• Title/Summary/Keyword: vaccine effect

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A study on the antipyretic effect of Sibsin Tang in Rabbits (십신탕이 가토의 해열작용에 미치는 영향)

  • Lee, Soon-Ho;An, Nyeon Hyoung
    • Korean Journal of Clinical Pharmacy
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    • v.3 no.1
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    • pp.71-78
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    • 1993
  • The antipyretic effect of Sibsin-Tang in rabbits by injected typhoid vaccine was studied. The results are summarized as follows; 1. Maximum temperature was $39.76\pm0.28^{\circ}C$ after 60-240 minutes by injected typhoid vaccine. 2. Sibsin-Tang did not make normal temperature low but aminopyrine made normal temperature low in rabbits. 3. Increased temperature by typhoid vaccine was decreased by administration of Sibsin-Tang at 150 minutes. 4. Pretreated Sibsin-Tang did not affect on increased temperature by typhoid vaccine. 5. Propranolol did not affect on increased temperature by typhoid vaccine.

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Effect of Modified Live Virus Vaccine aganist Canine Parvovirus Infection (개 파보바이러스 감염에 대한 Modified Live Virus Vaccine의 효과)

  • 한정희;유기일;권혁무;서강문
    • Journal of Veterinary Clinics
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    • v.15 no.1
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    • pp.46-55
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    • 1998
  • This study was performed to verify the effect of modified live virus vaccine against canine parvovirus (CPV) infection. Serum hemagglutination inhibition (Hl) test, histopathological and immunohistochemical techniques and polymerase chain reaction were used. The results were as follows: 1. During the experimental terms after vaccination, serum Hl titer was stable. Geometric mean titer (GMT) after the 1st vaccination was 280. After virulent CPV was challenged, GMT was 1,306. 2. After challenge by virulent CPV, the vaccinated group was not shown clinical signs and gross and histopathological findings. 3. After challenge by virulent CPV, the vaccinated group was not detected viral antigens in the small intestine immunohistochemically. 4. After challenge by violent CPV, the vaccinated group was not shown virus shedding in feces. In conclusions the overall results confirmed that modified live virus vaccine was effective on prevention of canine parvovirus infection.

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Cancer Vaccines (암백신)

  • Son, Eun-Wha;In, Sang-Whan;Pyo, Suhk-Neung
    • IMMUNE NETWORK
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    • v.5 no.2
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    • pp.55-67
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    • 2005
  • Cancer vaccine is an active immunotherapy to stimulate the immune system to mount a response against the tumor specific antigen. Working as a stimulant to the body's own immune system, cancer vaccines help the body recognize and destroy targeted cancers and may help to shrink advanced tumors. Research is currently underway to develop therapeutic cancer vaccines. It is also possible to develop prophylactic vaccines in the future. The whole cell approach to eradicate cancer has used whole cancer cells to make vaccine. In an early stage of this approach, whole cell lysate or a mixture of immunoadjuvant and inactivated cancer cells has been used. Improved vaccines are being developed that utilize cytokines or costimulatory molecules to mount an attack against cancer cells. In case of melanoma, these vaccines are expected to have a therapeutic effect of vaccine. Furthermore, it is attempting to treat stomach cancer, colorectal cancer, pancreatic cancer, and prostate cancer. Other vaccines are being developing that are peptide vaccine, recombinant vaccine and dendritic cell vaccine. Out of them, reintroduction of antigen-specific dendritic cells into patient and DNA vaccine are mostly being conducted. Currently, research and development efforts are underway to develop therapeutic cancer vaccine such as DNA vaccine for the treatment of multiple forms of cancers.

Immune Response of the Japanese Eel(Anguilla japonica) to Vibrio anguillarum (Vibrio균에 대한 뱀장어 (Anguilla japonica)의 면역반응)

  • CHUN Seh-Kyu;KIM Jin-Woo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.18 no.5
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    • pp.464-470
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    • 1985
  • Some eels Anguilla japonica, ranging from 16 to 23 g in their weight(average: 20 g), were sampled at the private eel farming company equipped with water recycling system, located at Kimhae city, Kyungnam Province, Korea. Three kinds of vaccine were prepared with Vibrio anguillarum (EPM-8406) isolated at National Fisheries University in Korea for the immune response experiment against eels; those vaccines were made by inactivating the strain with $0.3\%$ formalin for 24 hrs at $25^{\circ}C$, heating for 3 mins or for 15 mins at $121^{\circ}C$, respectively. The various optimal vaccination conditions for the control of vibriosis in the fish were investigated based on the cultivation temperature, vaccination concentration and booster effect. The maximum titer rapidly increased with higher temperature up to $23^{\circ}C$, but there were little differences between $23^{\circ}C\;and\;28^{\circ}C$. The formalin-killed vaccine showed good efficacy at the injection concentration of above $10^8$ cells per fish and little effect at the below $10^7$ cells. The booster effect on the vaccination showed good efficacy above twice-injections with little difference between the numbers of injection.

