• Title/Summary/Keyword: vascular Compliance

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Design of Filter to remove motion artifacts of PPG signal using Amplitude Modulation of Optical Power and Independent Components Analysis (광전력 진폭변조와 ICA를 이용한 PPG 신호의 동잡음 제거 필터 설계)

  • Lee, Ju-Won;Lee, Byoung-Ro
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.3
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    • pp.691-697
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    • 2013
  • Recently, u-healthcare device is developed and commercialized for healthcare management and emergency medical. The kinds of the measurable biomedical signals on the device are electrocardiogram, skin temperature, pulse oxygen, heart rate, respiration, etc. Specially, the photoplethysmograph(PPG) signal of these signals is the important signal in measuring oxygen, heart rate and peripheral vascular compliance. The accuracy of PPG signal reduce from influence of the motion artifacts that generated from the movements of user or patient. Therefore, this study suggests a new method to remove the motion artifact that is using optical power modulation and ICA(Independent Component Analysis). For analyzing the proposed method, we used variety of noises made by artificially. In the results of experiments, the proposed method showed good performances than an adaptive filter.

TA Study on Maximum Oxygen Uptake according to Body Measurement and Vascular Compliance (신체계측치 및 혈관탄성도에 따른 최대산소섭취량에 관한 연구)

  • Nam, Young-Kyu;Kim, Keon-Yeop;Lee, Moo-Sik;Na, Baeg-Ju;Jang, Min-Young
    • Proceedings of the KAIS Fall Conference
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    • 2009.05a
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    • pp.236-239
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    • 2009
  • 본 연구는 40~50대 중년 남녀를 대상으로 신체계측을 통해 얻어진 신체계측치 및 혈관탄성도와 최대산소섭취량의 관련성을 규명하기 위하여 일개 군 보건소 운동처방실을 방문한 남자 43명, 여자 53명을 대상으로 신체계측치 및 혈관탄성도, 최대산소섭취량 등을 측정하였다.결과를 보면 1.남자의 신체계측치와 혈관탄성도의 상관관계에서는 비만도가, 여자에서는 허리-엉덩이비율이 유의한 상관관계를 보였다. 2.남자의 신체계측치와 최대산소섭취량의 상관관계에서는 비만도, 체질량지수, 허리-엉덩이비율, 체지방율이 유의한 상관관계를 보였으며, 여자에서는 허리-엉덩이 비율, 체지방율이 유의한 상관관계를 보였다. 3.남자의 혈관탄성도 및 심혈관계지표와 최대산소섭취량의 상관관계에서는 최대심박수가 유의한 상관관계를 보였고, 여자에서는 혈관탄성도, 최대심박수가 유의한 상관관계를 보였다. 최대 산소섭취량을 종속변수로 한 다중회귀분석에서는 남녀 모두 체지방율, 혈관탄성도, 최대심박수가 유의한 변수로 나타났다. 즉 체지방율이 낮을수록, 혈관탄성도가 높을수록, 최대심박수가 높을수록 최대 산소섭취량이 높았다. 따라서 40~50대 중년의 최대산소섭취량에 영향을 주는 요인에는 신체계측에 의한 비만관련지수, 혈관탄성도, 심혈관계지표 등 여러 요인들이 복합적으로 관련되는 것으로 판단되어진다.

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Mathematical Modeling and Simulation on the Control of Heart rate by Baroreceptor Control System in the Cardiovascular System (심혈관 시스템의 압수용체에 의한 심박동 제어의 수학적 모델링 및 시뮬레이션)

  • Choi, B.C.;Lee, S.J.;Eom, S.H.;Nam, G.K.;Lee, Y.W.;Jun, K.R.
    • Proceedings of the KOSOMBE Conference
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    • v.1996 no.11
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    • pp.80-85
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    • 1996
  • The various function of the cardiovascular system(CVS) and the dynamic characteristics on each part of human body can be acquired in the electric analog circuit model. According to the performed outcome by other researchers, viscos resistance, flow inertia, and vascular compliance in the CVS are analogous to resister, inductor, and capacitor in electric circuit, so the CVS models were represented by the electric circuit models. these approaches were to propose the suitable models interest part of body and to simulate the various characteristics on the CVS. In this paper, the electric circuit model considering the characteristics of morphologic structure is represented, the parameter values of model is sotted up, and the dynamic characteristics of the the CVS is simulated using VisSim, one of the simulation tools. The observed simulation results are similar to the cardiovascular functions of nomal adults who have no heart failure. Besides, the simulation is operated to observe the pathophysiological abnomal symptoms(for example, bleeding within a certain period). The controller by baroreceptor, which is one of controllers to control the CVS, is appended in the model. and the dynamic response characteristics and the procedure to return normal state is observed in simulation when the bleeding last within a certain period.

