• Journal of Pharmaceutical Investigation
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• v.36 no.3
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• pp.185-192
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• 2006

The purpose of this study was to determine the effects of iontophoresis on transdermal delivery of procaine hydrochloride in healthy volunteers, as well as to the synergic effect of high voltage current or ultrasound on the efficacy of transdermal delivery of iontophoresis. Forty healthy volunteers were randomly assigned to four groups topical application group (TA), iontophoresis group (IT), pre-treatment of high voltage current stimulation with iontophoresis (HVS + IT), and pre-treatment of ultrasound application with iontophoresis (US + IT). All subjects received procaine iontophoresis on the forearm using direct current with 4 mA f3r 15 minutes. All subject was measured the duration of local anesthesia, pressure pain threshold, pain perception threshold using rectangular wave at 0.2 ms, 1 ms, 50 ms of rectangular current stimulation after procaine iontophoresis. For comparisons of the sensory characteristics and efficacy of iontophoresis between the groups, an one-way ANOVA and Kruskal-Wallis were used. The significant difference the duration of local anesthesia were found between the groups (p<0.001). The local anesthetic duration of IT, HVS+IT were significantly longer than TA. Meanwhile, the local anesthetic duration of US+IT was significantly longer than HVS+IT, IT and TA group (p<0.05). Also, the pressure pain threshold, pain perception threshold at 0.2 ms, 1 ms, 50 ms were significant difference between the groups (p<0.001). All sensory characteristics including pressure pain threshold, pain perception threshold of IT, HVS+IT was significantly increased than TA, whereas, US+1T was significantly increased HVS+1T, IT and TA (p<0.05). This study showed that the procaine iontophoresis have increase the duration of local anesthesia concomitantly pressure pain threshold and pain perception threshold of sensory nerve fibers such as $A-{\beta}$, $A-{\delta}$ and C fiber. This findings suggest that the iontophoresis enhanced the transdermal delivery of drug ions in vivo. The combination of ultrasound application and iontophoresis synergized the transdermal delivery of drug ions. It is suggests that an electric field, mechanical and heating property of ultrasound may contribute to synergic effect due to temporary changes of structure in the stratum corneum.

• Journal of the Society of Naval Architects of Korea
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• v.37 no.1
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• pp.99-110
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• 2000

The damages due to wave impact loads are largely affected by impact pressure impulse and impact load area. The objective of this study is, as the third step, to perform dynamic structural analysis of bow flare structure of 300,000 DWT VLCC using LS/DYNA3D code, and to verify its dynamic structural behaviors. The impact load areas of stiffener space $1.5s{\times}1.5s$ and $2.5s{\times}2.5s$ are applied to bow flare structure part with relatively flexible stiffeners, and with stiff members such as stringers, webs etc., respectively, under the wave impact load with peak height 6.5MPa, tail 1.0MPa, and duration time 5.0msec. Through the dynamic structural analysis in this study, it might be thought that the structural strength of bow flare structure is generally sufficient for these wave impact load and areas, except that large damages were found at bow flare structure area with flexible wide span stiffeners.

• Journal of the Society of Naval Architects of Korea
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• v.36 no.4
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• pp.87-94
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• 1999

Empirical design is still used to avoid a structural damage because impact phenomenon and structural behaviour due to wave impact load can not examined accurately. The damage due to wave impact load is largely affected by impact pressure impulse and impact load area. The objective of this study is, as the second step, to develop an efficient scantling program of bow flare structure, and to predict its impact load area by comparing maximum dented deformations at center of idealized panel structure model of bow flare structure of 300k DWT VLCC using LS/DYNA3D code, which will be used for its verification of dynamic structural analysis, as the next step. Through this study, the impact load area was estimated as $1.5s{\times}1.5s$ stiffener space(s) in the case of panel with stiffeners and as $2.5s{\times}2.5s$, with stringers, under impact pressure curve with peak height 6.5MPa, tail height 1.0MPa, and duration time 5.0msec.

• Clinics in Shoulder and Elbow
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• v.19 no.1
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• pp.20-24
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• 2016

Background: Extracorporeal shock wave therapy (ESWT) is one of the treatment options used for patients with myofascial pain syndrome (MPS), although its effectiveness is controversial. The purpose of this study was to evaluate the effectiveness of ESWT in the treatment of MPS in terms of pain relief and functional improvements. Methods: We assessed 93 patients with MPS who underwent ESWT from March 2009 to July 2014. After exclusion of 25 patients with shoulder diseases, 68 patients were enrolled in the study. The mean follow-up period was 7.5 months (${\pm}4.2weeks$), and the average duration of symptoms was 5 months (range, 2-16 months). ESWT was applied to intramuscular taut bands and referred pain areas once a week for 3 weeks. Visual analog scale (VAS) pain scores and American Shoulder and Elbow Surgeons (ASES) scores were obtained at an initial assessment and at the 6-week, 3-month, and 6-month follow-up assessments. Results: VAS pain scores and ASES scores improved significantly after 3 sessions of ESWT (p<0.05). Both scores were improved, although not significantly, after 6 weeks (p>0.05). Conclusions: ESWT is an effective treatment option for patients with MPS.

