• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4518-4526
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• 2023

NECP-SARAX is a neutronics analysis code system for advanced reactor developed by Nuclear Engineering Computational Physics Laboratory of Xi'an Jiaotong University. In past few years, improvements have been implemented in TULIP code which is the cross-section generation module of NECP-SARAX, including the treatment of resonance interface, considering the self-shielding effect in non-resonance energy range, hyperfine group method and nuclear library with thermal scattering law. Previous studies show that NECP-SARAX has high performance in both fast and thermal spectrum system analysis. The accuracy of TULIP code in fast and thermal spectrum system analysis is demonstrated preliminarily. However, a systematic verification and validation is still necessary. In order to validate the applicability of TULIP code for full energy range, 147 fast spectrum critical experiment benchmarks and 170 thermal spectrum critical experiment benchmarks were selected from ICSBEP and used for analysis. The keff bias between TULIP code and reference value is less than 300 pcm for all fast spectrum benchmarks. And that bias keeps within 200 pcm for thermal spectrum benchmarks with neutron-moderating materials such as polyethylene, beryllium oxide, etc. The numerical results indicate that TULIP code has good performance for the analysis of fast and thermal spectrum system.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2369-2374
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• 2016

Background: Differentiated thyroid cancer (DTC) is a cancer group that shares molecular and cellular origin but shows different clinical courses and prognoses. Several prognostic factors have been reported for predicting recurrence for individual patients. This literature review aimed to evaluate prognostic scores for predicting recurrence of DTC. Materials and Methods: A search of the MEDLINE database for articles published until December 2015 was carried out using the terms "thyroid neoplasms AND (recurrent OR persistent) AND (score OR model OR nomogram)". Studies were eligible for review if they indicated the development of prognostic scoring models, derived from a group of independent prognostic factors, in predicting disease recurrence in DTC patients. Results: Of the 308 articles obtained, five were eligible for evaluation. Two scoring models were developed for DTC including both papillary and follicular carcinoma, one for papillary carcinoma, and the other two for papillary microcarcinoma. The number of patients included in the score development cohort ranged from 59 to 1,669. The number of evaluated potential prognostic factors ranged from 4 to 25. Tumor-related factors were the most common factors included in the final scores, with cervical lymph node metastases being the most common. Only two studies showed internal validation of the derived score. Conclusions: There is a paucity of prognostic scores for predicting disease recurrence in patients with DTC, in particular for follicular thyroid carcinoma. Several limitations of the created scores were found. Performance of the scores has not been adequately studied. Comprehensive validation in multiple cohorts is recommended before widespread use.

• 한국생활과학회지
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• 제24권4호
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• pp.477-497
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• 2015

The purpose of this study was to examine the psychometric property of the Children's Behavior Questionnaire(CBQ), including reliability, content validity, construct validity, cross validity, and concurrent validity with EAS(Emotionality, Activity, Sociability) scale. The CBQ is a caregiver report measure designed to provide a detailed assessment of temperament in children 3 to 7 years of age. In this study, two groups of participants were included to check cross validity. The first group of participants were 108 preschoolers, 3 to 7 years of age attending kindergartens or child care centers, and their mothers. The second group of participants were 168 preschoolers and their mothers. The CBQ subscales demonstrate adequate internal consistencies. Also, exploratory and confirmatory factor analyses of the CBQ scale reliably recover a three-factor solution indicating three broad dimension of temperament: extraversion/surgency, negative affectivity, and effortful control. Evidence for concurrent validity derives from results of correlation analysis with EAS scale.

• 한국생활과학회지
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• 제23권6호
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• pp.1013-1033
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• 2014

This study attempted to develop a valid and reliable instrument capable of measuring Korea midlife family resilience (The Korea Midlife Family Resilience Scale: KMFRS). An exploratory, non-experimental, cross-sectional, and quantitative design was used to develop and validate the KMFRS. A tentative factor structure of family resilience and an item pool of the scale were constructed through a comprehensive literature review and personal interview. The pilot study was conducted with 424 middle aged adults(40~59) to select items for a scale, resulting in a preliminary scale composed of 70 items. In the main study, the preliminary scale was administered to a national representative sample of 562 middle-aged Korean adults. The scale was filtered into 40 items by the item analysis and an exploratory factor analysis, resulting in 6 factors: Family Connectedness & Problem Solving, Family's Positive Perception of Adversity, Family's Economic Stability, Family Religion & Spirituality, Support of Extended Family, and Support of Friends & Neighbors. These 6 factors explained 61.82% of total variance. The findings of the current study indicate substantial support for the reliability and the validity of the KMFRS. Other challenges and suggestions for future research on family resilience scale are discussed.

• 아동학회지
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• 제33권6호
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• pp.85-107
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• 2012

In this study, the Infants & Toddlers' Playfulness Scale(ITPS) was developed and its reliability and validity were examined. The participants in this study consisted of 656 parents whose children were 8 to 36 months old. Five factors were identified from the results of the exploratory factor analysis performed on the 29 items that had been derived by analyzing existing research. The Goodness of Fit Indices(GFIs) of the confirmatory factor analyses, performed on the 1st-order 5-factor model and the 2nd-order one factor model, were both satisfactory. Concurrent validity was established by the high correlations of r = .631~.808(p < .01) between each factor of the ITPS and the total score of the Children's Playfulness Scale(CPS), an existing measure for children's playfulness. The reliability of each factor, as measured by Cronbach's ${\alpha}$, ranged from .773 to .883. Consequently, the ITPS developed in this study can be seen as a reliable and valid scale that can be used by parents to measure the playfulness of their infants and toddlers in a multi-dimensional manner.

