• Journal of Veterinary Science
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• v.24 no.1
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• pp.15.1-15.13
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• 2023

Background: Inactivated vaccines are limited in preventing foot-and-mouth disease (FMD) due to safety problems. Recombinant virus-like particles (VLPs) are an excellent candidate for a novel vaccine for preventing FMD, given that VLPs have similar immunogenicity as natural viruses and are replication- and infection-incompetent. Objectives: The 3C protease and P1 polyprotein of type O FMD virus (FDMV) was expressed in yeast Hansenula polymorpha to generate self-resembling VLPs, and the potential of recombinant VLPs as an FMD vaccine was evaluated. Methods: BALB/c mice were immunized with recombinant purified VLPs using CpG oligodeoxynucleotide and aluminum hydroxide gel as an adjuvant. Cytokines and lymphocytes from serum and spleen were analyzed by enzyme-linked immunosorbent assay, enzyme-linked immunospot assay, and flow cytometry. Results: The VLPs of FMD were purified successfully from yeast protein with a diameter of approximately 25 nm. The immunization of mice showed that animals produced high levels of FMDV antibodies and a higher level of antibodies for a longer time. In addition, higher levels of interferon-γ and CD4⁺ T cells were observed in mice immunized with VLPs. Conclusions: The expression of VLPs of FMD in H. polymorpha provides a novel strategy for the generation of the FMDV vaccine.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.3
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• pp.1167-1187
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• 2020

With the development of medical imaging technology, image registration has been widely used in the field of disease diagnosis. The registration between different modal images of brain magnetic resonance (MR) is particularly important for the diagnosis of brain diseases. However, previous registration methods don't take advantage of the prior knowledge of bilateral brain symmetry. Moreover, the difference in gray scale information of different modal images increases the difficulty of registration. In this paper, a multimodal medical image registration method based on image segmentation and symmetric self-similarity is proposed. This method uses modal independent self-similar information and modal consistency information to register images. More particularly, we propose two novel symmetric self-similarity constraint operators to constrain the segmented medical images and convert each modal medical image into a unified modal for multimodal image registration. The experimental results show that the proposed method can effectively reduce the error rate of brain MR multimodal medical image registration with rotation and translation transformations (average 0.43mm and 0.60mm) respectively, whose accuracy is better compared to state-of-the-art image registration methods.

• The Journal of the Korea Contents Association
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• v.10 no.1
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• pp.286-294
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• 2010

Complex Regional Pain Syndrome(CRPS) is a chronic neruopathic pain syndrome, most frequently encountered after trauma, nerve injury, fracture, cerebral vascular accident(CVA), spinal injury, and surgery to a limb, and affected by diverse factors such as disease process, intervention method, and other biopsychosocial components. Occupational therapy as a multidisciplinary treatment approach may be potentially useful when simultaneously targeting such biological, psychological, and social components. Biological treatment can focus on increasing functional use of extremity for promoting independence. Psychological intervention can include relaxation/biofeedback training and cognitive-behavioral treatments, and social approach can focus on recreational therapy and vocational rehabilitation. Occupational therapy will encourage functional restoration, pain management, and regaining of psychological components with collaboration between different disciplines.

• Journal of Korean Academy of Nursing
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• v.35 no.7
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• pp.1343-1352
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• 2005

Purpose: This study was designed to identify the degree of self-image and social support among Korean-Chinese adolescents and investigate the relationship between these variables. Method: A total of 621 Korean-Chinese adolescents in five middle schools in YanBian, China were recruited from March 1st to the 9th, 2005. Data was analysed using descriptive statistics, Pearson correlation coefficient, t-test, and ANOVA with the SPSS 11.5 program. Result: In Korean-Chinese adolescents, the total self-image score was statistically different for age, parents' education status, parents' job and living with parents. In the 12 subscales, scoresof emotional tone, impulse control, sexuality, social functioning, vocational attitudes and self-reliance had significant differences between groups regarding gender. The total self-image was in the average range. However, areas of mental health and family function were lower than average and the scale of idealism washigher than average. The adolescents perceived parent's support was higher then friend's support. There was a positive correlation between self-image and social support. Conclusion: The findings suggest there is a need to examine self-image and social support of Korean- Chinese adolescents according to their parents' marital status and a need to develop a program to help these broken family's adolescents.

