• Biomolecules & Therapeutics
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• 제28권4호
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• pp.311-319
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• 2020

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging viral disease with fatal outcomes. However, no MERS-CoV-specific treatment is commercially available. Given the absence of previous structure-based drug discovery studies targeting MERS-CoV fusion proteins, this set of compounds is considered the first generation of MERS-CoV small molecule fusion inhibitors. After a virtual screening campaign of 1.56 million compounds followed by cell-cell fusion assay and MERS-CoV plaques inhibition assay, three new compounds were identified. Compound numbers 22, 73, and 74 showed IC₅₀ values of 12.6, 21.8, and 11.12 µM, respectively, and were most effective at the onset of spike-receptor interactions. The compounds exhibited safe profiles against Human embryonic kidney cells 293 at a concentration of 20 µM with no observed toxicity in Vero cells at 10 µM. The experimental results are accompanied with predicted favorable pharmacokinetic descriptors and drug-likeness parameters. In conclusion, this study provides the first generation of MERS-CoV fusion inhibitors with potencies in the low micromolar range.

• 인터넷정보학회논문지
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• 제7권6호
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• pp.51-62
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• 2006

기존의 다른 어떤 종류의 게임보다도 큰 부하와 거대한 하나의 가상월드가 MMORPG(Massively Multiplayer Online Role-Playing Game)의 중요한 특징이다. 이러한 Seamless 환경에서는, 독립된 게임 서버들이 관리하는 하위의 공간들을 모아 하나의 거대한 가상 월드로 구축한다. 게임 개발자들의 노력에도 불구하고 게이머들은 여전히 클라이언트와 서버, 필드 서버들 간의 상호작용에서 비롯된 과다한 메시지 트래픽에 대해 불만을 가지고 있다. 본 논문에서는 메시지 트래픽을 줄이기 위해 MigAgent를 이용한 새로운 게임 서버 구조를 제안한다. 일반적으로 PC(Player Character)가 다른 필드 서버로 이동할 때 발생하는 메시지 트래픽이 최고조에 이른다. MigAgent는 이런 PC들을 처리하고 예기치 못한 상황에 대처하기 위한 에이전트 역할을 수행한다. 관심영역과 인접 셀의 크기 비율에 따라 그 효과를 분석함으로써 이 시스템의 효과를 분석한다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2007년도 제28회 춘계학술대회논문집
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• pp.250-257
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• 2007

항공기용 엔진은 설계 개발 단계에서 성능, 신뢰성, 안정성, 수명을 판단하는 시험에 엄청난 시간과 비용이 든다. 가상 엔진의 "Numerical Test Cell" 시험은 다분야 연계 해석을 통하여 하드웨어의 개발에 필요한 시간과 비용을 줄일 수 있다. 본 논문에서는 미국과 유럽에서의 전체 엔진 시뮬레이션 프로그램의 개발 활동을 소개한다. 미국의 NASA Glenn 연구소는 기존의 코드들을 결합하고 기능을 개선하여 NPSS를 개발하는 연구를 이끌고 있으며, 유럽에서는 대학, 연구소, 기업체로 구성된 VIVACE 컨소시움이 각 기관의 프로그램을 통합하여 PROOSIS를 개발하고 있다. 아울러 현재의 상황에 대한 고찰을 통하여 국내 개발의 가능성을 살펴보았다.

• 한국정보처리학회논문지
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• 제2권3호
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• pp.397-405
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• 1995

생산 공정에서 공동의 작업 범위 지역에 위치한 제어 기기들에 대한 보다 효율적인 운영과 자원을 공유하기 위하여 네트워크 기술이 적용되어 운영되고 있다. 본 논문에서는 네트워크 운영 계층의 실장 규격을 CIM에서 공동 제조 영역으로 제안한 cell혹은 group을 위한 MAP 규격의 응용 계층인 MMS로 선정하였다. MMS는 통신 기능의 추상화된 메세지로 특정 디바이스를 고려하지 않으므로,제조 공정의 단위 제어 기기를 운영하기 위하여서는 특정한 메세지 규격을 정의하여야 한다. 이러한 문제를 해결하기 위하여 단위 제어 기기별 컴패니언 규격을 적용하여 추상화된 객체인 가상제조 기기 (VMD)를 설계하고 이를 군관리 모델 시스템에서 운영하였다. 군관리 운영에서는 군관리 시스템과 단위 제어 기간의 통신은 VMD와 설계 제어 기기간의 매핑을 수행하므로써 운영할 수 있다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제11권2호
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• pp.121-129
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• 2011