• BMB Reports
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• 제41권10호
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• pp.685-692
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• 2008

Colorectal cancer (CRC) is the third most common malignancy in the world. Because CRC develops slowly from removable precancerous lesions, detection of the disease at an early stage during regular health examinations can reduce both the incidence and mortality of the disease. Although sigmoidoscopy offers significant improvements in the detection rate of CRC, its diagnostic value is limited by its high costs and inconvenience. Therefore, there is a compelling need for the identification of noninvasive biomarkers that can enable earlier detection of CRC. Accordingly, many validation studies have been conducted to evaluate genetic, epigenetic or protein markers that can be detected in the stool or in serum. Currently, the fecal-occult blood test is the most widely used method of screening for CRC. However, advances in genomics and proteomics combined with developments in other relevant fields will lead to the discovery of novel non invasive biomarkers whose usefulness will be tested in larger validation studies. Here, non-invasive molecular biomarkers that are currently used in clinical settings and have the potential for use as CRC biomarkers are discussed.

• 아동학회지
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• 제15권1호
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• pp.5-21
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• 1994

The purpose of this study was to develop a scale for evaluation of early childhood programs in Korea. The procedures included content validation and a pilot test. A total of 192 items in 10 major areas was developed based on the review of literature and discussions with professionals in early childhood education. The 10 areas include: scheduling, curriculum, interation, physical environment, materials, nutrition, health and safety, administration, staff qualifications, relationships with parents, and evaluation. The pilot scale was administered to 428 classroom teachers and directors, and 47 college professors in early childhood education. The items were rated on a 3-point scale in terms of importance as evaluation criteria. The methods for data analysis included item means and standard deviations for content validation, Cronbach ${\alpha}$ for reliability, and factor analysis for construct validity. Most items in 10 areas were rated as moderate to highly important (average 2.3), especially items in curriculum and staff qualifications. Two factors emerged from the data: institutional management, and curricular planning and implementation. The Cronbach ${\alpha}$ levels were .70 or higher in most areas, but the range covers from .48 to .91. Based on the pilot data, 143 items were selected for the second year study.

• 아동학회지
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• 제27권4호
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• pp.219-232
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• 2006

The purpose of this research is to develop and validate an instrument that can be used to measure critical aspects of a parent's attitude and behavior that influence child development and adaptation. This instrument is named Parenting Style Inventory and self-reporting assessment of parent for preschoolers. We reported findings from 578 preschooler's care-givers. Five factors were extracted from 55 items developed for preschooler version and finally 29 items were selected. Subscales were empathy, respect, parental authority, coerciveness, perfectionism. Internal consistency of these subscales were .77, .86, .70, .74, .68 relatively. Empathy, respect and authoritative scales were regarded as the basic dimensions of parent's behavior. For clinical validation, we divided the preschooler care-giver sample into 8 groups according to scores of the basic dimensions and compared the 8 groups with parenting stress and parenting self-efficacy scores. The results indicated that three basic factors would have different effects on parental experiences and satisfaction. We suggested the clinical implication and limitation of this instrument.

• 약학회지
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• 제51권3호
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• pp.174-178
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• 2007

A reverse-phase high performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of doxifluridine and its active metabolite 5-flu-orouracil (5-FU) in monkey serum. The method has greater sensitivity and simpler process than previous published methods with good accuracy and precision. A proper liquid/liquid extraction was used to extract simultaneously doxifluridine and 5-FU which has considerable difference in the polarity. Extracts were analyzed using LC/MS/MS providing a short analysis time within 5 min. The lower limit of quantification was validated at 10.0 ng/ml of serum for both doxifluridine and 5-FU. Accuracy and precision of quality control (QC) samples for both analytes met FDA Guidance criteria of ±15% for average QC accuracy with coefficients of variation less than 15%. The method will be applicable for preclinical studies and bioequivalence studies.

• 아동학회지
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• 제36권5호
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• pp.95-113
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• 2015

This study aimed to develop and validate a scale which could be used to evaluate mathematical interactions of parents with their young children. The subjects comprised 408 mothers of 4-6-year-old children. Means, standard deviation, $x^2$, Cramer's V, exploratory factor analysis, confirmatory factor analysis, Pearson correlations, and Cronbach's ${\alpha}$ were calculated. First, 49 items were developed through a review of relevant research, parent interviews, confirmation of item adequacy and content validity. These items were then edited down to a final list of 24 items representing 4 factors identified by exploratory factor analysis. Second, this 24-item. 4-factor scale was shown to have adequate construct validity, norm validity, and reliability by confirmatory factor analysis, Pearson correlation analysis, Cronbach's ${\alpha}$. In conclusion, the final mathematical interaction scale for young children's parents was composed of 24 items with 4 factors: "interaction regarding numbers and operations, measurements, and patterns", "interaction regarding data collection and result presentation", "interaction with picture books", and "interaction regarding shapes and figures"