• Research in Community and Public Health Nursing
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• v.12 no.1
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• pp.125-141
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• 2001

The purpose of this study was to investigate the factors affecting hearing loss in adolescent's use of PCPs, and to give the basic data for adolescent's hearing conservation program development and prevention education against their hearing loss. This study was a descriptive research about three factors affecting hearing loss; the knowledge and attitude about noise, the perception of hearing loss and the hearing threshold. The subjects of this study were 383 students in two general high schools and two vocational high schools in Teagu. They have been using PCPs but with no current or past ear disease. This study was carried out from Sep. 1. 2000 to Oct. 24, 2000. The instrument used for the knowledge and attitude about noise was a questionnaire developed by Rhee. Kyung Yong and Yi. Kwan Hyung(1996). The instrument used for the perception of hearing loss was a Smith Hearing Screening Questionnaire. A Belton Model 112 Audiometer. air-conduction hearing test instrument. was used for the hearing threshold. Data was analysed by a SPSS/Win 10.0 program with frequency. percentage, t-test. ANOVA and pearson correlation. The results of this study were as follows; 1. The average of concern about hearing scored the highest $3.66{\pm}0.70$. The average of perceived susceptibility scored $2.64{\pm}0.85$ and the average of knowledge about noise scored $2.13{\pm}0.56$. The average of total knowledge and attitude about noise scored $2.82{\pm}0.46$. The average of discomfort of hearing loss($2.51{\pm}0.81$) scored higher than that fear of hearing loss($1.35{\pm}0.53$). The average of total perception of hearing loss scored $1.93{\pm}0.59$. The hearing threshold of the subjects scored the highest at 500Hz(Lt. $23.21{\pm}6.62$, Rt. $23.39{\pm}7.02$) and scored higher in order of 1000Hz, 2000Hz, 4000Hz and 8000Hz. 2. The knowledge and attitude about noise and the perception of hearing loss were both affected only by one important characteristic, which was general and vocational high schools. The knowledge and attitude about noise raked (t=5.258, p=0.000), and perception of hearing loss raked(t=2.241. p=0.026). However. several other important characteristics also impacted significantly on the knowledge and attitudes about noise. They included grade (t = 1. 987. p=0.048), father's education(F=2.745. p=0.043), marks(F=3.157, p=0.044), drinking(t=2.307, p=0.022) and smoking(t=2.587, p=0.010). The left hearing threshold differed significantly by sex at 1000Hz(t=5.175, p<0.001) and 8000Hz (t=3.334, p<0.01). According to general and vocational high schools (p<0.001), at 500Hz (t=-5.056), 1000Hz (t=-5.253), 2000Hz (t=-4.905), 4000Hz (t=-4.704) and 8000Hz (t=-5.204) significant differences were also shown. Marks were significant at 1000Hz (F=3.824, p<0.05) and drinking was found to be significant at 500Hz(t=2.203, p<0.05). The right hearing threshold differed significantly by sex at l000Hz(t=5.557. p<0.001). 4000Hz(t=2.234. p<0.05) and 8000Hz (t=2.730. p<0.01). According to general and vocational high schools(p<0.001) at 500Hz (t=-4.730), 1000Hz(t=-6.271). 2000Hz (t=-4.573). 4000Hz(t=-3.554) and 8000Hz (t=-3.405) significant differences were also shown. Grades impacted at 500Hz(t=2.201. p<0.05) and 4000Hz(t=2.511. p<0.05), while marks were significant at l000Hz(F=4.1l5. p<0.05) and drinking was significant at 500Hz(t=2.333. p<0.05). 3. The left hearing threshold in accordance with use of PCPs differed significantly at 2000Hz(F=2.996. p=0.03l) according to volume level and at 8000Hz(F=2.197. p=0.022) according to duration${\times}$hours per day. The right hearing threshold differed significantly at l000Hz(F=3.075. p=0.028) according to volume level and at 8000Hz(F=2.925. p=0.034) according to duration. 4. The knowledge and attitudes about noise showed a light positive correlation with the perception of hearing loss. A positive correlation was shown. as stated previously in all Hz, between the left hearing threshold and the right hearing threshold, especially the highest correlation at 2000Hz(r=0.761. p=0.000). This study has shown that the factors related to adolescent's use of PCPs are important as they impact significantly an adolescent's hearing. These results then indicate that in future, when designing a hearing conservation program and prevention education this data should be considered.

