• 대한수학회보
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• 제57권4호
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• pp.1003-1031
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• 2020

We consider the following Dirichlet initial boundary value problem with a gradient absorption and a nonlocal source $$\frac{{\partial}u}{{\partial}t}-div({\mid}{\nabla}u{\mid}^{p-2}{\nabla}u)={\lambda}u^k{\displaystyle\smashmargin{2}{\int\nolimits_{\Omega}}}u^sdx-{\mu}u^l{\mid}{\nabla}u{\mid}^q$$ in a bounded domain Ω ⊂ ℝ^N, where p > 1, the parameters k, s, l, q, λ > 0 and µ ≥ 0. Firstly, we establish local existence for weak solutions; the aim of this part is to prove a crucial priori estimate on |∇u|. Then, we give appropriate conditions in order to have existence and uniqueness or nonexistence of a global solution in time. Finally, depending on the choices of the initial data, ranges of the coefficients and exponents and measure of the domain, we show that the non-negative global weak solution, when it exists, must extinct after a finite time.

• Composites Research
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• 제15권1호
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• pp.1-8
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• 2002

본 연구에서는 실제 구조형상의 사각형 상자형 날개와 전투기 날개에 대하여 구조재를 표피(skin)부분은 복합재료로 대체하고, 나머지 스파(spar)와 리브(rib)는 알루미늄으로 하여 플러터 해석을 수행하였다. MS/PATRAN을 이용하여 실제 날개 구조에 근사한 3차인 유한 요소 모델이 구축되었고, MSC/NASTRAN을 이용하여 고유진동 해석이 수행되었다. 유한 요소는 멤브레인(membrane)요소, 1차원 막대(rod)요소, 전단패널(shear panel)요소를 사용하였다. 복합재료의 적층은 실제적인 적층각을 이용하여 다양하게 변화시켜 해석하였다. 아음속 영역에서 비정상 공력 해석을 위하여 주파수 영역에서의 선형 공기력 이론인 DLM코드가 적용되었고, 주파수 영역 공탄성 지배방정식의 해법으로 V-g방법 및 p-k방법이 적응되었다.

• 지질공학
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• 제13권4호
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• pp.419-428
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• 2003

지반을 대상으로 지하수의 이동 및 오염물질 침투에 대한 평가를 위해, 지반을 구성하고 있는 매질의 공극률과 유효공극률을 파악하는 것은 매우 중요하다. 이들은 물질 이동을 결정하는 중요한 물리적 파라메터이다. 본 연구에서는 새로운 유전율 시스템인 FOR-V (Frequency domain reflectometry with vector network analyzer)를 적용하여 표준사 (Standard sand)와 강모래 (River sand)에 대한 공극률 및 유효공극률을 측정하기 위한 실험적 연구를 실시하였다. 또한, 이들을 측정하기 위해, 다공질 매질에 대한 유전율상수의 특성을 고려한 유전율 믹싱모델 (dielectric FDR-V 시스템을 적용한 주입실험 (Injection test)과 주입물질의 농도를 측정하는 치환실험 (Replacement test)을 수행하였다. 두 종류의 실험 결과치를 비교한 결과, 측정된 유효공극률을 공극률과 비교해 보면, 약 85 - 92 %의 범위 내에 존재하는 것으로 측정되었다. 일반적인 흙의 유효공극률은 공극률에 대해 약 90 % 범위 내에 분포하고 있는 것으로 알려져 있으나, 본 연구에서는 다소 낮은 결과치를 보이고 있다. 이러한 현상은 시스템의 측정 프로브의 측정 범위가 직경 0.36 cm의 동축측정프로브 끝부분에서 이루어져 비교적 작기 때문에 제작된 흙 시료전 체적에 대한 유효공극률의 결과치이기 보다는 프로브가 위치한 지점에 대한 측정치로 판단된다. 이러한 측정 프로브의 특성을 고려해 볼 때, FDR-V 시스템은 연구자가 의도한 연구에 따라 특정 지점에 대한 지반의 정밀한 물리적 특성을 파악할 수 있을 것으로 사료된다.