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A Study on the Changes of Blood Pressure Measurement Factors Before and After Heart Treatment (심장 치료 전후의 혈압 측정 인자의 변화에 관한 연구)

  • Choi, Wonsuk
    • Journal of the Institute of Convergence Signal Processing
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    • v.22 no.2
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    • pp.51-56
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    • 2021
  • The brachial systolic blood pressure and pulse pressure are the predictors of cardiovascular disease in individuals over 50 years of age. As the stiffness increases, the reflex amplitude and pressure in the late systole increase, resulting in an increase in left ventricular load and myocardial oxygen demand. Therefore, it is necessary to study how stiffness affects blood pressure. In this study, the blood pressure pulse waves were measured before and after taking the drug, and the blood pressure pulse wave was measured before and after myocardial heart transplantation in patients with heart failure. The correlation between R, L, and C components of the Windkessel model was estimated by increasing blood pressure. As a result of modeling the parameters of the Windkessel model using the curve fitting method, the increase in blood pressure and decrease in systolic rise time were due to the increase in the L component in the RLC Windkessel model. Among the various mechanical characteristics of blood vessels, the most important parameter affecting high BP waveform is the inertance.

Effect of Recovery of Pulmonary Function in Hypothermic Lung Preservation (肺의 低溫保存法이 肺機能 回復에 미치는 영향)

  • Lee, Man Bok;Kim, U Jong;Gang, Chang Hui;Lee, Gil No
    • Journal of Chest Surgery
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    • v.30 no.3
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    • pp.253-253
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    • 1997
  • Hypothermia during lung preservation decreases metabolic processes. After the rabbit lung was flushed with modified Euro-Collins solution, heart-lung block was harvested and the left lung was assessed after ligation of the right pulmonary artery and right main-stem bronchus. Heart-lung block was immersed in the same solution for 6 hours. The modified Euro-Collins solution and storage temperature of group 1(10 cases) was 4t, roup 2(10 cases) was l0℃. On completion of the storage period, the left lung was ventilated and reperfused with blood u:high used a cross-circulating paracorporeal rabbit as a "biologic deoxygenator" for 60 minutes. Pulmonary artery pressure, airway pressure, difference in oxygen tension between mow and outflow perfusate and degree of pulmonary edema were assessed at 10-minute intervals while the left lung was ventilated at 0.8 of the inspired oxygen fraction. The mean pulmonary venous oxygen tensions at 10 and 60 minutes after reperfusion were 209.52±42.46 and 103.48± 15.96 mmHg in group I versus 247.78±36.19 and 147.91 ± 11.07 mmHg in group II(p=0.049, (0.0001). The mean alveolar-arterial oxygen differences at 20 and 60 minutes after reperfusion were 357. 95± 12.84 and 437.31 14.26 mmHg in group I versus 310.88±3).47 and )90.93± 15.86 mmHg in group II (p=0.0092, (0.0001). The mean pulmonary arterial pressures at 10 and 60 minutes after reperfusion were 40.56± 18.66 and 87. 2± 17.22 mmHg in group I versus 31.22±6.84 and 65.78± 11.02 mmHg in group rl (p : 0.048, 0.0062). The mean pulmonary vascular resistances at 10 and 60 minutes after reperfusion were 2.69±0.85 and 4.36±0.86 mmHg/ml/min in group I versus 1.99±0.39 and 3.29±0.55 mmHg/ml/min in group II(p : 0.0323, 0.0062). There were no difference between groups in peak airway pressure, lung compliance and degree of pulmonary edema. In conclusion that preservation of lung at l0℃ was superior to preservation at 4℃.