It is progressing as new advents and remarkable developments of mobile device every year. On the upper line reason, NAND FLASH large density memory demands which can be stored into portable devices have been dramatically increasing. Therefore, the cell size of the NAND Flash memory has been scaled down by merely 50% and has been doubling density each per year. [1] However, side effects have arisen the cell distribution and reliability characteristics related to coupling interference, channel disturbance, floating gate electron retention, write-erase cycling owing to shrinking around 20nm technology. Also, FLASH controller to manage shrink effect leads to speed and current issues. In this paper, It will be introduced to solve cycling, retention and fail bit problems of sub-deep micron shrink such as Virtual negative read used in moving read, randomization. The characteristics of retention, cycling and program performance have 3 K per 1 year and 12.7 MB/s respectively. And device size is 179.32 $mm^2$ (16.79 mm ${\times}$ 10.68 mm) in 3 metal 26 nm CMOS.

• Toxicological Research
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• 제35권4호
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• pp.295-301
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• 2019

In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 diverse chemicals estimated by modeling virtual oral administration in rats. To ensure that a broad range of chemical structures is present among the selected substances, the properties described by 196 chemical descriptors in a chemoinformatics tool were calculated for 50,000 randomly selected molecules in the original chemical space. To allow visualization, the resulting chemical space was projected onto a two-dimensional plane using generative topographic mapping. The calculated absorbance rates of the chemicals based on cell permeability studies were found to be inversely correlated to the no-observed-effect levels for hepatoxicity after oral administration, as obtained from the Hazard Evaluation Support System Integrated Platform in Japan (r = -0.88, p < 0.01, n = 27). The maximum plasma concentrations and the areas under the concentration-time curves (AUC) of a varied selection of chemicals were estimated using two different methods: simple one-compartment models (i.e., high-throughput toxicokinetic models) and simplified physiologically based pharmacokinetic (PBPK) modeling consisting of chemical receptor (gut), metabolizing (liver), and central (main) compartments. The results obtained from the two methods were consistent. Although the maximum concentrations and AUC values of the 53 chemicals roughly correlated in the liver and plasma, inconsistencies were apparent between empirically measured concentrations and the PBPK-modeled levels. The lowest-observed-effect levels and the virtual hepatic AUC values obtained using PBPK models were inversely correlated (r = -0.78, p < 0.05, n = 7). The present simplified PBPK models could estimate the relationships between hepatic/plasma concentrations and oral doses of general chemicals using both forward and reverse dosimetry. These methods are therefore valuable for estimating hepatotoxicity.

• 문화기술의 융합
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• 제9권1호
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• pp.191-197
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• 2023

본 연구의 목적은 반도체 생산라인-클린룸에 활용할 수 있는 가상현실 실습 콘텐츠 제작 설계, 제작과정에 관한상 교육환경을 제공을 목표로 진행하였다. 사용자는 본 과정을 통하여 클린룸 입장 전후의 절차적 지식과 함께, 반도체 솔라셀 주요 제조설비를 직접 체험하는 등 실제에 가까운 체험을 통한 실제적 지식을 습득할 수 있다. 특히 반도체 및 솔라셀 제조공정에 필요한 체험 콘텐츠와 클린룸 입실 절차 체험 콘텐츠 환경 조성하여 사용자에게 실제에 가까운 몰입 경험을 제공하며, 이는 교육의 몰입감, 실재감, 교육의 비용, 효율성 및 교육 만족도 향상을 기대 하였다. 이러한 실감 콘텐츠의 몰입감, 상호작용, 지능화 등 그 특징에 따라 고위험(Dangerous), 체험불가(Impossible), 고대가성(Counter-productive), 고비용(Expensive) 분야에 활발히 적용될 것으로 예상되며, 실감 콘텐츠 학습자가 학습내용에 몰입하게 하고, 주도적/능동적 학습을 유도함은 물론 학습내용을 체화시켜 교육효과 증진 부문에 긍정적인 성과를 기대 하게되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4147-4156
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• 2015