• Genomics & Informatics
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• 제19권4호
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• pp.48.1-48.10
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• 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes small envelope protein (E) that plays a major role in viral assembly, release, pathogenesis, and host inflammation. Previous studies demonstrated that pyrazine ring containing amiloride analogs inhibit this protein in different types of coronavirus including SARS-CoV-1 small envelope protein E (SARS-CoV-1 E). SARS-CoV-1 E has 93.42% sequence identity with SARS-CoV-2 E and shared a conserved domain NS3/small envelope protein (NS3_envE). Amiloride analog hexamethylene amiloride (HMA) can inhibit SARS-CoV-1 E. Therefore, we performed molecular docking and dynamics simulations to explore whether amiloride analogs are effective in inhibiting SARS-CoV-2 E. To do so, SARS-CoV-1 E and SARS-CoV-2 E proteins were taken as receptors while HMA and 3-amino-5-(azepan-1-yl)-N-(diaminomethylidene)-6-pyrimidin-5-ylpyrazine-2-carboxamide (3A5NP2C) were selected as ligands. Molecular docking simulation showed higher binding affinity scores of HMA and 3A5NP2C for SARS-CoV-2 E than SARS-CoV-1 E. Moreover, HMA and 3A5NP2C engaged more amino acids in SARS-CoV-2 E. Molecular dynamics simulation for 1 ㎲ (1,000 ns) revealed that these ligands could alter the native structure of the proteins and their flexibility. Our study suggests that suitable amiloride analogs might yield a prospective drug against coronavirus disease 2019.

• 대한수학회지
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• 제59권3호
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• pp.571-594
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• 2022

Let D be an integral domain with quotient field K, Pic(D) be the ideal class group of D, and X be an indeterminate. A polynomial overring of D means a subring of K[X] containing D[X]. In this paper, we study almost Dedekind domains which are polynomial overrings of a principal ideal domain D, defined by the intersection of K[X] and rank-one discrete valuation rings with quotient field K(X), and their ideal class groups. Next, let ℤ be the ring of integers, ℚ be the field of rational numbers, and 𝔊f be the set of finitely generated abelian groups (up to isomorphism). As an application, among other things, we show that there exists an overring R of ℤ[X] such that (i) R is a Bezout domain, (ii) R∩ℚ[X] is an almost Dedekind domain, (iii) Pic(R∩ℚ[X]) = $\oplus_{G{\in}G_{f}}$ G, (iv) for each G ∈ 𝔊f, there is a multiplicative subset S of ℤ such that RS ∩ ℚ[X] is a Dedekind domain with Pic(RS ∩ ℚ[X]) = G, and (v) every invertible integral ideal I of R ∩ ℚ[X] can be written uniquely as I = XnQe11···Qekk for some integer n ≥ 0, maximal ideals Qi of R∩ℚ[X], and integers ei ≠ 0. We also completely characterize the almost Dedekind polynomial overrings of ℤ containing Int(ℤ).

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 춘계학술대회
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• pp.88-90
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• 2012

본 논문은 rail-to-rail 입력 범위를 가지는 10-bit 10-MS/s 비동기 축차근사형 (SAR: successive approximation register) 아날로그-디지털 변환기 (ADC: analog-to-digital converter)를 제안한다. 제안된 SAR ADC는 커패시터 디지털-아날로그 변환기 (DAC: digital-to-analog converter), SAR 로직, 그리고 비교기로 구성된다. 외부에서 공급되는 클럭의 주파수를 낮추기 위해 SAR 로직과 비교기에 의해 비동기로 생성된 내부 클럭을 사용한다. 또한 높은 해상도를 구현하기 위해 오프셋 보정기법이 적용된 시간-도메인 비교기를 사용한다. 면적과 전력소모를 줄이기 위해 분할 캐패시터 기반 차동DAC를 사용한다. 설계된 비동기 SAR ADC는 0.18-um CMOS 공정에서 제작되며, core 면적은 $420{\times}140{\mu}m^2$이다. 1.8 V의 공급전압에서 0.818 mW의 전력 소모와 91.8 fJ/conversion-step의 FoM을 가진다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권2호
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• pp.173-177
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• 2006

In this study, a novel strategy was developed for the highly selective immobilization of proteins, using the polyhydroxyalkanoate (PHA) depolymerase substrate binding domain (SBD) as an active binding domain. In order to determine the appropriacy of this method for immunodiagnostic assays, the single-chain antibody (ScFv) against the hepatitis B virus (HBV) preS2 surface protein and the severe acute respiratory syndrome coronavirus (SARS-CoV) envelope protein (SCVe) were fused to the SBD, then directly immobilized on PH A-coated slides via microspotting. The fluorescence-labeled HBV antigen and the antibody against SCVe were then utilized to examine specific interactions on the PHA-coated surfaces. Fluorescence signals were detected only at the spotted positions, thereby indicating a high degree of affinity and selectivity for their corresponding antigens/antibodies. Furthermore, we detected small amounts of ScFv-SBD (2.7 ng/mL) and SCVe-SBD fusion proteins (0.6ng/mL). Therefore, this microarray platform technology, using PHA and SBD, appears generally appropriate for immunodiagnosis, with no special requirements with regard to synthetic or chemical modification of the biomolecules or the solid surface.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권3호
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• pp.114-119
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• 2005