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Protective effects and immunogenicity of Salmonella Enteritidis killed vaccine strains selected from virulent Salmonella Enteritidis isolates (Salmonella Enteritidis 분리주에서의 선발된 불활화 백신균주의 방어효과 및 면역원성)

  • Kang, Zheng-Wu;Won, Ho-Keun;Kim, Eun-Hee;Noh, Yun-Hee;Choi, Hwan-Won;Hahn, Tae-Wook
    • Korean Journal of Veterinary Research
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    • v.51 no.1
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    • pp.21-28
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    • 2011
  • Salmonella Enteritidis (SE) has been a major causative agent of food-borne human disease due to consumption of contaminated eggs and poultry meat. To prevent SE infection in poultry, and therefore minimize human infections, vaccination with either killed or live SE vaccine is suggested. We evaluated a newly developed killed bacterin using a representative SE isolate in Korea. Among pool of SE isolates, two highly virulent isolates (the one isolate from chicken, the other from human) were selected by measuring mortality in mouse and chickens administered. The chickens were injected intramuscularly with killed vaccine and were challenged with highly virulent SE strain 3 week after vaccination. The recovered colony count (cfu/g) of spleen and cecal content in the vaccinated groups was reduced compared with those of the unvaccinated control group. The antibody level in the vaccinated groups was higher at 3 week post vaccination. These results indicate that vaccination with killed vaccine was effective in preventing the infection of virulent SE. Further study for a large number of layers should be needed for the effect of egg production, SE shedding in feces, persistence of antibody level.

A case of alopecia areata after rabies vaccination: unreported adverse effect?

  • Guiying Qiu;Xinrong Chen
    • Clinical and Experimental Vaccine Research
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    • v.13 no.2
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    • pp.171-173
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    • 2024
  • Alopecia areata (AA) is an autoimmune-related disorder characterized by non-scarring hair loss in children. We report the case of a child who had AA after the fifth dose of rabies vaccine and summarized various potential mechanisms of vaccination induced AA. This case indicates that rabies vaccine might be a predisposition of AA by causing immune dysregulation.

COVID-19 Vaccination for Pilots and Air Traffic Controllers (항공종사자와 코로나바이러스감염증-19 백신 예방 접종)

  • Kwon, Young Hwan
    • Korean journal of aerospace and environmental medicine
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    • v.31 no.1
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    • pp.13-16
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    • 2021
  • The coronavirus disease-19 (COVID-19) vaccine is expected to play an important role in stopping the pandemic. Studies show that COVID-19 vaccines are effective at keeping you from getting COVID-19. Getting a COVID-19 vaccine will also help keep you from getting seriously ill even if you do get COVID-19. Efforts to find an effective vaccine against severe acute respiratory syndrome coronavirus 2 have progressed unprecedentedly through active support from public research grants and private-public partnership programs. Clinical studies have been actively conducted, and some vaccines are being vaccinated with approval for urgent use. The WHO has approved and supplied the Pfizer-BioNTech COVID-19 vaccine and the Oxford-AstraZeneca COVID-19 vaccine. In Korea, the Oxford-AstraZeneca vaccine was approved for urgent use, and vaccination began on February 26, 2021. In this paper, the efficacy and side effects of each vaccines and the effect on pilots and air traffic controllers related to COVID-19 vaccination were investigated in terms of aviation medicine.

Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro

  • Dai, Wenwen;Wu, Yu;Bi, Jinpeng;Wang, Jingyu;Wang, Shuai;Kong, Wei;Barbier, Julien;Cintrat, Jean-Christophe;Gao, Feng;Jiang, Zhengran;Gillet, Daniel;Su, Weiheng;Jiang, Chunlai
    • Journal of Microbiology and Biotechnology
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    • v.28 no.6
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    • pp.849-859
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    • 2018
  • Herpes simplex virus type 2 (HSV-2) infection has been a public health concern worldwide. It is the leading cause of genital herpes and a contributing factor to cervical cancer and human immunodeficiency virus (HIV) infection. No vaccine is available yet for the treatment of HSV-2 infection, and routinely used synthetic nucleoside analogs have led to the emergence of drug resistance. The small molecule $Retro-2^{cycl}$ has been reported to be active against several pathogens by acting on intracellular vesicle transport, which also participates in the HSV-2 lifecycle. Here, we showed that Retro-2.1, which is an optimized, more potent derivative of $Retro-2^{cycl}$, could inhibit HSV-2 infection, with 50% inhibitory concentrations of $5.58{\mu}M$ and $6.35{\mu}M$ in cytopathic effect inhibition and plaque reduction assays, respectively. The cytotoxicity of Retro-2.1 was relatively low, with a 50% cytotoxicity concentration of $116.5{\mu}M$. We also preliminarily identified that Retro-2.1 exerted the antiviral effect against HSV-2 by a dual mechanism of action on virus entry and late stages of infection. Therefore, our study for the first time demonstrated Retro-2.1 as an effective antiviral agent against HSV-2 in vitro with targets distinct from those of nucleoside analogs.

Protective Effect of CFC-101, a Pseudomonas Vaccine, in Mice (마우스에서 CFC-101 (녹농균 백신)의 감염 방어효과)

  • 김영지;김제학;박완제;안동호;홍광희;김현수;김유삼;함경수
    • Biomolecules & Therapeutics
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    • v.2 no.4
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    • pp.322-325
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    • 1994
  • To optimize the immunological efficacy of CFC-101, an outer-membrane protein vaccine purified from relatively less pathogenic 4 different Pseudomonas aeruginosa strains, we investigated to establish its dose, administration route, interval and frequency of vaccination in mice. As expected, the 4 CFC-101 producing strains were less pathogenic than the challenging organism, P. aeruginosa GN11189. CFC-101 completely protected the death caused by P. aeruginosa at above 0.05 mg/kg vaccinized by 3 times with 7-day intervals. At the optimally effective dose of 0.2 mg/kg of CFC-101, at least 3 immunizations were necessary for complete protection against P. aeruginosa-induced death. If immunized 3 times, the immunization interval could be shortened up to 2 days to acquire the best protection against P. aeruginosa. CFC-101 was effective either by intraperitoneal, subcutaneous or intramuscular but not by oral administration. The present results show that the newly developed Pseudomonas vaccine, CFC-101, is highly effective for the protection from death caused by pseudomonal infections.

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Immunoprophylactic effect of synthetic polypeptide vaccine derived from Theileria sergenti merozoite (Theileria sergenti merozoite부터 합성한 polypeptide vaccine의 예방효과 연구)

  • Baek, Byeong-kirl;Jung, Jae-myeong;Kim, Byung-soo
    • Korean Journal of Veterinary Research
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    • v.36 no.2
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    • pp.453-461
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    • 1996
  • Eighteen holstein-calves(4~5 months old) in a divided groups including the matched control were immunized with $100{\mu}g/dose$ of 34kDa, 45kDa polypeptide and T sergenti merozoite vaccine(protein content $100{\mu}g/dose$) respectively, previously mixed with aluminium hydroxide to elicit antibodies. All groups of calves were boosted with same dose and intervals. The animals were challenged by tick infestations in the endemic pasture of theileriosis from March to September 1994. The animals were monitored for the erythrocyte count, parasitemia, hematocrit and the specific antibody reactions elicited by immunization. The immunological responses demonstrated that vaccination with 34kDa polypeptide and T sergenti merozoite derived vaccine inhibited to produce the 75kDa band immunological responds even in the vaccinated calves after being challenged by tick infestations in the pasture. However, the specific antibody reactions were detected at the 32kDa band in the nonimmunized calves and T sergenti merozoite derived vaccine by the western blot. The 34kDa polypeptide vaccine and T sergenti merozoite derived vaccine were evaluated to be able to protect inducing anemia and to decrease parasitemias level. These vaccines have the efficacy of inhibition to produce a certain antigen corresponding 75kDa band antigen of parasite in the calves as challenged with tick infestations.

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