• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2002년도 춘계학술대회논문집
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• pp.229-234
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• 2002

Immune system is an evolutionary biological system to protect Innumerable foreign materials such as virus, germ cell, and et cetera. Immune algorithm is the modeling of this system'response that has adaptation and reliableness when disturbance occur. In this paper, immune algorithm controller was proposed to control four wheels steering(4ws) Automated Guided vehicle(AGV) in container yard. And then the simulation result was analysed and compared with the results of NN-PID controller.

• 한국지능시스템학회논문지
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• 제11권4호
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• pp.359-365
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• 2001

본 논문에서는 바이러스-진화 유전 알고리즘에 기반한 퍼지 기저 함수 확장을 이용한 표적 추적 시스템의 설계 방법을 제안한다. 일반적으로 표적 추적의 목적은 센서로부터 얻어진 표적의 과거 위치에 기반하여, 미래에 대한 표적의 궤적을 추정하는 것이다. 확장 칼만 필터와 같은 전통적이고 수학적인 비선형 필터링 기법에서 강한 비선형성은 시스템의 성능을 저하시킬 수 있다. 이러한 비선형 필터링 기법의 장점을 결합한다. 제안된 방법에서, 확장 칼만 필터의 파라미터로 학습 데이터를 구성하고, 강한 근사화 능력을 가지는 퍼지 기저 함수에 유전 알고리즘의 유전적 다양성 상실로 이한 조기 수렴을 방지하는 바이러스-진화 유전 알고리즘을 결합하여, 파라미터와 규칙 수를 동시에 동정시킴으로써 확장 칼만 필터의 오차를 보정한다. 마지막으로, 제안된 방법은 3차원 상의 모의 실험을 통해 그 성능이 입증된다.

• 한국임상수의학회지
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• 제27권4호
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• pp.421-426
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• 2010

In view of free from bluetongue (BT) in the domestic cattle population in Korea, the key of quarantine testing for BT virus (BTV) infection is detection of cattle previously exposed to the virus. The objective of this study was to estimate the probability of detecting a cattle infected with BTV using a stochastic modeling analysis of existing quarantine testing data. Three testing scenarios were considered in this study: serological testing of all animals in all imported lots (scenario 1), serological testing of a sample of cattle from all imported lots (scenario 2), and serological testing of 50% of imported lots (scenario 3). In scenario 2 and 3, it was assumed that cattle were sampled (sample size) within each lot to detect 5% of the cattle in each lot with a 95% confidence, taking into account diagnostic sensitivity of the ELISA (enzyme-linked immunosorbent assay). The model output was the total number of BTV-infected cattle and the prevalence of BTV infection in imported cattle from the US, Australia, Canada and Japan. Compared to the scenario 1, the probability of detecting a BTV-infected cattle was estimated to be 19% and 1.6% in scenario 2 and 3, respectively. Furthermore, the analyses showed a 95% confidence that BTV prevalence was less or equal to $9.7{\times}10^{-4}$ (median = $1.5{\times}10^{-5}$), indicating that, for the scenario 2 and 3 with serological testing for a sample of cattle, the risk of introducing an exotic strain of BTV into Korea through the importation of live cattle would not be acceptable.

• 한국농공학회논문집
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• 제53권1호
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• pp.29-36
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• 2011

HPAI (High pathogenic avian influenza) which is a disease legally designated as an epidemic generally shows rapid spread of disease resulting in high mortality rate as well as severe economic damages. Because Korea is contiguous with China and southeast Asia where HPAI have occurred frequently, there is a high risk for HPAI outbreak. A prompt treatment against epidemics is most important for prevention of disease spread. The spread of HPAI should be considered by both direct and indirect contact as well as various spread factors including airborne spread. There are high risk of rapid propagation of HPAI flowing through the air because of collective farms mostly in Korea. Field experiments for the mechanism of disease spread have limitations such as unstable weather condition and difficulties in maintaining experimental conditions. In this study, therefore, computational fluid dynamics which has been actively used for mass transfer modeling were adapted. Korea has complex terrains and many livestock farms are located in the mountain regions. GIS numerical map was used to estimate spreads of virus attached aerosol by means of designing three dimensional complicated geometry including farm location, road network, related facilities. This can be used as back data in order to take preventive measures against HPAI occurrence and spread.

