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http://dx.doi.org/10.18325/jkmr.2020.30.1.79

Effect of Acupuncture on Sciatica in Rat Models: Systematic Review and Meta-analysis  

Yoon, Ye-Ji (Department of Korean Rehabilitation Medicine, Kyung Hee University Korean Medicine Hospital at Gangdong)
Kim, Soojeon (Department of Korean Rehabilitation Medicine, Kyung Hee University Korean Medicine Hospital at Gangdong)
Cho, Jae-Heung (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Kyung Hee University)
Kim, Koh-Woon (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Kyung Hee University)
Song, Mi-Yeon (Department of Korean Rehabilitation Medicine, College of Korean Medicine, Kyung Hee University)
Publication Information
Journal of Korean Medicine Rehabilitation / v.30, no.1, 2020 , pp. 79-93 More about this Journal
Abstract
Objectives While sciatic neuropathy is one of the common symptoms which have the lifetime incidence of 13~40%, still there is no consensus about the standardized and the most effective conservative treatment. In addition, the importance of systematic review and meta-analysis of preclinical are growing as they could suggest possible effective treatment strategy for future studies. Therefore, we conducted systematic review and meta-analysis to estimate analgesic effect of acupuncture on sciatica in rat models. Methods Systematic search was conducted for all controlled comparative preclinical trials which assessed analgesic effect of acupuncture in sciatica rat models. Database of PubMed, EMBASE, Web of Science, CNKI and 6 Korean databases were used. The primary outcome was pain, which is evaluated by stimulus behavior tests in rat models. We assessed the methodological quality with Systematic Review Centre for Laboratory Animal Experimentation's risk of bias tool. RevMan 5.3 was used for meta-analysis and subgroup analysis was conducted according to treatment site, acupuncture point, treatment period and frequency used in electroacupuncture. Results 14 studies were finally included following our inclusion criteria. The data from meta-analysis indicated that the acupuncture significantly improved the result values of behavior tests for pain evaluation, compared to no-treatment control group in animal models (standardized mean difference=4.43, 95% confidence interval 3.16 to 5.69, Z=6.84, p<0.00001; χ2=68.02, p<0.00001; I2=82%). The results of subgroup analysis indicate that acupuncture treatment of unilateral site, distal acupoints, longer treatment period and applying 2/100 Hz frequency in electroacupuncture could be more effective. Conclusions Systematic review and meta-analysis of animal studies are getting important for the future clinical studies and the improvement of heatlh care. Therefore the results of the study would provide evidence and better design for the forthcoming studies.
Keywords
Sciatica; Acupuncture; Electroacupuncture; Animal model; Systematic review; Meta analysis;
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