• Journal of Environmental Impact Assessment
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• v.32 no.5
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• pp.318-337
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• 2023

This study utilizes system dynamics to examine the effects of fine dust reduction policies on PM10 concentration and health. System dynamics has the advantage of modeling the dynamic and circular relationship between PM₁₀ emission sources, reduction policies, PM₁₀ concentration, and health effect. The study created policy scenarios for Korea's representative fine dust reduction policies - industrial PM₁₀ emission control, diesel vehicle regulation, expansion of electric vehicles, and expansion of parks and green areas - and compared the results with the 2030 baseline if the current trend is maintained. The analysis showed that the policy of supporting electric vehicles reduced PM₁₀ concentration by 0.21 ㎍/m³ and reduced the number of people with circulatory diseases by 494, and the effect was evenly distributed across the country. The industrial emissions regulation scenario resulted in the highest PM₁₀ concentration reduction of 0.22 ㎍/m³, but had a lower reduction in the number of people affected (358) than the EV support strategy, which could be attributed to the fact that this policy had a particularly high PM₁₀ reduction effect in industrial areas such as Danyang-gun, Chungcheongbuk-do, and Sahagu, Busan. As a policy implication, this study suggests that it is necessary to apply fine dust policies tailored to the characteristics of local emission sources.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.17 no.5
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• pp.95-104
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• 2022

This study aims to find out the influence of the intolerance of uncertainty on entrepreneurial intention by focusing on the start-up support system awareness. While most of existing studies focused on the positive psychological variables and individual environmental characteristics influencing on the entrepreneurial intention, this study has taken a look at the influence of the intolerance of uncertainty as the psychological variable to the entrepreneurial intention to negatively act on the entrepreneurial intention. As a result of the analysis, the intolerance of uncertainty under the control of entrepreneurship and gender is shown to have the negative (-) influence on the entrepreneurial intention and has high level of recognition on the start-up support system perception, and the start-up support system perception is confirmed to have positive (+) influence on the entrepreneurial intention. And, it also indicates that, with respect to the influence of the intolerance of uncertainty on the entrepreneurial intention, the start-up support system perception has the partial medium effect. Following this result of the study, it provides following indications: First the existing studies on the entrepreneurial intention had not covered the intolerance of uncertainty but it is confirmed as the psychological variable with negative influence on the entrepreneurial intention. Second, it is feasible for the preliminary start-up businesses may turn the fear on start-up failure into positive entrepreneurial intention with the start-up support system perception as the leading vehicle. And, third, based on the result, the government should enhance the start-up support system perception even more by seeking ways of efficient publicity to enable more preliminary start-up businesses to participate in diverse start-up support policies. Lastly, it discusses the limitations of this study as well as proposal for ensuing study plans.

• Journal of Internet Computing and Services
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• v.25 no.1
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• pp.157-166
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• 2024

The Army TIGER System, which is being deployed to implement a future combat system, is expected to bring innovative changes to the army's combat methods and comabt execution capability such as mobility, networking and intelligence. To this end, the Army will introduce various systems using drones, robots, unmanned vehicles, AI(Artificial Intelligence), etc. and utilize them in combat. The use of various unmanned vehicles and AI is expected to result in the introduction of equipment with new technologies into the army and an increase in various types of transmitted information, i.e. data. However, currently in the military, there is an acceleration in research and combat experimentations on warfigthing options using Army TIGER forces system for specific functions. On the other hand, the current reality is that research on cyber threats measures targeting information systems related to the increasing number of unmanned systems, data production, and transmission from unmanned systems, as well as the establishment of cloud centers and AI command and control center driven by the new force systems, is not being pursued. Accordingly this paper analyzes the structure and characteristics of the Army TIGER force integration system and makes suggestions for necessity of building, available cyber defense solutions and Army TIGER integrated cyber protections system that can respond to cyber threats in the future.