• Korean Journal of Health Education and Promotion
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• v.14 no.2
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• pp.17-42
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• 1997

From September 2, 1995 through October 31, this questionnaire was made by the 1, 200 industrial workers who work for 15 enterprises of 5 types of business. And it was for helping to devise a policy and to develop a program for industrial workers' health promotion by understanding the consciousness behavior level of industrial workers in our country and the related factors which are under the influence of it and health promotion behavior. The summary and conclusions are as follows. 1. In health promotion score level by related factors, the health diagmosis level score was 7. 37(81.9/100) of the perfect score 9, nutrition level score was 7.00(77.8/100), health education behavior level score was 6.00(66.7/100), exercise behavior level score was 6.01(66.8/100), occupational disease knowledge level score was 6.00(66.7/100). 2. Health diagnosis behavior level was significantly high when the age is older, when the occupation term is longer, when the economic status is better. And wjem tje satosfoed degree for vocational aptitude, working environment, and the education contents. 3. Nutrition (dietary habit) status level was high in men, in the age group of 40 over, in the group of having their spouse, in the group of being paid over one million won a month, in the upper economic classes (P〈0.001). It was also high in graduates middle school and in daytime workers (P〈0.05). 4. Health education behavior level was high in the older ahe hroup, in a single life (separation by death, divouce, separation) and in the longer occupation term(P〈0.001). 5. Exercises behavior level was high in men, in the workers who are paid 500～990 thousand won a month, in the better economic classes(P〈0.01). 6. Knowledge level on an occupational disease was high in men, in the older age group, in the group of having a spouse, In the workers who are paid 500～990 thousand won a month, in the group of having a longer occupation term, and in the residents living not in a large city(P〈0.01). 7. When health status was higher, health promotion behavior, behavior level, health diagnosis (P〈0.001), nutrition(P〈0.05), health education behavior (P〈0.05), exercise behavior(P〈0.01) and the knowledge level on an occupation disease was high. 8. The main factors which are under the influence on the degree of practicing healthy life were the level of knowledge and behavior, sex, his/her health status, and the satisfied degree of working environment. These variables could explain it 18.0%. 9. The factors which are under the influence on health promotion behavior and behavior levels were the variables of the satisfied degerr of education contents, sex, health knowledge, economic status, health status, occupation terms, monthly income, working tiredness. These variables could explain it 21.3%. By these results, it is inportant for industrial workers' health promotion to level up the health diagnosis behavior, dietary habit considering nutrition, behavior on health education, behavior for exercise, and knowledge on an occupational disease. Especially we should develop the proper program considered sex, health status, satisfied degree of working environment and education contents, economic status, eccupation terms, knowledge on health, and behavior level. Because health promotion business gies in gear with productivity promotion.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.505-509
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• 2012

Background: Matrix metalloproteinases (MMP) are proteolytic enzymes that are essentially involved in turnover of the extracellular matrix (ECM). The aim was to investigate the diagnostic value of MMP-7 and MMP-10 as tumor markers in pleural effusion (PE) and evaluate the value of combining MMP-7, MMP-10 and carcinoembryonic antigen (CEA) assays as diagnostic aids for malignant cells. Materials and Methods: A total of 179 patients with PE (87 malignant and 92 benign) were included in this study. The levels of MMP-7 and MMP-10 were measured using ELISA. Results: Values for MMP-7 and MMP-10 were significantly higher in malignant PE than those in benign PE (P<0.01). Among all variables evaluated, logistic regression found that MMP-7 and MMP-10 were significantly correlated with the presence of malignant disease (P<0.01). Analysis of receiver operating characteristics (ROC) curves showed that the area under the curve of MMP-10 (0.806) was significantly larger than that of MMP-7 (0.771) and CEA (0.789) (P<0.01). With parallel interpretation, the combination of MMP-10 and CEA achieved the higher sensitivity of 94.6%. The combination of MMP-7 and CEA in serial interpretation was able to boost the specificity to 95.7%. The combination of MMP-7, MMP-10 and CEA produced better sensitivity, specificity, PPV and NPV than MMP-7 and MMP-10 alone. Conclusion: MMP-7 and MMP-10 in PE may represent helpful adjuncts to conventional diagnostic tools in ruling out malignancy as a probable diagnosis, thus guiding the selection of patients who might benefit from further invasive procedures.

