• BMB Reports
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• v.54 no.9
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• pp.451-457
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• 2021

Over the last decades, research has focused on the role of pleckstrin homology (PH) domain leucine-rich repeat protein phosphatases (PHLPPs) in regulating cellular signaling via PI3K/Akt inhibition. The PKB/Akt signaling imbalances are associated with a variety of illnesses, including various types of cancer, inflammatory response, insulin resistance, and diabetes, demonstrating the relevance of PHLPPs in the prevention of diseases. Furthermore, identification of novel substrates of PHLPPs unveils their role as a critical mediator in various cellular processes. Recently, researchers have explored the increasing complexity of signaling networks involving PHLPPs whereby relevant information of PHLPPs in metabolic diseases was obtained. In this review, we discuss the current knowledge of PHLPPs on the well-known substrates and metabolic regulation, especially in liver, pancreatic beta cell, adipose tissue, and skeletal muscle in relation with the stated diseases. Understanding the context-dependent functions of PHLPPs can lead to a promising treatment strategy for several kinds of metabolic diseases.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.9
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• pp.4408-4428
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• 2019

Due to the rapid advancement in smart phones, numerous new specifications are developed for variety of applications ranging from health monitoring to navigations and tracking. The word indoor navigation means location identification, however, where GPS signals are not available, accurate indoor localization is a challenging task due to variation in the received signals which directly affect distance estimation process. This paper proposes a hybrid approach which integrates fingerprinting based K-Nearest Neighbors (K-NN) and lateration based MinMax position estimation technique. The novel idea behind this hybrid approach is to use Euclidian distance formulation for distance estimates instead of indoor radio channel modeling which is used to convert the received signal to distance estimates. Due to unpredictable behavior of the received signal, modeling indoor environment for distance estimates is a challenging task which ultimately results in distance estimation error and hence affects position estimation process. Our proposed idea is indoor position estimation technique using Bluetooth enabled smart phones which is independent of the radio channels. Experimental results conclude that, our proposed hybrid approach performs better in terms of mean error compared to Trilateration, MinMax, K-NN, and existing Hybrid approach.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.1
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• pp.20-34
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• 2021

Today, IoT devices are flooding, and traffic is increasing rapidly. The Internet of Things creates a variety of added value through connections between devices, while many devices are easily targeted by attackers due to security vulnerabilities. In the IoT environment, security diagnosis has problems such as having to provide different solutions for different types of devices in network situations where various types of devices are interlocked, personal leakage of security solutions themselves, and high cost, etc. To avoid such problems, a TCP-based active scan was presented. However, the TCP-based active scan has limitations that it is difficult to be applied to real-time systems due to long detection times. To complement this, this study uses UDP-based approaches. Specifically, a lightweight active scan algorithm that effectively identifies devices using UPnP protocols (SSDP, MDNS, and MBNS) that are most commonly used by manufacturers is proposed. The experimental results of this study have shown that devices can be distinguished by more than twice the true positive and recall at an average time of 1524 times faster than Nmap, which has a firm position in the field.

• BMB Reports
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• v.55 no.3
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• pp.113-124
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• 2022

Single-cell RNA sequencing (scRNA-seq) has greatly advanced our understanding of cellular heterogeneity by profiling individual cell transcriptomes. However, cell dissociation from the tissue structure causes a loss of spatial information, which hinders the identification of intercellular communication networks and global transcriptional patterns present in the tissue architecture. To overcome this limitation, novel transcriptomic platforms that preserve spatial information have been actively developed. Significant achievements in imaging technologies have enabled in situ targeted transcriptomic profiling in single cells at single-molecule resolution. In addition, technologies based on mRNA capture followed by sequencing have made possible profiling of the genome-wide transcriptome at the 55-100 ㎛ resolution. Unfortunately, neither imaging-based technology nor capture-based method elucidates a complete picture of the spatial transcriptome in a tissue. Therefore, addressing specific biological questions requires balancing experimental throughput and spatial resolution, mandating the efforts to develop computational algorithms that are pivotal to circumvent technology-specific limitations. In this review, we focus on the current state-of-the-art spatially resolved transcriptomic technologies, describe their applications in a variety of biological domains, and explore recent discoveries demonstrating their enormous potential in biomedical research. We further highlight novel integrative computational methodologies with other data modalities that provide a framework to derive biological insight into heterogeneous and complex tissue organization.

• Acta Via Serica
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• v.7 no.2
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• pp.39-64
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• 2022

Ancient Iranians highly esteemed the horse and horse tacks, one of which is the jul (saddlecloth). It is a felt, sheepskin, or woven pad placed between the horse's back and saddle. The aim of this paper is to identify and categorize jul designs in the Sāsānian period. The research questions are about the variety of jul designs and how to categorize them. This is fundamental research and the method is descriptive and analytical. Neither a jul nor a saddle-cover remains from the Sāsānian period, therefore the statistical population includes all available items, such as metal and stone items and parget and plasterworks, in which juls are recognizable. Due to the scarcity of such items, all the available samples were studied; so the sampling method is a total enumeration. This is documentary research by means of note-taking and using reliable websites; the data has been analyzed qualitatively. The results show that jul designs were not diverse in the Sāsānian period. All-over designs were dominant. In terms of pattern types, these designs are classified into five groups, each of which has its own formal and aesthetic characteristics: all-over design with a four-petal flower pattern, allover design with a checkered pattern, all-over design with a spotted pattern, allover design with a tiger stripe pattern, and all-over design with a zigzag pattern.

