• Health Policy and Management
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• v.17 no.1
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• pp.94-124
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• 2007

This paper critically reviews three decades of research on geographic variations. in health services utilization in the United States, thereby drawing policy and research implications for Korea. The recent renewed interest in variations research in the United States, precipitated by studies on regional variations in Medicare expenditures, stems mainly from the policy implication that a substantial amount of Medicare expenditures could be saved without compromising quality and access. From the research perspective, this policy implication was made tenable by integrating micro- and macro-level analysis of variations in health services utilization. Still, theoretical limitations inherent in the research pose great challenges to developing effective strategies at the health system level. Variations research in the United States can serve as a case study as to how health services research has responded to efficiency and quality issues in an ever expanding health system Considering the current health policy and research environment in Korea, the following implications can be drawn. Variations research will help formulate a national policy agenda for health care quality and also advance the framework of approaches to health policy issues. For such purposes, both relevant descriptive and hypothesis-testing studies are needed. Further advancement in variations research will require interdisciplinary explorations and methodological sophistication. To the extent that Korean health policies will strive to achieve complex goals, variations research will increasingly prove to be useful.

• Ocean Systems Engineering
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• v.7 no.3
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• pp.225-246
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• 2017

Excessive dynamic-tension variations on the top-tensioned risers (TTRs) deteriorate the structural integrity and cause potential safety hazards. This phenomenon has become more remarkable in the development of deep-water fields with harsher environmental loads. The conventional prediction method of tension variations in hydro-pneumatic tensioner (HPT) has the disadvantage to underestimate the magnitude of cyclic loads. The actual excessive dynamic tension variations are larger when considering the viscous frictional fluid effects. In this paper, a suppression method of tension variations in HPT is modeled by incorporating the magneto-rheological (MR) damper and linear-force actuator. The mathematical models of the combined HPT and MR damper are developed and a force-control scheme is introduced to compensate the excessive tension variations on the riser tensioner ring. Numerical simulations and analyses are conducted to evaluate the suppression of tension variations in HPT under both regular- and irregular-wave conditions for a drilling riser of a tensioned-leg platform (TLP). The results show that significant reduction of tension variations can be achieved by introducing the proposed system. This research has provided a theoretical foundation for the HPT tension control and related structural protection.

• Korean Journal of Veterinary Research
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• v.8 no.2
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• pp.59-64
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• 1968

The serum and erythrocyte cholinesterase activity and their seasonal variations were determined with 8 males of healthy Korean cattles during one year period from September, 1966 to august, 1977. The results obtained were as follows : 1. The serum cholinestrase activity showed a range of 0.64mg/hr/ml to 8.26mg/hr/ml with a mean value of $3.69{\pm}0.25mg/hr/ml$. There was highly significant differences in the seasonal variations. 2. The erythrocyte cholinesterase activity ranged from 29.78mg/hr/ml to 48.88mg/hr/ml with a mean value of $38.37{\pm}1.11mg/hr/ml$. Seasonal variations was not found to be significant. 3. The results showed that the serum cholinesterase activity of Korean cattle had great variations among individual values and significant seasonal variations. On the other hand, cholinesterase activity of erythrocyte showed a little variations among individual values and no significant seasonal variations.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.101-108
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• 2018

G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2001.10a
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• pp.290-294
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• 2001

Satellite data, with Sea Surface Temperature(SST) by NOAA and Sea Level(SL) by Topex/poseidon, are used to estimate characteristics on the variations and correlations of SST and SL in the East Asian Seas from January 1993 through May 1998. In the oceanic climate, the variations of SL shown the high values in the main current of Kuroshio and the variations of SST shown not the remarkable seasonal variations because of the continuos compensation of warm current by Kuroshio. In the continental climate, SL shown high variations in the estuaries(the Yellow River, the Yangtze River) with the mixing the fresh water in the mouth of estuaries of the saline water in the coasts of continent and SST shown highly the seasonal variations due to the climatic effect of continents. In the steric variations in summer, the eastern sea of Japan, the East China Sea and the western sea of Korea shown the increment of sea level with 10~20cm. But the Bohai bay in China shown relatively the high values of 20~30cm due to the continental climate. Generally the trends of SST and SL increased during all periods. That is say, the slopes of SST and SL presented 0.29$^{\circ}C$/year and 0.84cm/year, respectively. The annual and semi-annual amplitudes shown a remarkable variations in the western sea of Korea and the eastern sea of Japan.