• Journal of Sensor Science and Technology
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• v.9 no.3
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• pp.163-170
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• 2000

Optical frequency modulated fiber optic interferometric sensor was developed to sense the mechanical quantities, such as displacement, strain, force etc. It has been difficult to distinguish whether the increase of the mechanical quantities or the decrease of the quantities measured by the conventional fiber optic interferometric sensors because their signals only have a sinusoidal wave pattern related to the change of mechanical quantities. In this study, in order to measure the mechanical quantifies with the distinction of the changing direction of the quantities, the fiber of optic Michelson interferometric sensor was simply constructed by the laser light modulated with saw tooth wave pattern. The output signal of the sensor was controlled as the sinusoidal wave. The signal processing was based on the counting of the wave number of the output signal during constant time duration. The strain was determined by the cumulative value of the wave number producted by the gage factor. In order to verify the strain measurement capability of this sensor, the strain increase-decrease test was performed by universal testing machine installed with the aluminum specimen bonded with the fiber optic sensor and electrical strain gage. In the result of the test, the strain from the fiber optic sensor had a good agreement with the values from the electrical strain gage.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.6
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• pp.446-457
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• 2020

Crescentic sand bar in the coastal zone of eastern Korea is a common morphological feature and the rhythmic patterns exist constantly except for high wave energy events. However, four consecutive typhoons that directly and indirectly affected the East Sea of Korea from September to October in 2019 impacted the formation of longshore uniform sand bar and overall shoreline retreats (approx. 2 m) although repetitive erosion and accretion patterns exist near the shoreline. Widely used XBeach to predict storm erosions in the beach is utilized to investigate the morphological response to a series of storms and each storm impact (NE-E wave incidence). Several calibration processes for improved XBeach modeling are conducted by recently reported calibration methods and the optimal calibration set obtained is applied to the numerical simulation. Using observed wave, tide, and pre & post-storm bathymetries data with optimal calibration set for XBeach input, XBeach successfully reproduces erosion and accretion patterns near MSL (BSS = 0.77 (Erosion profile), 0.87 (Accretion profile)) and observed the formation of the longshore uniform sandbar. As a result of analysis of simulated total sediment transport vectors and bed level changes at each storm peak Hs, the incident wave direction contributes considerable impact to the behavior of crescentic sandbar. Moreover, not only the wave height but also storm duration affects the magnitude of the sediment transport. However, model results suggest that additional calibration processes are needed to predict the exact crest position of bar and bed level changes across the inner surfzone.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.473-481
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• 2000

Civil structures are becoming more flexible and lightly damped. When subjected to dynamic loads such as wind, earthquake and wave, vibration may be easily induced and lasted for lond duration. To suppress the wind-induced and earthquake-induced vibration of high-rise buildings, study on the development of a tuned mass damper has been carried out. Based on optimal design on passive tuned mass damper which is considered for a building subject to random excitations, a biaxial tuned mass damper was designed and developed. It is confirmed that the vibration levels of the test structure are reduced using the developed tuned mass damper.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.829-835
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• 2011

This paper aims for proposed the deflection limit on vibration serviceability of high-speed railway bridges considering passenger's comfort when a train passes a railway bridge. The vertical acceleration signals of passenger cars obtained from test were compared with them from the bridge-train transfer function by riding KTX. The deflections by KTX of seven high speed railway bridges were assumed as sine and haversine wave. The deflection limit on vibration serviceability of high-speed railway bridges considering passenger's comfort when a train passes a railway bridge duration can be expanded using bridge-train transfer function and bridge comfort limit considering serviceability due to bridge vibration. And it was compared to other allowable deflection limits of railway bridge design specifications.

• Korea-Australia Rheology Journal
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• v.21 no.2
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• pp.119-126
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• 2009

A numerical analysis is performed to investigate the effect of rotation on the blood flow characteristics with four different angular velocities. The artery has a cylindrical shape with 50% stenosis rate symmetrically distributed at the middle. Blood flow is considered a non-Newtonian fluid. Using the Carreau model, we apply the pulsatile velocity profile at the inlet boundary. The period of the heart beat is one second. In comparison with no-rotation case, the flow recirculation zone (FRZ) contracts and its duration is reduced in axially rotating artery. Also wall shear stress is larger after the FRZ disappears. Although the geometry of artery is axisymmetry, the spiral wave and asymmetric flow occur clearly at the small rotation rate. It is caused that the flow is influenced by the effects of the rotation and the stenosis at same time.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.40 no.6
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• pp.626-629
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• 1991

The negative wire of an electrolytic ozone generator, proposed by authors, has been contaminated by attaching the impurity particulate in tap water, which is called BUILD-UP phenomenon. The higher applied voltage and the larger wire diameter have shown the higher build-up rate, which makes the current reducing largely and concurrently the ozone production smaller. It is found that the positive electrode of the ozone generator has a strong SELF-CLEANING effect by detaching the impurity particulate from its surface, which, however, is used us a novel means of solving the build-up problem. As a result, the build-up problem can be solved effectively by applying an alternate square wave pulse voltage to the electrodes so as to get the self-cleaning ability on the both electrodes during each of the half pulse duration time.