• Korean Journal of Clinical Pharmacy
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• v.33 no.3
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• pp.195-201
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• 2023

Background: Hematocrit is usually measured from venous blood collected by invasive venipuncture. This study was performed to determine hematocrit accurately and precisely using minimally invasive volumetric absorptive microsampling (VAMS) technique. Such technique is to be applied to determining hematocrit in various clinical settings for the care, including therapeutic drug monitoring, of neonatal or epileptic patients, or patients with high risk of infection or bleeding. Methods: The study was performed using 31 VAMS samples obtained from 21 pancreatic cancer patients. Hematocrit was determined using the values of potassium concentrations obtained from blood in VAMS tips (Hct_VAMS). Hct_VAMS was compared with hematocrit measured from blood collected by venipuncture (Hct_VP). The accuracy and precision of Hct_VAMS in comparison to Hct_VP were evaluated using Bland-Altman plot, Deming regression and mountain plot. Results: Bland-Altman plot displayed a random scattering pattern of the differences between Hct_VAMS and Hct_VP with the mean bias of -0.010 and the 95% limit of agreement ranging from -0.063 to 0.044. Deming regression for Hct_VAMS and Hct_VP line demonstrated very small proportional and constant biases of 1.04 and -0.003, respectively. Mountain plot exhibited a narrow and symmetrical distribution of the differences with their median of -0.011 and central 95% range from -0.049 to 0.033. Conclusion: Hematocrit was accurately and precisely determined using less invasive VAMS technique. Such technique appears to be applicable to determining hematocrit in situations that venipuncture is not favorable or possible.

• Korean Journal of Optics and Photonics
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• v.18 no.6
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• pp.421-425
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• 2007

A new 3D rear projection display system using double-layer polarization-selective screen systems, one stacked in front of the other, has been developed. The front and rear screens are made of scattering polarizer films, and they either diffuse-scatter or transmit the incident light depending on the polarization state of the light. The near and for images are projected onto the front and rear screens, respectively, using light waves with mutually orthogonal polarization states. The new display system produces clear high-resolution images, which are visible over a wide range of viewing angle. It was found that the impression of depth is pronounced and eyestrain is only comparable to that by 2D display systems.

• Journal of the Korean Society for Nondestructive Testing
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• v.17 no.1
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• pp.11-22
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• 1997

It is very essential to get the accurate classification of defects in primary pressure vessel and piping welds for the safety of nuclear power plant. Ultrasonic testing has been widely applied to inspect primary pressure vessel and piping welds of nuclear power plants during PSI / ISI. Classification of flaws in weldments from their ultrasonic scattering signals is very important in quantitative nondestructive evaluation. This problem is ideally suited to a modern ultrasonic Pattern recognition technique. Here, a brief discussion on systematic approach to this methodology is presented including ultrasonic feature extraction, feature selection and classification. A stronger emphasis is placed on Fuzzy-UTSCS (UT signal classification system) as efficient classifiers for many practical classification problems. As an example Fuzzy-UTSCS is applied to classify flaws in ferrite pressure vessel weldments into two types such as linear and volumetric. It is shown that Fuzzy-UTSCS is able to exhibit higher performance than other classifiers in the defect classification.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.17 no.3
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• pp.223-231
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• 2005

When test tubes for PCM with melting point lower than a room temperature are installed vertically as the T-history method proposes, there exists a temperature distribution in the longitudinal direction by natural convection, which lowers the precision of measured heat-of-fusion. The purpose of the present work is to improve the precision by arranging the test tubes horizontally, while maintaining the simplicity and convenience. Assuming that the amount of heat transfer is very small through the vapor space formed in the upper part of the tubes by volumetric change, the obtained value by the T-history method using the latent heat period bounded by two inflection points is in good agreement with that of the literature. Also, the scattering of measured values by the proposed method decreases markedly compared to that of vertical positioning.