Lung cancer is a serious health problem and leading cause of death worldwide due to its high incidence and mortality. More than 80% of lung cancers feature a non-small cell histology. Over few decades, systemic chemotherapy and surgery are the only treatment options in this type of tumor but due to their limited efficacy and overall poor survival of patients, there is an urge to develop newer therapeutic strategies which circumvent the problems. Enhanced knowledge of translational science and molecular biology have revealed that lung tumors carry diverse driver gene mutations and adopt different intracellular pathways leading to carcinogenesis. Hence, the development of targeted agents against molecular subgroups harboring critical mutations is an attractive approach for therapeutic treatment. Targeted therapies are clearly more preferred nowadays over systemic therapies because they target tumor specific molecules resulting with enhanced activity and reduced toxicity to normal tissues. Thus, this review encompasses comprehensive updates on targeted therapies for the driver mutations in non-small cell lung cancer (NSCLC) and the potential challenges of acquired drug resistance faced i n the field of targeted therapy along with the imminent newer treatment modalities against lung cancer.

• BMB Reports
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• 제37권6호
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• pp.671-675
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• 2004

The expression and clinicopathological significance of Quox-1 gene was studied in oral squamous cell carcinoma (OSCC). Immunocytochemistry and western blot analysis were used to examine the different expressions of Quox-1 protein in 114 OSCC specimens, 34 oral epithelial dysplasia specimens, and 16 normal oral mucosa specimens. RT-PCR and virtual Northern Blot were also used to examine the expression of Quox-1 mRNA. It was found that Quox-1 was not expressed in normal epithelium. However, as dysplastic lesions progressed Quox-1 expression increased (p < 0.01), and Quox-1 expression was not significantly different between severe dysplasia and highly differentiated OSCCs (p > 0.05). As the degree of differentiation decreased, Quox-1 positivity increased in OSCC (p < 0.01), and the rate of Quox-1 (81.58%) positivity in OSCC was higher than that in normal oral mucosa (p < 0.01). Our findings imply that the positive expression of Quox-1 is correlated with the histological classification of OSCCs. Thus, the expression of Quox-1 in OSCC may serve as a significant predicting factor of proliferative status and malignant degree, and it may also be a biological detection marker of oral mucosas initial cancer and of OSCC.

• 한국통신학회논문지
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• 제41권12호
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• pp.1721-1735
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• 2016

Power-efficient base station (BS) operation is one of the important issues in future green cellular networks. Previously well-known BS operation schemes, the cell zooming scheme and the cell wilting and blossoming scheme, require tight cooperation between cells in cellular networks. With the previous schemes, the non-cooperative BSs of a serving cell and neighboring cells could cause coverage holes between the cells, thereby seriously degrading the quality of service as well as the power saving efficiency of the cellular networks. In this paper, we propose a novel power-efficient BS operation scheme for green downlink heterogeneous cellular networks, in which the networks virtually adjust the coverage of a serving macrocell (SM) and neighboring macrocells (NMs) without adjusting the transmission power of the BSs when the SM is lightly loaded, and the networks turn off the BS of the SM when none of active users are associated with the SM. Simulation results show that our proposed scheme significantly improves the power saving efficiency without degrading the quality of service (e.g., system throughput) of a downlink heterogeneous LTE network and outperforms the previous schemes in terms of system throughput and power saving efficiency. In particular, with the proposed scheme, macrocells are able to operate independently without the cooperation of a SM and NMs for green heterogeneous cellular networks.