We investigated compatibilizing effects of electrical properties such as charge distributions and electrical breakdown in blends of low density polyethylene (LDPE) / polystyrene (PS) with poly [styrene-b-(ethylene-co-butylene)-b-styrene] (SEBS), the triblock copolymer. The blends with $70\;wt\%$ of LDPE and $30\;wt\%$ of PS were prepared through a melt blending in a batch type kneader at a temperature of $220^{\circ}C$ when the SEBS content increased up to $10\;wt\%$. Scanning electron microscopy (SEM) was investigated for observation of morphology of LDPE / PS blends increasing SEBS contents. The morphological observation showed that addition of SEBS results in the domain size reduction of the dispersed PS phase and a better interfacial adhesion between LDPE and PS phases. Measurements of space charge distributions for blends was carried out with pulsed electroacoustic (PEA) method. It was possible to observe that the amount of charge storage in the LDPE / PS blends decreased wiか increasing of SEBS content. The location of SEBS at a domain interface enables charges to move from one phase to the other via domain interface and results in a indicative decrease in the amount of space charge for the LDPE / PS blends with SEBS. Electrical breakdown strength of these blends was observed. It was found that the maximum breakdown strength of the blend was 51.55 kV/mm. These results were better than 38.38 kV/mm of LDPE used electrical insulator for cables and were caused by crystalinity of blends. Because the crystalinity of blends were lower than LDPE, electrical breakdown strength of LDPE / PS blends is higher than that of LDPE. We evaluated the possibility of these blends for insulating material substituted LDPE.

• 한국전자파학회논문지
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• 제10권7호
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• pp.1065-1073
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• 1999

본 논문에서는 Haar 웨이블릿 기반 MRTD(MultiRes빼lion Time-Domain)를 이용하여 다층 PCB (Printed C Circuit Board)의 전원 공급면내에서 발생할 수 있는 Ground Bounce 문제를 해석하였다. 기존의 FDTD법을 이용한 모델링에서는 PCB 전원 공급연을 구성하는 $V_{cc}$연과 접지면 사이의 좁은 간격을 표현하기 위해 수직 방향으로 매우 작은 셀이 필요하다. 이에 따라 안정 조건(Stability Con며tion)에 의한 시간간격 $\Deltat$가 매우 작아 일정 시간 동안의 응답을 관찰하기 위해 많은 수의 반복 계산(Iteration)을 수행해야 한다. 이러한 문제 에 대해 MRTD를 적용하여 수직 방향 셀 크기를 두 배로 증가시켜 해석함으로써 계산 시간을 현저하게 감 소시킬 수 있다. 또한 MRTD에 의한 결과는 FDTD법에 의한 결과 및 해석적인 해와 매우 잘 일치한다. 본 논문의 결과는 PCB 상의 EMI/EMC 문제의 해석에 있어 MRTD의 정확성과 효율성을 잘 나타낸다.

• The Korean Journal of Physiology and Pharmacology
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• 제20권5호
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• pp.525-531
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• 2016

The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying $K^+$ current. In this study, we examined whether a ${\mu}$-opioid agonist, [D-Ala2,N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), affects the two-pore domain $K^+$ channel (K2P) current in rat SG neurons using a slice whole-cell patch clamp technique. Also we confirmed which subtypes of K2P channels were associated with DAMGO-induced currents, measuring the expression of K2P channel in whole spinal cord and SG region. DAMGO caused a robust hyperpolarization and outward current in the SG neurons, which developed almost instantaneously and did not show any time-dependent inactivation. Half of the SG neurons exhibited a linear I~V relationship of the DAMGO-induced current, whereas rest of the neurons displayed inward rectification. In SG neurons with a linear I~V relationship of DAMGO-induced current, the reversal potential was close to the $K^+$ equilibrium potentials. The mRNA expression of TWIK (tandem of pore domains in a weak inwardly rectifying $K^+$ channel) related acid-sensitive $K^+$ channel (TASK) 1 and 3 was found in the SG region and a low pH (6.4) significantly blocked the DAMGO-induced $K^+$ current. Taken together, the DAMGO-induced hyperpolarization at resting membrane potential and subsequent decrease in excitability of SG neurons can be carried by the two-pore domain $K^+$ channel (TASK1 and 3) in addition to inwardly rectifying $K^+$ channel.