해야 한다. 우리는 응용 프로그램에 QoS 보장을 제공하는 자원의 예약 및 적응 기법을 사용할 필요가 있다. 그러나 전체 서비스 예약 및 사전 구성은 지나치게 많아서 결과가 매우 비효율적이고 신뢰할 수도 없는 방식이다. 이것을 극복하기 위해 사용자의 이동성 패턴을 이용할 수 있다. 사용자의 움직임을 미리 알고 있을 경우, 예약 및 구성 절차는 사용자가 방문할 가능성이 있는 네트워크의 영역으로 제한할 수 있다. 제안한 Proxy-UMP기법은 다른 기법들에 비해 탐색비용의 증가에 민감하지 않으며, SMR(Session Mobility Ratio)증가에 따라 총비용의 증가율이 적은 것을 보여준다.