• Journal of Internet Computing and Services
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• v.25 no.1
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• pp.147-155
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• 2024

Currently, the 4th Industrial Revolution, like other revolutions, is bringing great change and new life to humanity, and in particular, the demand for and use of drones, which can be applied by combining various technologies such as big data, artificial intelligence, and information and communications technology, is increasing. Recently, it has been widely used to carry out dangerous military operations and missions, such as the Russia-Ukraine war and North Korea's reconnaissance against South Korea, and as the demand for and use of drones increases, concerns about the safety and security of drones are growing. Currently, a variety of research is being conducted, such as detection of wireless communication abnormalities and sensor data abnormalities related to drones, but research on real-time detection of threats using radio frequency characteristic data is insufficient. Therefore, in this paper, we conduct a study to determine whether the characteristic data is normal or abnormal signal data by collecting radio frequency signal characteristic data generated while the drone communicates with the ground control system while performing a mission in a HITL(Hardware In The Loop) simulation environment similar to the real environment. proceeded. In addition, we propose an unsupervised learning-based threat detection system and optimal threshold that can detect threat signals in real time while a drone is performing a mission.

• The Journal of the Acoustical Society of Korea
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• v.26 no.7
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• pp.361-365
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• 2007

Aero-pulsation noise, generally caused by geometric asymmetry of a rotating device, is one of considerable sources of annoyance in passenger cars using the turbocharged diesel engine. Main source of this noise is the compressor wheel in the turbocharger system, and can be reduced by after-treatment devices such as silencers, but which may increase the manufacturing cost. More effective solution is to improve the geometric symmetry over all, or to control the quality of components by sorting out inferior ones. The latter is more simple and reasonable than the former in view of manufacturing. Thus, an appropriate discrimination method should be needed to evaluate aero-pulsation noise level at the production line. In this paper, we introduce the accurate method which can measure the noise level of aero-pulsation and also present its evaluation criteria. Besides verifying the reliability of a measurement system - a rig test system-, we analyze the correlation between the results from rig tests and those from vehicle tests. The gage R&R method is carried out to check the repeatability of measurements over 25 samples. From the result, we propose the standard specification which can discriminate inferior products from superior ones on the basis of aero-pulsation noise level.

• Herbal Formula Science
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• v.32 no.1
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• pp.63-82
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• 2024

Objective : Saengkankunbi-tang (SKT) is used as a traditional Korean herbal formula for treatment of liver diseases. We investigated the hepatoprotective effects of SKT plus Epimedium koreanum Nakai (EKE) against arachidonic acid (AA) + iron-mediated cytotoxicity in HepG2 cells and carbon tetrachloride (CCl₄)-mediated acute liver damage in mice. Methods : The cyto-protective effects of SKT + EKE were determined by MTT assay, western blot and fluorescence activated cell sorting analysis. In mice, blood biochemistry and western blot were assessed in CCl₄-induced acute hepatic damage. The animal groups included vehicle-treated control, CCl₄, SKT (200 mg/kg/day), EKE (100 mg/kg/day), SKT (200 mg/kg/day) + EKE (100 mg/kg/day) and silymarin (200 mg/kg/day). Results : In HepG2 cells, pretreatment with SKT + EKE significantly suppressed cytotoxicity induced by AA + iron and reduced the expression of proteins related to apoptosis. In addition, pretreatment with SKT + EKE significantly prevented the increase in H₂O₂ production, GSH depletion, and lower mitochondrial membrane potential induced by AA + iron. In CCl₄-induced liver damage mice, the administration of SKT + EKE prevented the liver damage by inhibition of hepatocyte damage and expression of apoptosis proteins in liver. More importantly, in vitro and in vivo assay, SKT + EKE showed significant effect compare with SKT alone or EKE alone in all parameters. Conclusions : These results indicated that SKT + EKE could protect against oxidative stress-induced liver damage, and SKT + EKE is more effective than SKT alone or EKE alone.