• The Journal of Internal Korean Medicine
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• v.13 no.2
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• pp.77-83
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• 1992

Clinical studies were done on 43 cases of Tan-San(呑酸) patient which were treated by outpatient, took medicine with Ge-Wool-Hwa-Dam-Jeon (開鬱火痰煎) in Dept. of 2nd clinic, Christian Oriental Hospital from June in 1991 to end of May in 1992. The results were as follows. 1. The ratio of sex and age was 37.2% males (16 cases) and 62.7% females (27 cases) somewhat higher than males, In the age distribution, the highiest decade was thirtieth decade 48.83% (21 cases). 2. In the vocational distribution, housewives 51.16% (22 cases), commerces 23.25% (10 cases), company employee, teachers, students were in order of frequency and in the regional distribution was city 93.02% (40 cases), from village 6.97% (3 cases). 3. In the type distribution, the highiest frequency was Gan-Gi-Beom-Wi(肝氣犯胃) type 53.48% (23 cases), and Sik-Jeok (食積) 18.8% (8 cases), Bi-Gi-Heo(脾氣虛) 16.27% (7 cases) were in order of frequency. 4. In the western name of a disease distribution, the highiest frequency was chronic gastritis 37.20% (16 cases). 5. In the period of history, the highiest freguency was between six months and one year 23.25% (10 cases), furthermore between 5 years and 10 years 2.32% (40 cases). 6. In the treatment period, the highiest frequency was between 3 weeks and 4 weeks 38.46% (10 cases), and between one month and 2 months 30.76% (8 cases) was in order of frequency. 7. Treatment progress found out progressed 74.2% (26 cases) among the 35 cases which was known treatment progress.

• Korean Journal of Head & Neck Oncology
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• v.16 no.2
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• pp.191-195
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• 2000

Objectives: Despite various attempts to preserve the normal voice in advanced laryngeal cancer, it is inevitable for many advanced laryngeal cancer patients to undergo total laryngectomy and thus making a trade off between quality and quantity of life. Laryngectomees are faced with voice loss, change in physical appearance and health deterioration which hinder their efforts to rehabilitate back into their family and employment leading to poor quality of life. The objectives of this study were to evaluate the quality of life in long term surviving laryngectomees to, define the factors which are most important in determining their present quality of life and to propose a theoretical model for quality of life after laryngectomy in Korea. Materials and Methods: From 1986 to 1995, 120 laryngectomees with no evidence of disease were followed up for at least 3years were evaluated. Each of 15 quality of life domains with a total of ten points were given for a quality of life score. Results: There was no significant difference in the physical-mental adaptation index such as general health and mental health between the laryngectomees and control group(p>0.05). However, social adaptation index such as social activity, occupational status and economic status for laryngectomees were significantly lower with 2.3, 3.5, and 4.4 points compared to control group with 8.5, 7.6, and 7.1 points respectively(p<0.05). Conclusion : Vocational and social rehabilitation should be emphasized with highest priority for improving their economic status and thus improving their quality of life.

• Journal of Preventive Medicine and Public Health
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• v.57 no.2
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• pp.138-147
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• 2024

Objectives: Fine particulate matter pollution has emerged as a significant life-threatening issue in Thailand. Recognizing the importance of environmental health literacy (EHL) in disease prevention is crucial for protecting public health. This study investigated EHL levels and aimed to identify associated factors among village health volunteers (VHVs) in the upper northern region of Thailand. Methods: A cross-sectional study was conducted to collect data from 710 VHVs using the EHL assessment tool developed by the Department of Health, Thailand. Results: The overall EHL score was moderate (mean, 3.28 out of a possible 5.0), with the highest and lowest domain-specific mean score for the ability to make decisions (3.52) and the ability to access (3.03). Multiple linear regression revealed that the factors associated with EHL score were area of residence (urban areas in Chiang Mai: B=0.254; urban areas in Lampang: B=0.274; and rural areas in Lampang: B=0.250 compared to rural areas in Chiang Mai), higher education levels (senior high school: B=0.212; diploma/high vocational certificate: B=0.350; bachelor's degree or above: B=0.528 compared to elementary school or lower), having annual health checkups compared to not having annual health check-ups (B=0.142), monthly family income (B=0.004), and individuals frequently facing air pollution issues around their residence (B=0.199) compared to those who reported no such issues. Conclusions: The VHVs exhibited moderate EHL associated with residence area, education, health check-ups, family income, and residential air pollution. Considering these factors is vital for enhancing VHVs' EHL through strategic interventions.