• Journal of Genetic Medicine
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• 제10권1호
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• pp.13-19
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• 2013

Retinitis pigmentosa (RP) is the most common hereditary retinal disorder and is characterized by progressive retinal degeneration and decline in vision. RP comprises a heterogeneous group of disorders caused by various genetic variants. Since the first discovery of the causal mutation in the RHO gene using positional cloning, numerous mutations have been detected in more than 60 loci and 50 genes. However, causal genes have not been discovered in about 50% of cases. We attempt here to review the strategies to identify causal alleles of retinitis pigmentosa. These include conventional methods as well as state-of-the-art technologies based on next-generation sequencing.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.159-164
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• 2004

Blepharoptosis is the state that upper eyelid sagges, palpebal fissure becomes narrow due to disorder of a levator palpebrae superioris or innervation. It affects not only the physical vision but also mental shrink. In the view of oriental medicine, there are various causes, among them mainly cause is the deficiency of spleen Gi. The other hand, we treated a patient who suffered from blepharoptosis(with headache, exotropia, dizziness) differentiate from stagnation of Gi(energy) and blood stasis with Sungihwalhyeoltang(順氣活血湯) mostly. After about 40days of Sungihwalhyeoltang(順氣活血湯) centered treatment, acupunture, we observed an improvement Based on this experience, it is considered that stagnation of Gi(energy) and blood stasis can bring about blepharoptosis.

• 한국융합학회논문지
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• 제12권2호
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• pp.113-120
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• 2021

본 연구는 시각적인 장애를 호소하는 ADHD로 진단받은 아동의 유형별 시각 기능의 특징을 확인하고자 하였다. 연구 대상자는 ADHD로 진단받은 아동 49명으로 시각기능이 정상범위에서 벗어난 경우이다. Korean-ADHD Rating Scale을 이용하여 ADHD 유형을 알아보았고 시각기능 검사를 통해 시각 기능의 문제를 알아보았다. 시각의 문제를 가지고 있는 ADHD 아동들은 부주의 유형(69.4%)이 가장 많았으며 시력은 좋지만 시각 기능 문제가 드러난 경우도 50% 정도 되었다. 주의력결핍 유형에서 근시 관련 시각장애, 과잉활동형 유형에서 난시 관련된 시각장애가 높게 나타났다. 버전스 기능 장애에서는 폭주부족이 가장 많았으며 유형별 차이는 나타나지 않았다. ADHD 아동의 유형별 시각장애의 특성은 차이가 나타나므로 시각 기능 장애의 검사와 선별을 통해 아동의 문제행동에 접근하는 것이 필요하다.

• 인터넷정보학회논문지
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• 제11권1호
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• pp.77-84
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• 2010

모국어나 외국어를 습득할 때 언어 처리의 '속도' 및 '정확도'가 적절하지 않으면 언어발달이 지연되거나 외국어 학습에 어려움을 보이게 되며, 실제 이를 통한 의사소통 상황에서 어려움을 겪게 된다. 따라서, 언어 학습 능력을 평가할 때 단순히 언어 처리의 정확도만이 아닌 '속도'와 '정확도'를 동시에 측정하는 것이 중요하며, 학습에 있어서도 이러한 처리의 효율성을 향상 시키는 것이 필요하다. 우리는 음성 및 시각 자극에 대한 '반응속도 측정기 플랫폼'을 개발함으로써 효율적인 언어 수행 능력을 평가하고 학습 향상에 적용하고자 하였다. 이 글에서는 먼저 이 플랫폼의 구성 및 내용 그리고 온라인 컨텐츠 구성 등의 개발 과정에 대하여 제시하였다. 또한, 이 플랫폼의 실제 적용 가능성을 검토하기 위하여 10명의 성인에게 '청각', '시각' 그리고 '시청각'의 3 가지 자극 조건을 제시하고, 각 조건에서 5회 이상 자극에 반응을 보이도록 하였다. 그리고 1회와 5회 반응의 반응 속도 및 정확도를 측정하여 비교하여 보았다. 이러한 결과 이 플랫폼이 정도의 차이는 있으나 자극의 종류에 상관없이 보다 빠르고 정확하게 언어를 처리할 수 있도록 능력을 향상시키는데 도움을 주고 있음을 알 수 있었다.

• Biomolecules & Therapeutics
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• 제11권4호
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• pp.249-256
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• 2003

Pyroligneous liquid(PL) is produced by carbonizing Oak in 350-40$0^{\circ}C$. It is traditionally used for treating stress-related disorder, hepatic disease, immune disorder, G-I disorder and inflammatory disease. The aim of this study is to investigate anti-stress effects of PL. The experiments were performed with the use of young(9 weeks of age) male rats of SD strain and the male ICR mice (20-25 g). Animals of the normal group were not exposed to any stress and the control group were exposed to stress. The rats of the Ginseng, diazepam(BZ) and PL supplementary group were orally administered once a day 100 g of Ginseng extract-kg body weight, 5 mg of BZ/kg body weight and 1 ml of PL100 g body weight and then exposed to stress. The mice of the Ginseng, BZ and PL supplementary group were given water containing 100 g of Ginseng extract/100 ml potable water, 5 mg of BZ/kg 100 ml of drinking water and 10 ml of PL/100 ml of drinking water and exposed to stress. Animals were given materials for 7 days after stabilizing them, and then were given supplementary materials for 5 days with stress. They were stressed by immobilization for 30 minutes and then the animals were exposed to electroshocks for 5 minutes. We recorded stress-related behavioral changes of experimental animals by stressing them using the Etho-vision system and measured the levels of corticosterone in blood While stress suppressed locomotor activity of animals, PL-supplementation partially blocked the stress effect of locomotion in rats and mice, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling and rearing activity in rats and freezing, grooming, tailing and rearing in mice. The staying time of stressed rats and mice in open area decreased and in closed area it increased relatively in elevated plus maze test. However, these changes also partially were blocked by PL-supplementation. PL-supplementation decreased levels of blood corticosterone increased by stress in rats. These results suggest that PL protects partially the living organism from stress attack in some cases.