• 한국임상수의학회지
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• 제36권1호
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• pp.23-29
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• 2019

While research findings suggest that the highly pathogenic avian influenza (HPAI) is the leading cause of economic loss in Korean poultry industry with an estimated cumulative impact of $909 million since 2003, identifying the environmental and anthropogenic risk factors involved remains a challenge. The objective of this study was to identify areas at high risk for potential HPAI outbreaks according to the likelihood of HPAI virus detection in wild birds. This study integrates spatial information regarding HPAI surveillance with relevant demographic and environmental factors collected between 2003 and 2018. The Maximum Entropy (Maxent) species distribution modeling with presence-only data was used to model the spatial risk of HPAI virus. We used historical data on HPAI occurrence in wild birds during the period 2003-2018, collected by the National Quarantine Inspection Agency of Korea. The database contains a total of 1,065 HPAI cases (farms) tied to 168 unique locations for wild birds. Among the environmental variables, the most effective predictors of the potential distribution of HPAI in wild birds were (in order of importance) altitude, number of HPAI outbreaks at farm-level, daily amount of manure processed and number of wild birds migrated into Korea. The area under the receiver operating characteristic curve for the 10 Maxent replicate runs of the model with twelve variables was 0.855 with a standard deviation of 0.012 which indicates that the model performance was excellent. Results revealed that geographic area at risk of HPAI is heterogeneously distributed throughout the country with higher likelihood in the west and coastal areas. The results may help biosecurity authority to design risk-based surveillance and implementation of control interventions optimized for the areas at highest risk of HPAI outbreak potentials.

• Journal of Veterinary Science
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• 제21권2호
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• pp.26.1-26.14
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• 2020

Pancreatic ductal adenocarcinoma is a lethal cancer type that is associated with multiple gene mutations in somatic cells. Genetically engineered mouse is hardly applicable for developing a pancreatic cancer model, and the xenograft model poses a limitation in the reflection of early stage pancreatic cancer. Thus, in vivo somatic cell gene engineering with clustered regularly interspaced short palindromic repeats is drawing increasing attention for generating an animal model of pancreatic cancer. In this study, we selected Kras, Trp53, Ink4a, Smad4, and Brca2 as target genes, and applied Campylobacter jejuni Cas9 (CjCas9) and Streptococcus pyogens Cas9 (SpCas9) for developing pancreatic cancer using adeno associated virus (AAV) transduction. After confirming multifocal and diffuse transduction of AAV2, we generated SpCas9 overexpression mice, which exhibited high double-strand DNA breakage (DSB) in target genes and pancreatic intraepithelial neoplasia (PanIN) lesions with two AAV transductions; however, wild-type (WT) mice with three AAV transductions did not develop PanIN. Furthermore, small-sized Cjcas9 was applied to WT mice with two AAV system, which, in addition, developed high extensive DSB and PanIN lesions. Histological changes and expression of cancer markers such as Ki67, cytokeratin, Mucin5a, alpha smooth muscle actin in duct and islet cells were observed. In addition, the study revealed several findings such as 1) multiple DSB potential of AAV-CjCas9, 2) peri-ductal lymphocyte infiltration, 3) multi-focal cancer marker expression, and 4) requirement of > 12 months for initiation of PanIN in AAV mediated targeting. In this study, we present a useful tool for in vivo cancer modeling that would be applicable for other disease models as well.

• Journal of Preventive Medicine and Public Health
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• 제43권2호
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• pp.109-116
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• 2010