TREATMENT OF OPENBITE WITH MYOFUNCTIONAL THERAPY IN MOYAMOYA DISEASE PATIENT (근기능요법을 통한 모야모야병 환자의 개방 교합 치료)

  • Lee, Chang Keun;Lee, Dae Woo;Kim, Jae Gon;Yang, Yeon Mi
    • The Journal of Korea Assosiation for Disability and Oral Health
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    • v.13 no.1
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    • pp.19-22
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    • 2017
  • Moyamoya disease is characterized by progressive bilateral narrowing of the internal carotid arteries(ICA) and their main branches, and formation of a fine vascular network (moyamoya vessels) at the base of brain. Mild intellectual or motor impairment, or both can be seen in moyamoya disease patient. Patients having intellectual disability usually have malocclusions associated with oral habits such as tongue thrusting, bruxism, or clenching. A patient with moyamoya disease and cerebral palsy visited Chonbuk National University hospital for dental examination. She showed mild openbite on anterior teeth, and had oral habits such as mouth breathing, tongue thrusting, and drooling. She was treated with myofunctional therapy(MFT) whose purpose was to strengthen orofacial muscles. Lip closing force and bite force were recorded to evaluate the muscle tone. Tongue crib was delivered to restrict tongue thrusting habit, since her compliance to the MFT was decreased after 6 months of treatment. With the MFT and tongue crib, the openbite was fairly improved. When myofunctional therapy has difficulty in obtaining good compliances, the treatment should not be effective enough. Although intellectually disabled patients are not compliant enough, thus a habit breaking device should be needed to treat the openbite caused by oral habits, dentist should make an effort to do MFT, since it could reduce a treatment period, and enhance the stability.

Diverse Mechanisms of Relaxin's Action in the Regulation of Smooth Muscles and Extracellular Matrix of Vasculature and Fibrosis (혈관과 섬유증의 평활근 및 세포외기질 조절에 대한 릴랙신의 다양한 작용기전)

  • Min, Gyesik
    • Journal of Life Science
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    • v.32 no.2
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    • pp.175-188
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    • 2022
  • Relaxin has been demonstrated to have regulatory functions on both the smooth muscle and extracellular matrix (ECM) of blood vessels and fibrotic organs. The diverse mechanisms by which relaxin acts on small resistance arteries and fibrotic organs, including the bladder, are reviewed here. Relaxin induces vasodilation by inhibiting the contractility of vascular smooth muscles and by increasing the passive compliance of vessel walls through the reduction of ECM components, such as collagen. The primary cellular mechanism whereby relaxin induces arterial vasodilation is mediated by the endothelium-dependent production of nitric oxide (NO) through the activation of RXFP1/PI3K, Akt phosphorylation, and eNOS. In addition, relaxin triggers different alternative pathways to enhance the vasodilation of renal and mesenteric arteries. In small renal arteries, relaxin stimulates the activation of the endothelial MMPs and EtB receptors and the production of VEGF and PlGF to inhibit myogenic contractility and collagen deposition, thereby bringing about vasodilation. Conversely, in small mesenteric arteries, relaxin augments bradykinin (BK)-evoked relaxation in a time-dependent manner. Whereas the rapid enhancement of the BK-mediated relaxation is dependent on IKCa channels and subsequent EDH induction, the sustained relaxation due to BK depends on COX activation and PGI2. The anti-fibrotic effects of relaxin are mediated by inhibiting the invasion of inflammatory immune cells, the endothelial-to-mesenchymal transition (EndMT), and the differentiation and activation of myofibroblasts. Relaxin also activates the NOS/NO/cGMP/PKG-1 pathways in myofibroblasts to suppress the TGF-β1-induced activation of ERK1/2 and Smad2/3 signaling and deposition of ECM collagen.

Can Peritoneal Dialysis Remove Endothelin-1 after Cardiopulmonary Bypass for Repair of Congenital Heart Disease? (체외순환을 이용한 선천성 심장수술 후에 시행한 복막투석이 내피의존성 혈관 활성 물질인 Endothelin-1을 제거할 수 있는가?)