• 대한임상독성학회지
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• 제4권1호
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• pp.52-54
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• 2006

Datura stramonium is a wild growing plant, consumption of which can result in severe toxicity. It contains a variety alkaloids include atropine, hyoscamine, and scopolamine that can all cause anticholonergic poisoning. It has been use of herb medicine in Korea. Side effects from ingesting Datura stramonium include dry mouth, blurred vision, photophobia, and may be followed by hyperthermia, confusion, agitation, hallucination, and aggressive behavior. In severe toxicity, it can cause seizure, coma, life-threatening arrhythmia, and death. We experienced one patient who developed stupor mentality caused by Datura stramonium. Severe presentation, especially mental change of Datura stramonium should draw attention. Poisoning associated with Datura stramonium can be prevented through educational public health program.

• Molecules and Cells
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• 제39권10호
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• pp.750-755
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• 2016

Although innate color preference of motile organisms may provide clues to behavioral biases, it has remained a longstanding question. In this study, we investigated innate color preference of zebrafish larvae. A cross maze with different color sleeves around each arm was used for the color preference test (R; red, G; green, B; blue, Y; yellow). The findings showed that 5 dpf zebrafish larvae preferred blue over other colors (B > R > G > Y). To study innate color recognition further, tyrosinase mutants were generated using CRISPR/Cas9 system. As a model for oculocutaneous albinism (OCA) and color vision impairment, tyrosinase mutants demonstrated diminished color sensation, indicated mainly by hypopigmentation of the retinal pigment epithelium (RPE). Due to its relative simplicity and ease, color preference screening using zebrafish larvae is suitable for high-throughput screening applications. This system may potentially be applied to the analysis of drug effects on larval behavior or the detection of sensory deficits in neurological disorder models, such as autism-related disorders, using mutant larvae generated by the CRISPR/Cas9 technique.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권8호
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• pp.3820-3841
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• 2018

Most of the accidents occur due to drowsiness while driving, avoiding road signs and due to driver's distraction. Driver's distraction depends on various factors which include talking with passengers while driving, mood disorder, nervousness, anger, over-excitement, anxiety, loud music, illness, fatigue and different driver's head rotations due to change in yaw, pitch and roll angle. The contribution of this paper is two-fold. Firstly, a data set is generated for conducting different experiments on driver's distraction. Secondly, novel approaches are presented that use features based on facial points; especially the features computed using motion vectors and interpolation to detect a special type of driver's distraction, i.e., driver's head rotation due to change in yaw angle. These facial points are detected by Active Shape Model (ASM) and Boosted Regression with Markov Networks (BoRMaN). Various types of classifiers are trained and tested on different frames to decide about a driver's distraction. These approaches are also scale invariant. The results show that the approach that uses the novel ideas of motion vectors and interpolation outperforms other approaches in detection of driver's head rotation. We are able to achieve a percentage accuracy of 98.45 using Neural Network.

• 대한가정학회지
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• 제46권8호
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• pp.17-26
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• 2008

The purpose of this study was to identify the aesthetic characteristics of modern fashion design use with a particular focus on transparency, and to help create future vision and feature. As part of the methodology for this study, I examined the concept of transparency, its characteristics and how it was expressed through art, architecture and other designs using literature research. Furthermore, I performed justifiable analysis on modern fashion design which used transparency from the 1990s till present. The following concepts were deciphered from information: Firstly, the concept of purity was highlighted. The emphasis here was to enhance the body's natural beauty with simple silhouettes that do not restrict its curves, using light materials such as clear vinyl, semi-clear materials or thin chiffon. Secondly, to express sensuality by exposing the body's curves with tight wrapping using clear materials, or with indirect and symbolic see-through techniques using contrasting clear, semi-clear and opaque materials. Thirdly, to express futurism through cyber and electronic images using high tech or shiny materials such as metal or holograms. Mechanical movements or effects of light are also used. Fourthly, to express playful characteristic by promoting surprises and disharmony that contradict with traditional techniques. This is carried out by intentionally exaggerating certain portions of clothes through disorder elements or confusion, and unsymmetrical shapes which destruct the human body's normal form.

• 한국임상약학회지
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• 제29권2호
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• pp.133-137
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• 2019

Atorvastatin is one of the most widely prescribed medications for dyslipidemia treatment. In Korea, post combined therapy with ezetimibe, a 73-year-old woman was reported by a community pharmacy to have experienced visual field defect, which recovered after drug discontinuation. She had never experienced this symptom before, and several studies have reported an association between use of statins and visual disorders such as blurred vision, diplopia, and cataract. Blockage of cholesterol accumulation, oxidative stress, or myopathy is expected to be a cause of this symptom. Naranjo scale, Korean causality assessment algorithm (Ver.2), and World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria were the three tools used to determine causality between the visual disorder and atorvastatin. The results represent 'probable', 'certain', and 'probable/likely' causality, respectively. Our results, in combination with a review of literature, indicate that ocular adverse effects are highly likely related to atorvastatin.