• Journal of Korean Medicine for Obesity Research
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• v.24 no.1
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• pp.87-93
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• 2024

Objectives: Obesity is a globally prevalent public health issue. Hence, there is a need for the development of safer and more effective anti-obesity drugs. Lythrum salicaria, a traditional medicinal herb used for centuries, has been reported to improve lipid metabolism and fat accumulation. It also has a low toxicity profile. Therefore, its potential as a functional ingredient in health functional foods needs to be evaluated. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 90 participants will be randomly assigned to either the experimental or control group. Each subject will orally receive L. salicaria extract (1,350 mg/day) (500 mg L. salicaria+850 mg lactose as vehicle) or lactose (1,350 mg/day) as a hard capsule formula for 84 days (12 weeks). The primary outcome will be body fat mass (kg), which will be assessed using dual-energy x-ray absorptiometry (DXA) (performed only at visits 2 and 4). Secondary outcomes include body mass index, body weight, waist-to-hip ratio, body fat percentage (%) measured using DXA, lean body mass (kg) measured using DXA (assessed only at visits 2 and 4), lipids (total cholesterol, triglyceride, high-density lipoprotein cholesterol, and calculated low-density lipoprotein cholesterol), free fatty acid, high sensitivity C-reactive protein, adiponectin, and leptin. Conclusions: This protocol will be implemented after approval of Institutional Review Board of Pusan National University Korean Medicine Hospital (approval number: PNUKHIRB-2022-08-002) and registration with the Korean National Clinical Research Information Service (CRIS) (CRIS-KCT0008060). The results of this trial will provide potential of L. salicaria as a new anti-obesity functional food with fat-reducing effects and low toxicity.

• Journal of Preventive Medicine and Public Health
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• v.38 no.3
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• pp.330-336
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• 2005

Objectives : The aim of this study was to investigate the effects of bisphenol A (BPA), an estrogen-like environmental endocrine disrupter, on the placental function and reproduction in rats. The mRNA levels of the placental prolactin-growth hormone(PRL-GH) gene family, placental trophoblast cell frequency and reproductive data were analyzed. Methods : The pregnancies of F344 Fisher rats ($160g{\pm}20g$) were detected by the presence of the copulatory plug or sperm in the vaginal smear, which marked Day 0 of pregnancy. Pregnant rats were divided into three groups. The control group was intraperitoneally injected with a sesame oil vehicle. The two remaining groups were injected with 50 or 500 mg/kg B.W/day of BPA, resuspended in sesame oil, on either days 7 to 11 or 16 to 20 of pregnancy, with the rats sacrificed on either day 11 or 20, respectively. The mRNA levels of PRL-GH and Pit-1a and b isotype genes were analyzed by Northern blot hybridization and reverse transcription-polymerase chain reaction. The hormone concentrations were analyzed by radioimmunoassay, and the frequency of the placental trophoblast cells observed by a histochemical study. Reproductive data, such as the placental weight and litter size, were surveyed on day 20. The fetal weight was surveyed for 4 weeks after birth. A statistical analysis was carried out using the SAS program (version 8.1). Results : The mRNA levels of the PRL-GH gene family, such as placental lactogen I, Iv and II, prolactin like protein A, C and Cv, and decidual prolactin-related protein were significantly reduced due to BPA exposure. The mRNA levels of the Pit-1a and b isotype genes, which induce the expression of the PRL-GH gene family in the rat placenta, were also reduced due to BPA exposure. The PL-Iv and PL-II concentrations were reduced in the BPA exposed group. During the middle to last stage of pregnancy (Days 11-20), a high dose of BPA exposure reduced the frequency of spongiotrophoblast cells, which are responsible for the secretion of the PRL-GH hormones. Reproductive data, such as the placental and fetal weights and the litter size, were reduced, but that of the pregnancy period was extended in the BPA exposed compared to the control group. Conclusions : BPA disrupts the placental functions in rats, which leads to reproductive disorders.