• Smart Structures and Systems
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• v.17 no.1
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• pp.31-43
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• 2016

Applications of ultrasonic tomography to concrete structures have been reported for many years. However, practical and effective application of this tool for nondestructive assessment of internal concrete condition is hampered by time consuming transducer coupling that limits the amount of ultrasonic data that can be collected. This research aims to deploy recent developments in air-coupled ultrasonic measurements of solids, described in Part 1 of this paper set, to concrete in order to image internal inclusions. Ultrasonic signals are collected from concrete samples using a fully air-coupled (contactless) test configuration. These air coupled data are compared to those collected using partial semi-contact and full-contact test configurations. Two samples are considered: a 150 mm diameter cylinder with an internal circular void and a prism with $300mm{\times}300mm$ square cross-section that contains internal damaged regions and embedded reinforcement. The heterogeneous nature of concrete material structure complicates the application and interpretation of ultrasonic measurements and imaging. Volumetric inclusions within the concrete specimens are identified in the constructed velocity tomograms, but wave scattering at internal interfaces of the concrete disrupts the images. This disruption reduces defect detection accuracy as compared with tomograms built up of data collected from homogeneous solid samples (PVC) that are described in Part 1 of this paper set. Semi-contact measurements provide some improvement in accuracy through higher signal-to-noise ratio while still allowing for reasonably rapid data collection.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.1
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• pp.1-17
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• 2020

Three-dimensional microscopic approaches in histopathology display multiplex properties that present puzzling questions for specimens as related to their comprehensive volumetric information. This information includes spatial distribution of molecules, three-dimensional co-localization, structural formation and whole data set that cannot be determined by two-dimensional section slides due to the inevitable loss of spatial information. Advancement of optical instruments such as two-photon microscopy and high performance objectives with motorized correction collars have narrowed the gap between optical theories and the actual reality of deep tissue imaging. However, the benefits gained by a prolonged working distance, two-photon laser and optimized beam alignment are inevitably diminished because of the light scattering phenomenon that is deeply related to the refractive index mismatch between each cellular component and the surrounding medium. From the first approaches with simple crude refractive index matching techniques to the recent cutting-edge integrated tissue clearing methods, an achievement of transparency without morphological denaturation and eradication of natural and fixation-induced nonspecific autofluorescence out of real signal are key factors to determine the perfection of tissue clearing and the immunofluorescent staining for high contrast images. When performing integrated laboratory workflow of tissue for processing frozen and formalin-fixed tissues, clear lipid-exchanged acrylamide-hybridized rigid imaging/immunostaining/in situ hybridization-compatible tissue hydrogel (CLARITY), an equipment-based tissue clearing method, is compatible with routine procedures in a histopathology laboratory.

• Korean Journal of Remote Sensing
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• v.29 no.3
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• pp.307-314
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• 2013

The Bidirectional Reflectance Distribution (BRD) effect is critical to interpret the surface information using remotely sensed data. This effect was caused by geometric relationship between sensor, target and solar that is inevitable effect for data of optical sensor. To remove the BRD effect, semi-empirical BRDF models are widely used. It is faster to calculate than physical models and demanded less observation than empirical models. In this study, Ross-Li kernel and Roujean kernel were used respectively in National Aeronautics and Space Administration (NASA) and European Organization for the Exploitation of Meteorological Satellites (EUMETSAT) that are used to compare each other. The semi-empirical model consists of three parts which are isotropic, geometric and volumetric scattering. Each part contained physical kernel and empirical coefficients that were calculated by statistical method. Red and NIR channel of SPOT/VEGETATION product were used to compute Nadir BRDF Adjusted Reflectance (NBAR) over East Asia area from January 2009 to December 2009. S1 product was provided by VITO that was conducted atmospheric correction using Simplified Method of Atmospheric Correction (SMAC). NBAR was calculated using corrected reflectance of red and NIR. Previous study has revealed that Roujean geometric kernel had unphysical values in large zenith angles. We extracted empirical coefficients in three parts and normalized reflectance to compare both BRDF models. Two points located forest in Korea peninsular and bare land in Gobi desert were selected for comparison. As results of time series analysis, both models showed similar reflectance change pattern and reasonable values. Whereas in case of empirical coefficients comparison, different changes pattern of values were showed in isotropic coefficients.