• Archives of Craniofacial Surgery
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• v.24 no.4
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• pp.145-158
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• 2023

Vascular anomalies encompass a variety of malformations and tumors that can result in severe morbidity and mortality in both adults and children. Advances have been made in the classification and diagnosis of these anomalies, with the International Society for the Study of Vascular Anomalies establishing a widely recognized classification system. In recent years, notable progress has been made in genetic testing and imaging techniques, enhancing our ability to diagnose these conditions. The increasing sophistication of genetic testing has facilitated the identification of specific genetic mutations that help treatment decisions. Furthermore, imaging techniques such as magnetic resonance imaging and computed tomography have greatly improved our capacity to visualize and detect vascular abnormalities, enabling more accurate diagnoses. When considering reconstructive surgery for facial vascular anomalies, it is important to consider both functional and cosmetic results of the procedure. Therefore, a comprehensive multidisciplinary approach involving specialists from dermatology, radiology, and genetics is often required to ensure effective management of these conditions. Overall, the treatment approach for facial vascular anomalies depends on the type, size, location, and severity of the anomaly. A thorough evaluation by a team of specialists can determine the most appropriate and effective treatment plan.

• Journal of Animal Science and Technology
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• v.65 no.2
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• pp.293-310
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• 2023

Protein-translated mRNA analysis has been extensively used to determine the function of various traits in animals. The non-coding RNA (ncRNA), which was known to be non-functional because it was not encoded as a protein, was re-examined as it was studied to actually function. One of the ncRNAs, long non-coding RNA (lncRNA), is known to have a function of regulating mRNA expression, and its importance is emerging. Therefore, lncRNAs are currently being used to understand the traits of various animals as well as human diseases. However, studies on lncRNA annotation and its functions are still lacking in most animals except humans and mice. lncRNAs have unique characteristics of lncRNAs and interact with mRNA through various mechanisms. In order to make lncRNA annotations in animals in the future, it is essential to understand the characteristics of lncRNAs and the mechanisms by which lncRNAs function. In addition, this will allow lncRNAs to be used for a wider variety of traits in a wider range of animals, and it is expected that integrated analysis using other biological information will be possible.

• Journal of Microbiology and Biotechnology
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• v.33 no.2
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• pp.242-250
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• 2023

Comparative gene identification-58 (CGI-58) is an activating protein of triacylglycerol (TAG) lipase. It has a variety of catalytic activities whereby it may play different roles in diverse organisms. In this study, a homolog of CGI-58 in Phaeodactylum tricornutum (PtCGI-58) was identified. PtCGI-58 was localized in mitochondria by GFP fusion protein analysis, which is different from the reported subcellular localization of CGI-58 in animals and plants. Respectively, PtCGI-58 overexpression resulted in increased neutral lipid content and TAG accumulation by 42-46% and 21-32%. Likewise, it also increased the relative content of eicosapentaenoic acid (EPA), and in particular, the EPA content in TAGs almost doubled. Transcript levels of genes involved in de novo fatty acid synthesis and mitochondrial β-oxidation were significantly upregulated in PtCGI-58 overexpression strains compared with wild-type cells. Our findings suggest that PtCGI-58 may mediate the breakdown of lipids in mitochondria and the recycling of acyl chains derived from mitochondrial β-oxidation into TAG biosynthesis. Moreover, this study potentially illuminates new functions for CGI-58 in lipid homeostasis and provides a strategy to enrich EPA in algal TAGs.

• The Korean Journal of Mycology
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• v.50 no.4
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• pp.255-262
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• 2022

In this study, the fungal strain KNUF-21-F39 was isolated from a declined apple tree (Malus domestica) in the Chungcheongbuk province in Korea. The strain KNUF-21-F39 presented a slow growth rate and a variety of macroconidia shapes and sizes ranging from ovoid to fusoid and 1- to 5-septate, primarily showing 3- and 4-septate, with "S" -shaped macroconidia rarely observed. The strain was identified based on morphological characteristics along with phylogenetic analysis performed using the internal transcribed spacer region (ITS) and partial sequences of translation elongation factor 1-α (tef1), RNA polymerase largest subunit (rpb1), and calmodulin (cal) genes. The fungal strain KNUF-21-F39 was identified as Fusarium diversisporum, which has not been previously reported in Korea. The ice nucleation activity (INA) of the strain was also evaluated, identifying the strain as positive for INA. This is the first report characterizing F. diversisporum as an IN-active fungal species.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.558-565
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• 2013

The process and efficiency of monitoring building and construction violations is a concern of the construction industry. The detection of violations requires appropriate and sufficiently accurate spatial information to manage and support a comprehensive inspection process and monitor compliance. A building inspection workflow must extract appropriate spatial and measurement in-formation from a variety of sources, identify potential violations across a range of compliance criteria and determine the quality of resulting inspection reports. This paper presents a framework for supporting building inspections using spatial information and methods to detect construction violations and compliance. Current inspection processes involve issues around the identification of building violations, access to building regulations and existing spatial information, integration of a range of spatial and non-spatial information, and the quality of decisions within the inspection workflows. A survey of building inspectors was conducted and used together with the issues identified to establish the requirements for a spatial inspection framework. The results demonstrate how such a framework can support improved decision-making and reduced fieldwork effort in detecting and measuring the accuracy of building violations involving building placements, street offsets and footprint areas.