• The korean journal of orthodontics
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• v.31 no.3 s.86
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• pp.357-367
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• 2001

The purpose of this study was to investigate the alveolar bone turnover in diabetic rat, and to compare the alveolar bone turnover during tooth movement in diabetes with that in normal control Eighty Male Sprague-Dawley strain rats(8th week) were divided into normal control(N), normal-tooth movement (N-tm), diabetes(D), and diabetes-tooth movement(D-tm) groups. Eighteen days before the start of the experiment, diabetes was induced with a single injection of streptozotocin 50 mg/kg of body weight in citrate buffer as vehicle via the tail vein. Maxillary first molars of rats were moved mesially by 40 grams of the closed coil spring. Experimental animals were sacrificed after 1d, 3d, 7d, and 14d experimental period, and the alveolar bone around the maxillary first molars were assayed biochemically for acid phsophatase(ACP) and tartrate-resistant acid phosphatase (TRAP) as bone resorption markers, and alkaline phosphatase(ALP) and osteocalcin(OC) as bone formation markers. TRAP and OC concentration in serum and alveolar bone of D group were lower than those in N group, and especially OC concentration decreased mote following diabetes prolonged, which showed the decreased skeletal and alveolar bone resorption and formation potential in diabetic rats. In N-tm group compared with N group, alveolar bone ACP and TRAP concentrations were highest at 1d and 3d(p<0.01), decreased after then, and showed lowest at 14d, and alveolar bone OC concentration was higher at 3d, 7d, and 14d(p<0.001) and showed a tendency of peak level at 7d. which showed the peak of concentration of bone resorption markets at 1d-3d and those of bone formation markers at 7d. In D-tm group compared with N group, alveolar bone ACP and TRAP concentrations were higher at 3d, 7d and 14d(p<0.001), and tended to reach peak value at 7d and persisted through 14d, and alveolar bone ALP and OC concentration increased but not different from that of N group. The amount of tooth movement in D group were greater than that of N group at all experimental period. Those results were suggested that during diabetes, the alveolar and skeletal bone undergo low bone turnover and the mote amount of tooth movement, hut because the peak time of alveolar bone resorption activity was delayed and sustained in longer period of tooth movement and alveolar bone formation activity is lower than that of normal tooth movement, the periodontal space is supposed to be larger doting tooth movement.

• Korean Journal of Poultry Science
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• v.44 no.1
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• pp.1-9
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• 2017

The objective of the present study was to determine the expression of genes associated with lipopolysaccharide (LPS)-induced stressor in two breeds of chickens: the Korean native chicken (KNC) and the White Leghorn chicken (WLH). Forty chickens per breed, aged 40 weeks, were randomly allotted to the control (CON, administered the saline vehicle) and LPS-injected stress groups. Samples were collected at 0 and 48 h post-LPS injection, and total RNA was extracted from the chicken livers for RNA microarray and quantitative real-time polymerase chain reaction (qRT-PCR) analyses. In response to LPS, 1,044 and 1,193 genes were upregulated, and 1,000 and 1,072 genes were downregulated in the KNC and WLH, respectively, using a ${\geq}2$-fold cutoff change. A functional network analysis revealed that stress-related genes were downregulated in both KNC and WLH after LPS infection. The results obtained from the qRT-PCR analysis of mRNA expression of heat shock 90 (HSP90), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), activating transcription factor 4 (ATF4), sterol regulatory element-binding protein 1 (SREBP1), and X-box binding protein 1 (XBP1) were confirmed by the results of the microarray analysis. There was a significant difference in the expression of stress-associated genes between the control and LPS-injected KNC and WLH groups. The qRT-PCR analysis revealed that the stress-related $HSP90{\alpha}$ and HMGCR genes were downregulated in both LPS-injected KNC and WLH groups. However, the HSP70 and $HSP90{\beta}$ genes were upregulated only in the LPS-injected KNC group. The results suggest that the mRNA expression of stress-related genes is differentially affected by LPS stimulation, and some of the responses varied with the chicken breed. A better understanding of the LPS-induced infective stressors in chicken using the qRT-PCR and RNA microarray analyses may contribute to improving animal welfare and husbandry practices.