Objectives: The pandemic of novel influenza A (H1N1) virus has required decision-makers to act in the face of the substantial uncertainties. In this study, we evaluated the potential impact of the pandemic response strategies in the Republic of Korea using a mathematical model. Methods: We developed a deterministic model of a pandemic (H1N1) 2009 in a structured population using the demographic data from the Korean population and the epidemiological feature of the pandemic (H1N1) 2009. To estimate the parameter values for the deterministic model, we used the available data from the previous studies on pandemic influenza. The pandemic response strategies of the Republic of Korea for novel influenza A (H1N1) virus such as school closure, mass vaccination (70% of population in 30 days), and a policy for anti-viral drug (treatment or prophylaxis) were applied to the deterministic model. Results: The effect of two-week school closure on the attack rate was low regardless of the timing of the intervention. The earlier vaccination showed the effect of greater delays in reaching the peak of outbreaks. When it was no vaccination, vaccination at initiation of outbreak, vaccination 90 days after the initiation of outbreak and vaccination at the epidemic peak point, the total number of clinical cases for 400 days were 20.8 million, 4.4 million, 4.7 million and 12.6 million, respectively. The pandemic response strategies of the Republic of Korea delayed the peak of outbreaks (about 40 days) and decreased the number of cumulative clinical cases (8 million). Conclusions: Rapid vaccination was the most important factor to control the spread of pandemic influenza, and the response strategies of the Republic of Korea were shown to delay the spread of pandemic influenza in this deterministic model.

• 융합보안논문지
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• 제23권5호
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• pp.209-221
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• 2023

2019년 12월 코로나19 바이러스의 급격한 확산으로 인해 대면 중심의 근무환경이 비대면 중심의 근무환경으로 급격히 전환되었다. 그러나 방산업체의 경우 군과 관련된 기술을 다루는 조직으로 망분리 정책을 적용하고 있어 비대면 적용에 제한이 많은 상태이다. 비대면 근무는 전세계적인 변화이고 향후 급변하는 환경을 고려했을 때 방산업체도 적용해야 하는 시급한 과제이다. 때문에 현재 방산업체가 비대면 근무를 시행하기 위해서는 VPN, VDI, 망연동시스템 등은 필수 요소로 적용되어야 한다. 결국 필연적으로 일부 접점이 발생할 수 밖에 없는데 이로 인해 보안취약점이 증가할 것이며 적극적인 보안관리가 중요하다. 이에 본 논문에서는 미국의 MITER에서 사이버 공격을 체계적으로 탐지하고 대응하기 위해 주기적으로 발표하고 있는 MITRE ATT&CK Framework의 공격전술을 기반으로 공격유형을 선정, 위협을 분석하고 STRIDE 위협 모델링을 적용하여 보안위협을 분류, 구체적인 보안 요구사항을 제시하고자 한다.

• 융합보안논문지
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• 제14권5호
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• pp.37-47
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• 2014

악성코드 중 가장 많은 비율을 차지한 것은 트로이 목마이며, 트로이 목마의 경우 그 자체로 피해를 주는 형태가 주종을 이루었지만, 최근에는 백도어 방식으로 사용자 정보를 몰래 빼오는 형태가 많아지고 있으며, 트로이 목마의 특성을 갖고 있는 웜이나 바이러스가 증가하고 있는 추세이다. 웜의 확산 특징을 분석하기 위한 모델링 기법들이 제시되었지만 거시적인 분석만 가능하였고 특정 바이러스, 악성코드에 대해 예측하기는 한계점이 있다. 따라서 본 논문에서는 과거의 Trojan 데이터를 활용하여 미래의 Trojan 악성코드의 발생을 예측 할 수 있는 ESP모델을 제시하였다. 이 모델을 적용하여 얻어진 예측 값을 마코프 체인과 비교한 결과 제안한 모델이 기존 발생한 실제 빈도수와 유사한 값을 나타냄을 알 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제34권8호
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• pp.2466-2472
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• 2013

Human immunodeficiency virus type-1 (HIV-1) is a causative agent of Acquired immunodeficiency syndrome (AIDS), which has affected a large population of the world. Viral envelope glycoprotein (gp120) is an intrinsic protein for HIV-1 to enter into human host cells. Molecular docking guided molecular dynamics (MD) simulation was performed to explore the interaction mechanism of heterobiaryl derivative with gp120. MD simulation result of inhibitor-gp120 complex demonstrated stability. Our MD simulation results are consistent with most of the previous mutational and modeling studies. Inhibitor has an interaction with the CD4 binding region. Van der Waals interaction between inhibitor and Val255, Thr257, Asn425, Met426 and Trp427 were important. This preliminary MD model could be useful in exploiting heterobiaryl-gp120 interaction in greater detail, and will likely to shed lights for further utilization in the development of more potent inhibitors.