  • Chang, Yun-Hee;Ban, Ji-Eun;Lee, Hyoung-Doo;Lee, Sun-Hee;Rhym, Byuong-Yong;Sung, Si-Chan
    • Journal of Chest Surgery
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    • v.40 no.4 s.273
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    • pp.247-255
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    • 2007
  • Background: Lung injury that follows bypass has been well described. It is manifested as reduced oxygenation and lung compliance and, most importantly, increased pulmonary vascular resistance reactivity; this is a known cause of morbidity and mortality after repair of congenital heart disease. Injury to the pulmonary vascular endothelium, and its associated alterations of endothelin-1, is considered to be a major factor of bypass-induced lung injury. Removing endothelin-1 after bypass may attenuate this response. This study measured the concentration of serum and peritoneal effluent endothelin-1 after performing bypass to determine if endothelin-1 can be removed via peritoneal dialysis. Material and Method: From March 2005 to March 2006, 18 patients were enrolled in this study Peritoneal catheters were placed at the end of surgery. Serum samples were obtained before and after bypass, and peritoneal effluents were obtained after bypass. Endothelin-1 was measured by enzyme linked immunosorbent assay (ELISA). Result: In the patients with a severe increase of the pulmonary artery pressure or flow, the mean preoperative plasma endothelin-1 concentration was significantly higher than that in the patients who were without an increase of their pulmonary artery pressure or flow (4.2 vs 1.8 pg/mL, respectively, p<0.001). The mean concentration of plasma endothelin-1 increased from a preoperative value of $3.61{\pm}2.17\;to\;5.33{\pm}3.72 pg/ml$ immediately after bypass. After peritoneal dialysis, the mean plasma endothelin-1 concentration started to decrease. Its concentration at 18 hours after bypass was significantly lower than the value obtained immediately after bypass (p=0.036). Conclusion: Our data showed that the plasma endothelin-1 concentration became persistently decreased after starting peritoneal dialysis, and this suggests that peritoneal dialysis can remove the circulating plasma endothelin-1.

Effect of Recovery of Pulmonarv Function in Hypothermic Lung Preservation (폐의 저량보존법이 폐기능 회복에 미치는 영향)

  • Lee, Man-Bok;Kim, U-Jong;Gang, Chang-Hui;Lee, Gil-No
    • Journal of Chest Surgery
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    • v.30 no.3
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    • pp.253.1-262
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    • 1997
  • Hypothermia during lung preservation decreases metabolic processes. After the rabbit lung was flushed with modified Euro-Collins solution, heart-lung block was harvested and the left lung was assessed after ligation of the right pulmonary artery and right main-stem bronchus. Heart-lung block was immersed in the same solution for 6 hours. The modified Euro-Collins solution and storage temperature of group 1(10 cases) was 4t, roup 2(10 cases) was l$0^{\circ}C$. On completion of the storage period, the left lung was ventilated and reperfused with blood u:high used a cross-circulating paracorporeal rabbit as a "biologic deoxygenator" for 60 minutes. Pulmonary artery pressure, airway pressure, difference in oxygen tension between mow and outflow perfusate and degree of pulmonary edema were assessed at 10-minute intervals while the left lung was ventilated at 0.8 of the inspired oxygen fraction. The mean pulmonary venous oxygen tensions at 10 and 60 minutes after reperfusion were 209.52$\pm$42.46 and 103.48$\pm$ 15.96 mmHg in group I versus 247.78$\pm$36.19 and 147.91 $\pm$ 11.07 mmHg in group II(p=0.049, (0.0001). The mean alveolar-arterial oxygen differences at 20 and 60 minutes after reperfusion were 357. 95$\pm$ 12.84 and 437.31 14.26 mmHg in group I versus 310.88$\pm$3).47 and )90.93$\pm$ 15.86 mmHg in group II (p=0.0092, (0.0001). The mean pulmonary arterial pressures at 10 and 60 minutes after reperfusion were 40.56$\pm$ 18.66 and 87. 2$\pm$ 17.22 mmHg in group I versus 31.22$\pm$6.84 and 65.78$\pm$ 11.02 mmHg in group rl (p : 0.048, 0.0062). The mean pulmonary vascular resistances at 10 and 60 minutes after reperfusion were 2.69$\pm$0.85 and 4.36$\pm$0.86 mmHg/ml/min in group I versus 1.99$\pm$0.39 and 3.29$\pm$0.55 mmHg/ml/min in group II(p : 0.0323, 0.0062). There were no difference between groups in peak airway pressure, lung compliance and degree of pulmonary edema. In conclusion that preservation of lung at l$0^{\circ}C$ was superior to preservation at 4$^{\circ}C$.}C$.

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