• Fashion & Textile Research Journal
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• v.1 no.4
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• pp.393-396
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• 1999

The purpose of this study was to suggest the knowledge and scientific information of the damage and improvement according to hair coloring manipulation. The study investigated variations of mechanical, nourishment(amino acid cystine) shape of cuticle characteristics according to hair coloring during 40, 50 minute. The results were as follows; Tensile strength was decreased variations of 6.62%, 13.68%, extension rate was increased variations of 10.58%, 12.28%, thickness was increased variations of 9.15%, 15.64% in 40 min. and 50 min. hair coloring. Content of amino acid cystine was lowered variations of 23.00%, 30.49% according to time of manipulation. A shape of cuticles was disfigured and brocken by reason of hair coloring manipulation.

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.2
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• pp.403-420
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• 1997

In this paper, we examine the effect of production uncertainty to production control policies. First, we examine two famous production control policies, namely, MRP and JIT from the view point of shop floor control perspective, and analyze the differences between them due to demand fluctuations and activity time variations. Second, we conduct simulation studies on MRP and JIT to draw out the effects of demand fluctuations and activity time variations. Demand fluctuations are further classified into demand lumpiness and demand irregularity. And, activity time variations are further classified into stationary time variations and non-stationary time variations. Experimental results show that, in terms of demand fluctuations, MRP is affected by demand lumpiness, but JIT by demand irregularity. And we also see that both MRP and JIT are influenced by stationary time variation with respect to activity time variations.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1998.06a
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• pp.87-91
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• 1998

In this paper, We analyzed the current-voltage characteristics with n-type silicon substrates concentration and temperature variations (Room temperature, 50$^{\circ}C$, 75$^{\circ}C$) in platinum silicide and silicon junction. The electrical parameters of measurement are turn-on voltage, saturation current, ideality factor, barrier height, dynamic resistance in forward bias and reverse breakdown voltage according to variations of junction concentration of substrates and measurement temperature variations. As a result, the forward turn-on voltage, reverse breakdown voltage, barrier height and dynamic resistance were decreased but saturation currents and ideality factor were increased by substrates increased concentration variations in platinum silicide and n-silicon junction. In increased measurement temperature (RT, 50$^{\circ}C$, 75$^{\circ}C$), the extracted electrical parameter values of characteristics were rises by increased temperature variations according to the forward and reverse bias.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.55.1-55.1
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• 2019

Recently, temporal variations of the 3-micron emissions of methane and ethane have been detected in the auroral regions of Jupiter observed from Gemini North (Kim et al. 2019, in preparation). These temporal variations of 3-micron hydrocarbon emissions in the auroral regions can be caused by the following phenomena: temporal variations of temperatures, mixing ratios, auroral particle bombardments and Joule heatings, and the combinations of these. Although we are not able to quantitatively determine the cause of the temporal variations at this moment, we will present the following quantitative discussions: thermal influences on the 3-micron emissions, global mixing ratio distributions of the hydrocarbon molecules, and energy distributions of auroral particles penetrating the hydrocarbon layers. We will also present a possible correlation between the temporal variations of the 3-micron emissions and solar wind activities.

• Journal of Environmental Science International
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• v.10 no.6
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• pp.423-429
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• 2001

Satellite data, with sea surface temperature(557) by NOAA and sea level(SL) by Topex/poseidon, are used to estimate characteristics on the variations and correlations of 557 and SL in the East Asian Seas from January 1993 through May 1998. We found that there are two climatic characteristics in the East Asian seas the oceanic climate, the eastern sea of Japan, and the continental climate, the eastern sea of China, respectively. In the oceanic climate, the variations of SL have the high values in the main current of Kuroshio and the variations of 557 have not the remarkable seasonal variations because of the continuos compensation of warm current by Kuroshio. In the continental climate, SL has high variations in the estuaries(the Yellow River, the Yangtze River) with the mixing the fresh water and the saline water in the coasts of continent and 557 has highly the seasonal variations due to the climatic effect of continents. In the steric variations of summer, the eastern sea of Japan, the East China Sea and the western sod of Korea is increased the sea level about 10~20cm. But the Bohai bay in China have relatively the high values about 20~30cm due to the continental climate. generally the trends of SST and SL increased during all periods. That is say, the slopes of 557 and SL Is presented 0.29$^{\circ}C$/year and 0.84cm/year, respectively. The annual and semi-annual amplitudes have a remarkable variations in the western sea of Korea and the eastern sea of Japan. In the case of the annual peaks, there appeared mainly In the western sea of Korea and the eastern sea of .Japan because of the remarkable variations of SL associated with Kuroshio. But in the case of the semi-annual peaks, there appeared in the eastern sea of Japan by the influence of current, and in the western sea of Korea by the influence of seasonal temperature, respectively. From our results, it should be believed that 557 and SL gradually Increase in the East Asian seas concerning to the global warming. So that, it should be requested In the international co-operation against In the change of the abnormal climate.